The question Pauling would ask, is serrapeptase "orthomolecular" in the sense that vitamin C and lysine are? Your body requires both vitamin and lysine in some amount daily - for life itself. So your liver and kidneys (and tissues) are familiar with these molecules. (Does your body require serrapeptase?) In other words, does you liver and kidney know what to do with the molecule?
If it works for you regarding "arthritis" - arguably a "hormone deficiency" syndrome or condition -- please let us know. (In my opinion, arthritis is caused by your adrenal glands not making enough of the hormone cortisol. In a nutshell, your doctors will know little to nothing about this because if you are alive, you are producing some amount of cortisol daily. You cannot live more than 24 hours without cortisol. (Ref: Safe Uses of Cortisol, 3rd Edition, William Mck Jefferies) And cortisol levels vary throughout the day and it is hard (inconvenient) to measure blood levels all day long.
But if you suffer arthritis pain, unless some nutrient deficiency is causing your adrenal gland impairment (e.g. too little vitamin C) the only way to relieve the pain and live a normal life is from SAFE cortisol replacement therapy. Where do you live? In the eastern USA their is a group of experts headed by T. Pinkus who can recommend knowledgeable docs, and if you happen to live in the Chicago area, I can recommend one or two docs who have been "trained" and will be able to safely relieve your arthritis pain.
The only reason I am not now in a wheel chair (or on NSAIDS 24/7) is because of my bioidentical hydrocortisone (cortisol) hormone replacement therapy. The universe spent a lot of time teaching me what the problem is - and I am sharing the knowledge (for which a Nobel prize was awarded circa 1952 to the Mayo Clinic.)
Owen R. Fonorow, Orthomolecular Naturopath