The reproduction of atherosclerosis fulfilling the morophological criteria has centered about increasing either the endogenous or exogenous cholesterol of the experimental animal. …. Although the artery is not interfered with directly, the hypercholesterolaemia and lipid deposits in the reticulo-endotheilal system have no counterpart in man....
Willis - 1953
Willis wrote:I have shown in two rabbits that cholesterol feeding produces a relative depletion of ascorbic acid (this animal can synthesize ascorbic acid) as measured by the intradermal dye injection method of Rotter using the modification of Slobody. This effect was also seen in cholesterol-fed guinea pigs receiving ascorbic acid by mouth. This may possibly be the way in which cholesterol produces ground substance injury under conditions of hypercholesterolaemia.
Anichkov fed cholesterol to rabbits, which supposedly gave them intimal/human-like atherosclerosis. Later, other researchers found that feeding cholesterol to dogs doesn't cause atherosclerosis unless you remove their thyroids.
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