Combined vitamin C and E deficiency increases atherosclerosi

[rasarver]

Combined vitamin C and E deficiency increases atherosclerosis in mouse model
http://www.lef.org/whatshot/2010_08.htm ... ouse-model is an article by the Life Extension Foundation.

[ofonorow]

Thank you for finding this. When they say, "Mice bred" for this kind of study, do you know what they mean? There are now strains of mice which do not make their own vitamin C. These mice would be ideal study subjects.

[rasarver]

No, I didn't know that. Thanks for the info.

[Ralph Lotz]

"

Mice bred" for this kind of study, do you know what they mean?

I missed any practical relevance of this study to people in the real world other than those with familial hypercholesterolemia or a family history of early onset alzheimers. (or rats that have been bred to be FUBAR)

In this study there were 2 groups of mice that were apolipoprotein-E deficient and gulonolactone oxidase deficient. The second group was also SVCT2 (the vitamin C transporter) disabled.
The diets were 16% fat and .2% cholesterol.

Combined Vitamin C and Vitamin E Deficiency Worsens Early Atherosclerosis in Apolipoprotein E-Deficient Mice
http://www.ncbi.nlm.nih.gov/pubmed/20558818