Article: The importance of vitamin C in the incidence of atrial fibrillation
Author: Keller, Kathryn Buchanan KB
Journal: American journal of critical care
ISSN: 1062-3264 Date: 05/2008
Volume: 17 Issue: 3 Page: 270
I stumbled across this article, which I like because it gently tries to educate heart doctors/surgeons on the benefits of vitamin C for their patients. However, I noticed that there isn't even an abstract in Medline for ordinary users. But if you are a medical professional with medical library priviliges, you should be able access this article. Here are the highlights
Additionally, vitamin C reduces the development of nitrate tolerance.4 2. c. vitamin C may play a role in preventing postoperative AF d. atrial remodeling may be caused by oxidative stress Atrial fibrillation, a common arrhythmia following cardiac surgery, has an incidence of 20% to 30% that is even greater following valvular heart procedures.
Atrial fibrillation, which in the past was considered to be a transient and benign arrhythmia, is actually a significant cause of postoperative morbidity and mortality. Postoperative patients in whom AF develops have an increased incidence of strokes and perioperative myocardial infarction, are prone to development of congestive heart failure and respiratory failure, and thus are at an increased risk of mortality.5,6 Postoperative AF is a major cause of morbidity and mortality in cardiac surgery and increases the length of stay in the intensive care unit, as well as total hospitalization, by approximately 3 days.5 Inhospital mortality and long-term mortality (5 years) are also increased.6 The pharmacological agents used in the prevention of postoperative AF brought modest results. These include β-blockers, sotalolol, and amiodarone.
The role of vitamin C was studied in 100 randomized patients undergoing coronary bypass surgery; half received ascorbic acid and a β-blocker preoperatively and postoperatively, and the other half received only a β-blocker.7 The group that received both vitamin C and a β-blocker had a 4% incidence of AF compared with 25% in the control group.
Additional studies have reported similar findings. In a study 8 (2005) on the role of vitamin C in the prevention of early recurrence of AF following cardioversion, AF recurred in 4.5% of patients pretreated with vitamin C, compared with 36.3% in the control group. The control group treated with vitamin C had a significant reduction in serum inflammatory indices, such as white blood cell count, fibrinogen level, and level of C-reactive protein.8