Moderator: ofonorow
'Micronutrients'
Mitabolic Tuning - Prevention - Therapy
by Uwe Gröber
2011 edition
Special Interactions:
Acetylsalicylic acid: ASS may lower vitamin C level in blood and white blood-cells.
Bortezomib: In animal-trials oral vitamin C hinders the tumor-destructive effects of protease-inhibitors.
Iron: Vitamin C improves the absorption of non-heme iron through reduction of Fe3+ to Fe2+, as well as through chelation of iron.
Copper: Long-duration high dose vitamin C doses may lower copper absorption and coerulo-plasmin levels.
Selen (Sodiumselenite): Vitamin C may reduce the absorption of Sodiumselenite (take 1-2 hrs apart).
Vitamin E: Intake of vitamin E raises vitamin C needs. In investigations with non-smokers and vitamin E doses > 500mg/day there was an decline of vitamin C plasma-levels of up to 40%.
Zytostatika: In animal-trials the combined intake of Doxorubicin with a peri-enteral application of vitamin C (2g/kg body weight, i.v. or intra-peritoneal) could reduce the cardio-toxic side-effects of Antrazyklins and increase survival-time significantly. Thereby the zytotoxic effect of the Anthorazyklins wasn't reduced. Pharmacological in-vitro studies have further shown, that vitamin C increases the zytotoxic effects of anti-neoplastic substances like Cisplatin, Dacarbazin, Doxorubicin, Gemcitabin, Pactitaxel, Tamoxiflen and 5-Flourouracil (5-FU).
Contra Indications:
Oxalat-Urolithiasis, Iron-storage illnesses (Thalassemia, Hemochromatose); High-dose applications: Glucose-6-P-Dehdrogenase-insufficiency (G6ODG-insufficiency), kidney-insufficiency.
Note:
High vitamin C doses may disturb the determination of clinic parameters in urine (glucose, uric acid, creatinine, inorganic phosphate) and of occult blood in bowel movements.
Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.
Interactions with Drugs
* Vitamin C may increase adverse effects associated with acetaminophen or aluminum-containing antacids such as aluminum hydroxide (Maalox®, Gaviscon®).
* Vitamin C may increase blood levels and adverse effects of aspirin, whereas aspirin may decrease blood levels of vitamin C.
* The effects of vitamin C may be decreased by barbiturates including phenobarbital (Luminal®, Donnatal®), pentobarbital (Nembutal®), or secobarbital (Seconal®).
* Vitamin C supplementation may decrease levels of the drug fluphenazine in the body.
* Concomitant administration of high doses of vitamin C can reduce steady-state indinavir plasma concentrations.
* There is limited case report evidence that high dose vitamin C may reduce side effects of levodopa therapy such as nausea or malcoordination.
* Nicotine products such as cigarettes, cigars, chewing tobacco, or nicotine patches may decrease the effects of vitamin C.
* Oral estrogens may decrease the effects of vitamin C in the body. When taken together, vitamin C may increase blood levels of ethinyl estradiol.
* The effects of vitamin C may be decreased by tetracycline antibiotics such as doxycycline (Vibramycin®), minocycline (Minocin®), or tetracycline (Sumycin®).
* Vitamin C in high doses appears to interfere with the blood thinning effects of warfarin by lowering prothrombin time (PT), as noted in case reports in the 1970s. Complications have not been reported (such as increased blood clots).
* High doses of vitamin C are not recommended in patients with kidney failure. Caution is advised when taking vitamin C and drugs that may damage the kidneys due to an increased risk of kidney failure.
Interactions with Herbs and Dietary Supplements
* When taken together, vitamin C may increase the absorption of iron in the gastrointestinal tract, although this effect appears to be variable and may not be clinically significant.
* Vitamin C may increase absorption of lutein vitamin supplements.
* Large doses of vitamin C may interfere with the absorption and metabolism of vitamin B12.
* In theory, large doses of vitamin C may also interact with herbs and supplements with hormonal, antibacterial and blood thinning (anticoagulant) activity.
* Caution is advised when taking vitamin C and agents that may damage the kidneys due to an increased risk of kidney failure.
Author Information
* This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (http://www.naturalstandard.com).
•Some people using mega dose therapy of vitamin C may have side effects such as gastrointestinal complaints including diarrhea, nausea and abdominal cramps.
majkinetor wrote:The most known interaction is with aspirin (easily prevented by not taking them together). Synergic effect may cause an increased bleeding in the digestive tract. Aspirin is one of the drugs that is for instance regularly prescribed to prevent heart attacks, strokes, and blood clot formation. This is especially important since Pauling Therapy may be used in parallel with allophatic therapy for CVD witch might include Aspirin.
Vitamin C may also reverse anticoagulant activity of warfarin.
Vitamin C, Its Chemistry and Biochemistry, Page 89.
"A significant role is played by oxidizing enzymes associated with the microsomal fraction, notably a cytochrome called P450 which is a mixed function oxidase (MFO). This very broad-specificity enzyme, which helps dispose of ethanol, benzene, tetracholromethane, and polychlroinated biphenyls (PCBs) to name but four notorious toxins, may depend for its action on the presence of vitamin C since...."
Owen wrote:As far as the idea that vitamin C can counteract the anticoagulant activity of rat poison (warfarin) I would appreciate a reference.
Walfarin and Related Oral Vitamin K Antagonist Antikoogulants
From "Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies by Mitchell Bebel Stargrove ND". Data from some, but not all, animal experiments and rare, unqualified case reports indicates that vitamin C, in high doses, might decrease functional level and therapeutic acdtivity of warfarin, but the cumulative body of evidence fails to support a well-founded, consistent, and generalizable conclusion.
Findings from the four controlled trials involving large number of subjects indicate a lack of clinically significant interaction between warfarin and ascorbic acid, event at doses as high as 10g vitamin C per day.
Read...
Owen wrote:I know that Irwin Stone and others cited research to the contrary, that because of the risk of bleeding, all doctors should recommend vitamin C be taken with aspirin as a matter of course.
Owen wrote:So the answer to the question is that although we cannot prove a negative, taking vitamin C along with a drug is generally favorable, with few or no known contraindications.
Findings from the four controlled trials involving large number of subjects indicate a lack of clinically significant interaction between warfarin and ascorbic acid, event at doses as high as 10g vitamin C per day.
I admit I am still a little confused as your reference seem to make my point?
Travell & Simons' myofascial pain and dysfunction wrote:VITAMIN C AND ASPIRIN. The increased capillary fragility characteristic of a low serum vitamin C level can cause excessive bleeding in muscles injected for TrPs. Cap illary hemorrhage augments postinjection soreness and leads to unsightly ecchy moses. A frequent source of increased bleeding due to low vitamin C is tobacco. Megadose vitamin C therapy daily for 1 week should correct this deficiency. At least 500 mg of timedrelease vitamin C three times daily is recommended for a minimum of 3 days prior to injection of TrPs. The im portance of vitamin C for smokers was re viewed in Section 12 of this chapter. A daily dose of aspirin increases the susceptibility to bleeding. The patient should take no aspirin for 3 days before TrP injection or needling.
.....
Although megadoses of vitamin C have been identified as theoretically causing cystine and oxalate stones in the urinary
tract , it is becoming apparent that patients with normal renal function can tolerate exceptionally high dosage of vitamin C. One patient took 15 g of vitamin C daily for 4 months without ill effects.
Taking an aspirin a day to prevent heart attacks and strokes causes blood loss via the digestive tract on the order of about a tablespoon per day. This results in iron loss.
Users browsing this forum: No registered users and 30 guests