It's good to be a doubting Thomas but one can look a bit silly .
Since you are asking only for "clinical proof", I will just mention my long association with the two founders of Orthomolecular Medicine and my clinical experience of over thirty years.
When Pauling told me ages ago that rebound scurvy is something to be reckoned with I had no doubts about the veracity of the statement. Nor do I have any now.
When I have concerns about these things I ask those who do know best.
THE REBOUND EFFECT
When a person regularly ingests about 150 mg of vitamin C per day the ascorbate concentration in the blood plasma is about 1.5 mg per 100 milli?liters. It was observed in 1973 (Harris, Robinson, and Pauling; Spero and Anderson) that when the amount ingested is increased to several grams per day the plasma ascorbate concentration rises to about 2.5 mg per 100 milli?liters and then, with the same high intake, decreases over a few days to about the original value, 1.5.
This phenomenon is well known in bacteria. It is called induced enzyme formation. In the case of vitamin C in human beings, we assume that there are enzymes that help to convert ascorbate to certain oxidation products. It is known that these oxidation products serve a useful purpose?they have been shown to have anticancer activity in mice, and presumably are similarly effective in human beings. The ascorbate itself also is valuable, and accord?ingly on a low intake the body manufactures only a small number of the enzyme molecules, in order to conserve the ascorbate. When the high intake is begun more enzyme molecules are manufactured, in order to convert the extra ascorbate to the useful oxidation products, instead of simply allowing the excess to be excreted in the urine. These oxidation products, which as yet have not been thoroughly studied, may provide an important part of the mechanism by which large doses of vitamin C help to control cancer and other diseases.
From the foregoing argument we would expect that when a person who has been on a high intake of vitamin C for some time suddenly reverts to his original low intake the enzymes, present in large number, would operate to convert most of the ingested ascorbate to its oxidation products, leaving him with a dangerously low concentration of ascorbate in the blood. This effect has been observed; it is called the rebound effect. It lasts for only a few days. by which time the enzyme molecules present in excess have been destroyed and the number remaining has reached the value appropriate to the low intake. There is some evidence that during the period of the rebound effect the susceptibility to infections is increased; the control of cancer might also be less at this time. It is accordingly recommended that a high intake of vitamin C not be suddenly stopped, even for one day; instead it should be gradually decreased, over a period of several days, if a decrease is deemed to be necessary.
Furthermore Dottore, your arguments appeal to authority, but how do we know that you aren't really Stephen Barrett writing from his basement in Allentown PA? Forum memebers judge other members by what they write and know, not who they claim to know.
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