Vitamin C Forum

My Dad has 70% blockage and stage 3 kidney disease. His Doctors wanted him to have a triple bypass and to put him on Heparin. My dad refused the surgery and we ordered the Ascorsine-9 product. My brother had some concerns for the high lysine levels for his kidneys.. Just this week, my Dad was rushed to the emergency because my Aunt had given him some Chinese herbs to lower his blood pressure along with his prescriptions. My dad\'s potassium level reached 7.4 and his bp was 80 and his pulse was 39...His condition is stable now...But he is hesitant or scared now to take alternative therapy because of what happened. What is a good regimen for his dosage on Pauling Therapy...thanks for your time...

Respectfully

Chao

my Dad was rushed to the emergency because my Aunt had given him some Chinese herbs to lower his blood pressure along with his prescriptions

Jacquie wrote:N-acetyl-cysteine has shown excellent results in protecting dog and rat kidneys from injury (there are like a billion studies on PubMed supporting this). Some human trials have shown good results as well (although now, of course, everyone's backtracking and saying it doesn't really work ). Since NAC has never caused any harm, even to failing kidneys (all studies show this), it's well worth a try. As always, dose matters a lot.

ofonorow wrote:And putting all this knowledge together - NAC would be expected to work its magic by increasing intracellular glutathione.

Acetaminophen (APAP) overdose is a major cause of acute liver failure. The glutathione (GSH) precursor N-acetylcysteine (NAC) is used to treat patients with APAP overdose for up to 48 hours.

...However, GSH (-82%) was more effective than NAC (-46%) in preventing liver injury.

...NAC treatment was less effective [than GSH] in recovering ATP and mitochondrial GSH levels and showed reduced substrate flux through the Krebs cycle compared with GSH. However, increasing the dose of NAC improved the protective effect similar to GSH...

ofonorow wrote:Thus another logical method presents itself - using liposomal GSH - such as livonlabs Lypo-GSH.

...However, GSH (-82%) was more effective than NAC (-46%) in preventing liver injury.

I don't know if NAC protects the kidneys directly, or as a precursor to GSH (or both), but regardless, this seems like a good idea!

Cysteine has a neurotoxic effect at concentrations
high enough to activate NMDA receptors, leading to
enhanced glutamate neurotoxicity (106), whereas NAC
acts as a precursor for GSH synthesis by supplying
cysteine (47) and activates the GSH cycle (107). NAC
enters cells readily and is then deacetylated to form Lcysteine regardless of the presence or absence of
EAAC1 (16). NAC also exerts a direct chemical effect
as an antioxidant, although with less potency than GSH
(22). Systemic administration of NAC can deliver
cysteine to the brain, thereby raising the GSH level in the
CNS (16). There are, in fact, reports of systemic NAC
administration being beneficial in animal models with
neurological disorders (108, 109). Our recent study
(110) also showed NAC to be an effective precursor
for GSH synthesis in dopaminergic neurons. NAC preadministration ameliorated motor dysfunction in
addition to restoring GSH levels in MPTP-treated mice.
We also found the nitrotyrosine level on EAAC1 to be
lower in the midbrains of NAC/MPTP-treated mice than
in those of MPTP-treated mice. Although we do not yet
know whether NAC would be clinically beneficial in
PD, its low toxicity and ease of administration warrant
further investigation of this compound

...However, GSH (-82%) was more effective than NAC (-46%) in preventing liver injury.