Meta Study Fails to Link Saturated Fat, Heart Disease

The discussion of the Linus Pauling vitamin C/lysine invention for chronic scurvy

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Meta Study Fails to Link Saturated Fat, Heart Disease

Post Number:#1  Post by ofonorow » Sat Feb 06, 2010 4:44 am

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Ralph Lotz
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Re: Meta Study Fails to Link Saturated Fat, Heart Disease

Post Number:#2  Post by Ralph Lotz » Sat Feb 06, 2010 10:50 am

So much for evidence based medicine. And still pushing the "Prudent Diet."
If they don't like the evidence, it is sidestepped and dismissed just as it was in 1966:

It was in the same year, 1966, that the results of Dr. Jolliffe's Anti-Coronary Club experiment were published in the Journal of the American Medical Association.12 Those on the Prudent Diet of corn oil, margarine, fish, chicken and cold cereal had an average serum cholesterol of 220, compared to 250 in the meat-and-potatoes control group. However, the study authors were obliged to note that there were eight deaths from heart disease among Dr. Jolliffe's Prudent Diet group, and none among those who ate meat three times a day. Dr. Jolliffe was dead by this time. He succumbed in 1961 from a vascular thrombosis, although the obituaries listed the cause of death as complications from diabetes.

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Re: Meta Study Fails to Link Saturated Fat, Heart Disease

Post Number:#3  Post by godsilove » Sun Feb 07, 2010 10:41 am

The recent review of prospective cohort studies in AJCN is consistent with the findings of a systematic review published last year in the Archives of Internal Medicine:
We conducted a systematic search of MEDLINE for prospective cohort studies or randomized trials investigating dietary exposures in relation to CHD. We used the Bradford Hill guidelines to derive a causation score based on 4 criteria (strength, consistency, temporality, and coherence) for each dietary exposure in cohort studies and examined for consistency with the findings of randomized trials....Insufficient evidence (< or =2 criteria) of association is present for intake of...saturated and polyunsaturated fatty acids; total fat


It's definitely food for thought; however, one issue that many cohort studies do not address is whether people are replacing saturated fat with an increased intake of refined carbohydrates. This does not necessarily absolve saturated fat, but it does call into question the effectiveness of any recommendations to lower saturated fat without addressing other dietary components. In the AIM review, the authors concluded that there was strong evidence that foods with a high glycemic index have a harmful effect on coronary heart disease.

There is some evidence from randomized trials that replacing saturated fat specifically with PUFAs yields some benefit. Another interesting review by Hu and Willet (2002) concluded that:
Compelling evidence from metabolic studies, epidemiologic investigations, and clinical trials in the past several decades converges to indicate that at least 3 dietary strategies are effective in preventing CHD: substitute unsaturated fats (especially polyunsaturated fat) for saturated and trans-fats; increase consumption of omega-3 fatty acids from fish oil or plant sources; and consume a diet high in fruits, vegetables, nuts, and whole grains and low in refined grains. A combination of these approaches can confer greater benefits than a single approach. However, simply lowering the percentage of energy from total fat in the diet is unlikely to improve lipid profile or reduce CHD incidence.

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Re: Meta Study Fails to Link Saturated Fat, Heart Disease

Post Number:#4  Post by Ralph Lotz » Mon Feb 22, 2010 2:02 pm

A combination of these approaches can confer greater benefits than a single approach


This is especially true if one reduces omega 6 fats found in corn oil. soybean oil and safflower oil:

Our studies suggest that omega-6 fatty acids, and especially linoleic acid, cause endothelial cell dysfunction most
markedly as well as can potentiate TNF-mediated endothelial cell injury. We propose that high-energy diets, and
especially diets rich in linoleic acid, are atherogenic by contributing to an imbalance in cellular oxidative stress/
antioxidant status of the endothelium, which can lead to activation of oxidative stress-responsive transcription factors,
inflammatory cytokine production and the expression of adhesion molecules...

High-Energy Diets, Fatty Acids and Endothelial Cell
Function: Implications for Atherosclerosis
http://www.jacn.org/cgi/reprint/20/2/97.pdf
"Unless we put medical freedom into the constitution...medicine will organize into an undercover dictatorship..force people who wish doctors and treatment of their own choice to submit to only what..dictating outfit offers." Dr. Benjamin Rush


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