Vitamin C's Role In Combatting Hypertension

Answers to questions about vitamin C and its relation to all forms of cardiovascular disease

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Seymore Spectacles

Vitamin C's Role In Combatting Hypertension

Post Number:#1  Post by Seymore Spectacles » Sat Apr 19, 2008 11:58 am

Objective: Hypertension is a common condition with
high mortality from associated diseases. Epidemiological
evidence suggests that a dietary deficiency of vitamin C
may be a risk factor for hypertension. However, it remains
unclear whether vitamin C supplementation could reduce
blood pressure.

Therefore, the purpose of this study was to
provide a comprehensive meta-analysis using randomized,
controlled trials looking at the effect of vitamin C supplementation
on blood pressure in patients with hypertension.

Nine randomized, controlled trials published
between 1966 and August 2007 with a total of 297 participants
were identified using MEDLINE and a manual
search. Using a random effects model, the effect sizes of
vitamin C supplementation on systolic and diastolic blood
pressure changes were estimated.

Results: Vitamin C supplementation was associated
with a significant reduction in systolic blood pressure with
an effect size of -2.37 mm Hg (95 % CI, -3.14 to -1.6 mm
Hg). However, the mean change in diastolic blood pressure
was non-significant with an effect size of only -0.37 mmHg
(95 % CI, -1.5 to 0.76 mm Hg).

Conclusion: Vitamin C supplementation in hypertensive
patients appears to possess modest effects on reducing
systolic blood pressure. (issue: JANA Volume 11, No. 1, 2008)

Seymore Spectacles

Re: Vitamin C's Role In Combatting Hypertension

Post Number:#2  Post by Seymore Spectacles » Sun Sep 21, 2008 12:39 pm

Vitamin C lowers blood pressure

By Sue Mueller

Sep 20, 2008 - 6:46:49 PM

Saturday Sep 20 2008 ( -- Got hypertension? It may be time to try intravenous injection of vitamin C. A new Italian study found that vitamin C intravenously delivered can lower blood pressure by acting on an overactive central nervous system.

Dr. Rosa Maria Bruno from the University of Pisa, coauthor of the study, was quoted by as saying "our study demonstrated for the first time in humans that we can reduce sympathetic nervous system over-activity, and consequently blood pressure, (by) targeting oxidative stress."

The sympathetic nervous system (SNS) is part of the central nervous system that controls blood pressure among other things. Low activity of the SNS is coupled with the onset of elevated blood pressure.

The finding was presented Friday at the American Heart Association's Conference of the Council for High Blood Pressure Research held in Atlanta.

Early studies have already showed that vitamin C and potentially other antioxidants in the blood may help lower the risk of stroke.

The current study involved 12 patients with an essential form of high blood pressure who had not received any treatment for their high blood pressure. All the participants were intravenously administered three grams of vitamin C during a period of five minutes and then monitored for blood pressure and SNS activity for 20 minutes.

It was found that SNS activity dropped by 11 percent and blood pressure was lowered by about 7 percent on average. The decrease in diastolic blood pressure was 9 percent while systolic blood pressure did not change significantly. ... sure.shtml

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