Moderator: ofonorow
Johnwen wrote:Dolev etc.
Something that Big Pharma Hides and Doc's don't get taught.
INSULIN
Controls Cholesterol!!!
Low Insulin = low cholesterol
Cells eat 2 things Fat and sugar! If they got enough sugar they reject it along with insulin back to the liver it goes! Liver says, Oh they must have enough sugar lets give them the other course of their meal FAT! (cholesterol=Fat wrapped in a package because fat don't do so good in watery substances)
I have a flow chart if you wish I can post it.
sean wrote:hi everyone,
Will 1000mg of daily Vitamin B3 ( Niacin) cause a raise in blood sugar and causes type 2 diabetic?
REMEMBER the secret to niacin is to take it away from food and to fast for 5-6 hours after because it makes your serum FFA spike which in turns make you severely glucose intolerant and insulin resistant.
Dolev wrote:How does one raise cholesterol level? I just received the blood tests of a problematic young man with a total cholesterol of 103.
I dont understand this because of my dad
he has high insulin and total cholesterol 114 (mg/dL)
HDL 26 (mg/dL)
LDL 74 (mg/dL
triglycerides 69 (20-150)mg/dL)
vitD 57ng/ml (30-100)
HS-CRP .2 mg/L
A1C---7 4-6
fasting glucose 144
total T 293ng/dl (240-950)
E2: 44(18-40)
He is seeing a MD to get his T/E ratio better, his E2 down, but his blood sugar is out of control yet he has good cholesterol?
johnyascorbate wrote:What is the best form of Niacin one should be taking for good overall health?
Johnwen wrote:I dont understand this because of my dad
he has high insulin and total cholesterol 114 (mg/dL)
HDL 26 (mg/dL)
LDL 74 (mg/dL
triglycerides 69 (20-150)mg/dL)
vitD 57ng/ml (30-100)
HS-CRP .2 mg/L
A1C---7 4-6
fasting glucose 144
total T 293ng/dl (240-950)
E2: 44(18-40)
He is seeing a MD to get his T/E ratio better, his E2 down, but his blood sugar is out of control yet he has good cholesterol?
BLADE:
Two things that are in need of correction Here!!!
1.) Fasting Glucose is NOT INSULIN!!!!!! Normal Glucose Levels are 80 to 99 Mg/dL Since His fasting glucose level is 144Mg/dL It is quite appearent he is INSULIN DEFFICENT!! Be it low production (Type 1) or Ineffective Insulin (type 2)
Here’s what a insulin test is and what is normal!
http://labtestsonline.org/understanding ... n/tab/test
2.) His total cholesterol is NOT GOOD! In fact it’s in the down right Dangerous levels. Anything below 150 Mg/dL the body goes into survival mode and the first things to shut down are Hormone production. Which in your dad’s case is very apparent by his low T levels which are allowing his E2 (estrogen) levels to increase. His cortisol levels are probably bottomed out also!
What you have presented here just proves the point if not enough insulin is present the cholesterol production will be (is) low!
Without knowing you or your dad I’m going to take a shot here about what your Dad is experiencing as far as symptoms.
I estimate his age is in the late 50’s to early 60’s.
He’s probably experiencing fatigue and excessive tiredness. His joints hurt and present with arthritis type symptoms. He has a hard time concentrating on one subject Like reading. When you talk to him at times he hears you but ask’s you to repeat things. Rather short tempered lately. He probably had some cardiac problems like arrhythmias high blood pressure and some sort of urinary problems. It probably seems like every time you see him he got a cold or is coughing up globs! Then there’s that mid section bulge better known as a DUNLAP because it done laps over his belt!
Generally he don’t seem like the guy that raised you!
If this hit’s home on a few of these he’s seeing the results of low cholesterol and the lack of hormones that follows.
If he is diabetic he needs to talk to his doc about upping his dosage of insulin which will not only lower his sugar levels but allow his body to start getting his cholesterol up into a safe range. If he’s taking a statin drug he needs to get off it asap! Then cut the sugar and carb’s till his insulin is back on track!
Then there’s those that will bring up the issue of supplementing with the “Death Hormone!” Cortisol! But in reality it only masks the true problem and presents other problems.
http://www.selfgrowth.com/articles/cort ... th-hormone
Johnwen wrote:Blade;
The Leydig cells use What to make androgens including testosterone??
If the body is low on this substance the Leydig cells can stimulate production at a low level of what??
To maintain their production at a reduced level!
Johnwen wrote:Blade;
I’d take a good hard look at the pancreas first starting with some simple blood tests.
Blood Test’s;
Amylase
Lipase
Serum Glucagon
Serum Insulin
A1c (actual not calculated)
Chem 12 (CMP)
Stool Test;
Fecal elastase-1
First A1c is the average of glucose levels High means he’s been experiencing high glucose levels for a period of more then 2 month’s!
So as far as the a1c being high is a sign, it just shows he’s not producing or using insulin properly and with the resulting LOW Cholesterol he’s not going to be able to produce enough T. Like a factory that doesn’t have enough raw materials it’ll only produce what it can, with what it got to work with!
T is a product that needs cholesterol to be produced!
Sometimes doc’s over look the basic’s and only threat the symptoms in your dad’s case he COULD have something like a gall stone that’s gumming up the works yet it’s not showing any symptoms so that’s not what the doc’s are looking at or for. Today’s doc’s seem to forget that the body works as a system and what’s causing one problem maybe something that’s messed up that’s not showing any indications of being the main problem. Then there’s the “Treat em and Street Em!” attitude that I won’t get into!
blade wrote:Why dont you think his high a1c is caused by his low testosterone?
He's in his late 60s, Testosterone starts falling after you turn 30 or so
blade wrote:Saying step one is shoot him with some test. cyp, but to lower his high e2, see if things resolve then do HRT
exitium wrote:blade wrote:Saying step one is shoot him with some test. cyp, but to lower his high e2, see if things resolve then do HRT
Since E levels are used as one of the feedback mechanisms to test production lowering E likely will have a positive effect on test levels but I think your going about this all wrong. You seem to be hell bent on finding a smoking gun BUT I would wager the problem is more broad in nature.
high E and low T can be caused and affected by many things but what they all have in common is nutrition or lack thereof. Whether by exposure to toxins, parasites, virus's, poor food sources or what have you, deprive the body of the basic underlying building blocks for optimal organism function and things begin to break down.
I commented on another thread you posted in about this and my recommendation would be to go after the pauling therapy but dont stop there, identify and add in all the other nutrients as well. Many of the B vits are critical for proper sexual hormone production along with zinc and magnesium. There is plenty of science also linking thyroid function to sex hormone levels. Give your fathers body the nutrients needed to support thryoid function like lugols iodine and selenium.
Potassium is also hugely missing from most peoples diet and the list goes on. Proper supplements in the proper form are key. b12 should be taken transdermally or sublingually and should ideally be methylcobalamin (source naturals is only brand I have found to work so far). Use methyl folate and not folic acid.
Indications for testosterone therapy should be no different to men without diabetes and be reserved for clinical androgen deficiency with sustained, unequivocally low testosterone after appropriate diagnostic workup. Testosterone therapy should not be routinely given to men with diabetes and low-normal testosterone until benefit is confirmed by well-conducted clinical trials.
Disclosure: the author is an employee of Bayer-Schering Pharma, the manufacturer of testosterone products.
Clinical Interventions in Aging 2012:7The limitations to our study are characteristic of patient registries where, unlike placebo-controlled studies, physician and patient behavior are not directed. There was a high degree of variability in inter-patient data collection, no standardized definition of TD, no testosterone washout period before enrollment, no centralized laboratory testing facility, and no standardized time of testosterone draw. The differences between the primary age groups in enrollment sample size, although expected given that the study is not a controlled trial, may have influenced statistical analyses. Also, patient-supplied records were the evidence used for drug compliance.
Johnwen wrote:I agree with ExT. that you seem hell bent on this so I can just wish you the best of luck to your dad. However with more then 40 years of clinical experience under my belt. It would not be the route I would pursue to correct his problems and I doubt any other physician would write a script for t-replacement without more in depth testing and correction of existing problems before instituting this therapy.
Johnwen wrote:But there is the one’s who would use the, “try and see approach,” However to me the risks far out weight any benefit he would gain from this
Johnwen wrote:As far as your claim about the links you provided, below you might be interested in what was written in, an linked too within them! It’s not all good as you proclaim them to be!
Johnwen wrote:If you do succeed in finding a doc who’s willing to take a shot in the dark my hopes are that your dad is among those who experience a benefit from it. Just remember with any hormone replacement therapy that the ugly side that don’t show it’s head right away and may come on with a vengeance a few month’s down the road. So constant periodical monitoring is essential
Johnwen wrote:From the first link you provided in the related articles!
http://www.everydayhealth.com/health-re ... erone.aspx
Johnwen wrote:From the full text article in the link you provided
http://www.ncbi.nlm.nih.gov/pubmed/21646372Indications for testosterone therapy should be no different to men without diabetes and be reserved for clinical androgen deficiency with sustained, unequivocally low testosterone after appropriate diagnostic workup. Testosterone therapy should not be routinely given to men with diabetes and low-normal testosterone until benefit is confirmed by well-conducted clinical trials.
In this study of 30 men around 30 years old! The thing I find interesting is where it comes from!
http://www.ncbi.nlm.nih.gov/pubmed/20126841Disclosure: the author is an employee of Bayer-Schering Pharma, the manufacturer of testosterone products.
Then from the last link here; From full test version
http://www.ncbi.nlm.nih.gov/pubmed/19020265
These authors also are employed by drug companies! Remember there’s a lot of lawsuits filed for older men who had complications from TRT!(pop quiz, why do OLD guys on TRT have issues?)_
So they have to throw up a lot of defensesClinical Interventions in Aging 2012:7The limitations to our study are characteristic of patient registries where, unlike placebo-controlled studies, physician and patient behavior are not directed. There was a high degree of variability in inter-patient data collection, no standardized definition of TD, no testosterone washout period before enrollment, no centralized laboratory testing facility, and no standardized time of testosterone draw. The differences between the primary age groups in enrollment sample size, although expected given that the study is not a controlled trial, may have influenced statistical analyses. Also, patient-supplied records were the evidence used for drug compliance.
All these sound great in abstract till you get into the meat of the study then you start finding the pitfalls!
You keep claiming that raising T is a cure! It’s not!!wrong,but you have to do it right Low t is a symptom of something else going wrong in the system that supplies it’s production!(yeah like getting old and/or fat)
Plain and simple however it appears your stuck on it being a cure all! It’s my hope if you get a script for it. I just hope your dad don’t have to pay the price!
Johnwen wrote:But there is the one’s who would use the, “try and see approach,” However to me the risks far out weight any benefit he would gain from this
Johnwen wrote:As far as your claim about the links you provided, below you might be interested in what was written in, an linked too within them! It’s not all good as you proclaim them to be!
Johnwen wrote:If you do succeed in finding a doc who’s willing to take a shot in the dark my hopes are that your dad is among those who experience a benefit from it. Just remember with any hormone replacement therapy that the ugly side that don’t show it’s head right away and may come on with a vengeance a few month’s down the road. So constant periodical monitoring is essential
Johnwen wrote:From the first link you provided in the related articles!
http://www.everydayhealth.com/health-re ... erone.aspx
Johnwen wrote:From the full text article in the link you provided!
http://www.ncbi.nlm.nih.gov/pubmed/21646372
In this study of 30 men around 30 years old! The thing I find interesting is where it comes from!
http://www.ncbi.nlm.nih.gov/pubmed/20126841Disclosure: the author is an employee of Bayer-Schering Pharma, the manufacturer of testosterone products.
65
These authors also are employed by drug companies! Remember there’s a lot of lawsuits filed for older men who had complications from TRT!(pop quiz, why do OLD guys on TRT have issues?)_
So they have to throw up a lot of defenses
All these sound great in abstract till you get into the meat of the study then you start finding the pitfalls!
You keep claiming that raising T is a cure! It’s not!!wrong,but you have to do it right Low t is a symptom of something else going wrong in the system that supplies it’s production!(yeah like getting old and/or fat)
Plain and simple however it appears your stuck on it being a cure all! It’s my hope if you get a script for it. I just hope your dad don’t have to pay the price!
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