jaamzg wrote:If Chromium were to help move the AA into the cells from the plasma, I would assume that the plasma levels would drop and allow for greater bowel tolerance levels in a healthy individual.
This is not right. More C in cells means more C in plasma because cells release C back into the plasma.
I must admit that chromium + C is excelent idea. I researched it some more using the query on Google schoolar given bellow:
Code: Select all
intitle:chromium intitle:"ascorbic acid" | intitle:"vitamin c"
There are not that many studies, only 1 in humans with diabetes testing Cr + C + E. Others are in chickens, cows, guinea pigs, rats, etc. There are studies looking into effects on other nutrients, on tissue saturation of Cr and AA and urinary excretion. The only potential negative effect is reduction in Cu absorption (again, known side effect of AA which might be problematic for some people in the context of Cu deficient diet for longer time).
My quick scan showed that they all show positive effects and additive effect of combination. This is reasonable: Cr brings blood glucose down (good for C) although it also brings insulin down (which is not good for C absorption) however this is due to increased insulin sensitivity so that lower amounts of insulin can bring the same effects as higher amounts before Cr supplementation , so all in all, this looks like good for C bioavailability.
It also looks like AA promotes Cr absorption. Also, toxicity of Cr-6 is known in dermatology and AA is used to reduce it to Cr-3 and prevent toxicity. This might be important in some scenarios.
They seem to have aditional additive effects, for instance reduction of cholesterol or even improvement in osteoporosis.
References:
apellmann, M., and Bolt, H. (1992). Chromium (VI) reducing capacity of ascorbic acid and of human plasma in vitro. Archives of Toxicology
66, 45–50.
Chatterjee, G.C., Roy, R.K., Sasmal, N., Banerjee, S.K., and Majumder, P.K. (1973). Effect of chromium and tungsten on L-ascorbic acid metabolism in rats and chicks. J. Nutr.
103, 509–514.
Lai, M.-H. (2008). Antioxidant effects and insulin resistance improvement of chromium combined with vitamin C and e supplementation for type 2 diabetes mellitus. J Clin Biochem Nutr
43, 191–198.
Lee1a, H.G., Yina, J.L., Xu, C.X., Hong, Z.S., Lee, Z.H., Jin, Y.C., Choi, C.W., Lee, D.H., Kim, K.H., and Choi, Y.J. (2011). Effects of the Combination of Glucose, Chromium Picolinate, and Vitamin C on Lipid Metabolism in Steers.
Sahin, K., Onderci, M., Sahin, N., and Aydin, S. (2002a). Effects of dietary chromium picolinate and ascorbic acid supplementation on egg production, egg quality and some serum metabolites of laying hens reared under a low ambient temperature (6 degrees C). Arch Tierernahr
56, 41–49.
Sahin, K., Sahin, N., and Kucuk, O. (2002b). Effects of dietary chromium and ascorbic acid supplementation on digestion of nutrients, serum antioxidant status, and mineral concentrations in laying hens reared at a low ambient temperature. Biological Trace Element Research
87, 113–124.
Sahin, K., Sahin, N., and Kucuk, O. (2003). Effects of chromium, and ascorbic acid supplementation on growth, carcass traits, serum metabolites, and antioxidant status of broiler chickens reared at a high ambient temperature (32°C). Nutrition Research
23, 225–238.
Seaborn, C.D. (1990). Chromium-nutrient interactions affecting tissue chromium, vitamin C metabolism, and cholesterol synthesis.
Seaborn, C.D., Cheng, N., Adeleye, B., Owens, F., and Stoecker, B.J. (1994). Chromium and chronic ascorbic acid depletion effects on tissue ascorbate, manganese, and 14C retention from 14C-ascorbate in guinea pigs. Biol Trace Elem Res
41, 279–294.
Seaborn, C.D., and Stoecker, B.J. (1990). Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium. Nutrition Research
10, 1401–1407.