Ascorbic Acid versus Natural Vitamin C and C-complex

What is vitamin C? Is there such a thing as a vitamin C complex? Why do so many people now believe in the complex?

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Re: Ascorbic Acid versus Natural Vitamin C and C-complex

Post Number:#16  Post by ToMyFriendsHealth » Sun Sep 11, 2016 7:50 am

From Albert Svent-Gyorgyi's presentation to the Nobel Committee in 1937 before his award for the Nobel Prize. Notice the comments on the vitamin P component. C, I'm sorry, is not ascorbic acid.

...At the time that I had just detected the rich vitamin content of the paprika, I was asked by a colleague of mine for pure vitamin C. This colleague him- self suffered from a serious haemorrhagic diathesis. Since I still did not have enough of this crystalline substance at my disposal then, I sent him paprikas. My colleague was cured. But later we tried in vain to obtain the same thera- peutic effect with pure vitamin C. Guided by my earlier studies into the peroxidase system, I investigated with my friend St. Rusznyák and his collaborators Armentano and Bentsáth the effect of the other link in the chain, the flavones. Certain members of this group of substances, the flava- none hesperidin (Fig. 5) and the formerly unknown eriodictyolglycoside, a mixture of which we had isolated from lemons and named citrin, now had the same therapeutic effect as paprika itself. It is still too early on in our experience for us to make any definitive statements. But it does seem that these substances possess great biological activity. They influence most ob-

viously the capillary blood vessels, whose permeability and resistance suffer gravely in many disease states. These dyes are able to restore the state of affairs to normal, and to judge by the first experiences, it seems that these substances will enrich the doctor’s inventory with a really useful new weapon for him to fight illnesses with. Our experiments made it probable that cer- tain members of this group possess vitamin-like properties. For this reason I called the substance vitamin P. Unfortunately these vitamin-like properties have not yet been successfully demonstrated in a completely irreproachable and reproducible fashion....

Notice the comment on the Vitamin P component.

It's a complex and not an isolate. ... ecture.pdf

And from the presentation speech by Professor E. Hammarsten, member of the Staff of Professors of the Royal Caroline Institute, on December 10, 1937 ... press.html

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Re: Ascorbic Acid versus Natural Vitamin C and C-complex

Post Number:#17  Post by OxC » Mon Jan 16, 2017 4:14 pm

The debate among common folks over synthetic versus natural ascorbic acid continues, while the consensus among scientists is expressed well in the following two quotes from an earlier post:
A. Hoffer wrote:...I was very surprised by the argument that there is only a vitamin C complex and no such substance as vitamin C. In my opinion this is not a scientific matter but an important advertising problem...Synthetic vitamin C is bio-identical...

Steve Lawson wrote:...I was unaware that any such controversy about vitamin C exists. Actually, among scientists, there is no controversy about “natural” and “synthetic” vitamin C: it is exactly the same molecule, regardless of source. As far as vitamin C activity is concerned, the only substance in the so-called “vitamin C complex” that provides this is ascorbic acid. This has been well established for many decades and is not in question among professional scientists.

But most scientists today recognize that "dietary vitamin C" is not synonymous with "dietary ascorbic acid," but is instead "the sum of dietary ascorbic acid and dehydroascorbic acid."

Therefore the question, "Are synthetic and natural ascorbic acid identical?" is not the same question as, "Are synthetic and natural vitamin C identical?" Ascorbic acid as found in food is the same molecule as synthetic ascorbic acid. However, vitamin C as found in food is only partially in the form of ascorbic acid. About 10-20% of the vitamin C we ingest from food is dehydroascorbic acid. For example:
(Table 3 from this paper: An Improved Sample Preparation Method for Quantification of Ascorbic Acid and Dehydroascrobic Acid by HPLC. -- Food Science and Technology (2012)).

The point being that most dietary supplements only provide one of the two common forms of vitamin C found in the diet, and this is the most likely difference in the many studies that have shown better results when vitamin C was taken as food versus supplements. A famous example of a study demonstrating a difference between vitamin C from food (in this case, lemon juice) versus synthetic vitamin C is found here THE INADEQUACY OF SYNTHETIC ASCORBIC ACID AS AN ANTISCORBUTIC AGENT. Elmby and Warburg, The Lancet, (1937)
Douglas Q. Kitt, founder of ReCverin LLC, sellers of stabilized dehydroascorbic acid solutions.

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