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 Ginter: High Vitamin C Lowers Elevated Cholesterol 
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Ascorbate Wizard
Ascorbate Wizard

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Post Ginter: High Vitamin C Lowers Elevated Cholesterol
There is an inverse relationship between vitamin C intake and cholesterol levels in man according to the leading world expert, the Russian, E. Ginter.

This post is devoted to Ginter's work, which predicts, among other things, that total cholesterol normalizes to 180 mg/dl (as cited by Pauling in his book HTLLAFB).

Unfortunately, although most of Ginter’s work are cited in MEDLINE, most are missing abstracts! What follows are a few studies that we are fortunate to have translations. They illustrate that low vitamin C elevates cholesterol, in guinea pigs and man. More importantly, that high vitamin C intake lowers cholesterol, and lowers cardiovascular disease mortality.
.

http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
Effect of ascorbic acid on plasma cholesterol in humans in a long-term experiment.
Ginter E, Cerna O, Budlovsky J, Balaz V, Hruba F, Roch V, Sasko E.

Ginter, et al wrote:
During the period of a low vitamin C intake (approximately equal to 20 mg per day) ascorbic acid in a dose of 2 x 500 mg per day was administered to 82 men and women aged 50-75 years. A correlation of plasma cholesterol levels determined before and after a three months' administration of ascorbic acid showed the effect of vitamin C to be dependent on the starting concentration of plasma cholesterol: the higher the initial cholesterolemia, the greater the hypocholesterolemic effect of ascorbic acid. On restricting the experimental group to subjects with an initial cholesterolemia above 230 mg%, the effect of the same dose of ascorbic acid on cholesterolemia was followed in three-month periods for a further 9 months. In all these time intervals, ascorbic acid was found significantly to depress cholesterolemia and its effects persisted 6 weeks after termination of the experiment.

The administration of 2 x 500 mg ascorbic acid daily during one year resulted in an abrupt increase of ascorbemia and a marked accumulation of ascorbic acid in the leucocytes. Six weeks following interruption of ascorbic acid intake, vitamin C concentration in the leucocytes significantly declined but still continued to be twice higher than in the control receiving no ascorbic acid supplement.


http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
Vitamin C in the control of hypercholesterolemia in man.

Ginter E, Bobek P, Kubec F, Vozar J, Urbanova D.

Ginter, et al wrote:
The activity of the cholesterol 7 alpha-hydroxylating system containing cyto-chrome P-450 is depressed in the liver of guinea-pigs with chronic marginal vitamin C deficiency. Slowing-down of this rate-limiting reaction of cholesterol transformation to bile acids causes cholesterol accumulation in the liver, blood plasma and arteries, increase in the index total: HDL cholesterol, prolongation of plasma cholesterol half-life, increase in the index cholesterol: bile acids in the gall-bladder bile, cholesterol gallstone formation and atheromatous changes on coronary arteries in guinea-pigs with long-lasting marginal vitamin C deficiency.

The most effective means for preventing these changes are vitamin C doses ensuring maximal steady-state levels of ascorbate in the tissues. In most of hypercholesterolemic persons with a low vitamin C status, the administration of ascorbic acid in doses 500-1000 mg per day lowers total cholesterol concentration in blood plasma.

This effect may be reinforced through a simultaneous administration of bile acids sequestrants, such as cholestyramine or pectin. In every form of hypercholesterolemia therapy (dietary and/or pharmacological), an adequate vitamin C supply should be ensured in doses capable of creating maximal steady-state levels of ascorbate in human tissues.



http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
Ascorbic acid in cholesterol and bile acid metabolism.

Ginter E.
Ginter wrote:
Latent chronic ascorbic acid deficiency provokes in guinea pigs a metabolic disorder in the liver, causing an impaired cholesterol transformation to its principal catabolic product, bile acids. This metabolic disorder induces hypercholesterolemia and accumulation of cholesterol in the liver and slows the release of cholesterol from the circulation. Ascorbic acid probably intervenes into the biosynthesis of bile acids at the stage of 7 alpha-hydroxylation of the cholesterol nucleus. High doses of ascorbic acid significantly stimulate cholesterol transformation to bile acids in guinea pigs and decrease plasma cholesterol concentration in humans.


http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
Effect of long-term marginal vitamin C deficiency on plasma triglyceride kinetics in guinea-pigs.
Bobek P, Ginter E, Ozdin L, Poledne R, Potucek J.

Ginter, et al wrote:
A multicompartmental analysis of the plasma triglyceride kinetics after [3H]glycerol administration revealed that hypertriglyceridemia in vitamin c deficient guinea-pigs was caused by a slowed triglyceride removal from the plasma compartment


http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
Plasma lipids, lipoproteins and atherogenic index in men and women administered vitamin C.
Cerna O, Ramacsay L, Ginter E.

Research Institute of Human Nutrition, Comenius University College of Physical Education, Bratislava, Czechoslovakia.

Ginter, et. al wrote:
The aim of the study was to establish whether it is possible, in a group of deliberately selected subjects with hyperlipidaemia, to modulate cholesterol levels by ascorbic acid administered at a dose of 500 mg/day.

The authors assessed the levels of vitamin C, total and HDL cholesterol, triacylglycerols in the blood serum of 140 probands assigned to an 83-member experimental group, and to a 57-member control group. The experimental group was provided Celaskon effervescens Spofa at a dose of 500 mg/day/person. The experiment lasted for 18 months. Blood collections were made in the whole cohort at six-month intervals. Administration of L-ascorbic acid led to a highly significant decrease in the levels of total and LDL cholesterol.

After 12 months of study, a highly significant decrease in atherogenic index and an increase in HDL cholesterol levels were found persisting until the end of the experiment.


http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
The effect of graded ascorbic acid intake on the activity of GSH-Px in the liver of female guinea pigs.

Kovacikova Z, Ginter E, Madaric A.

Institute of Clinical and Preventive Medicine, Bratislava, Slovak Republic.
Ginter wrote:
Differing antioxidant potentials created by graded ascorbic acid supplementation (1, 10, 100 mg per animal daily) evoked changes in the level of glutathione peroxidase activity and lipid peroxides in the liver of female guinea pigs. The group with the lowest ascorbic acid intake (1 mg) had the lowest activity of glutathione peroxidase and the highest level of lipid peroxides. The two other groups (10 and 100 mg) showed enhancement of glutathione peroxidase activity and decline in lipid peroxides. There was no difference between the groups with 10 and 100 mg ascorbic acid intake.



The next two studies show how vitamin C protects the liver.

http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
Influence of vitamin C status on the metabolic rate of a single dose of ethanol-1-(14)C in guinea pigs.

Ginter E, Zloch Z.

Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
Ginter wrote:
The rate of oxidative metabolism after a single i.p. dose of ethanol-1-(14)C was studied in male guinea pigs, previously treated with two different levels of vitamin C (traces or 0.5 g/100 g) in their diet for 5 weeks. While the body weight did not differ between these two groups after 5 weeks of the dietary regimen, the vitamin C concentration in the liver was five times higher in the group with the high vitamin C intake. The cumulative amounts of breathing 14CO2 measured at short time intervals during 24 hours after an ethanol-14C injection (23 mg ethanol and 160 kBq per kg body weight or 2.35 g ethanol and 165 kBq per kg body weight in a parallel experiment) were significantly different. The half-time of ethanol turnover reached a value of 5.1 h versus 6.9 h (9.9 vs 14.4 h in a parallel experiment) in the high and low saturated group respectively. The long-term pretreatment of guinea pigs with large doses of vitamin C accelerated ethanol metabolism. Improvement of the redox state and activation of the cytochrome P450 system in vitamin C-supplemented organism are considered to be the reason for the increased ethanol catabolism.


http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
Influence of vitamin C status on ethanol metabolism in guinea-pigs.

Ginter E, Zloch Z, Ondreicka R.

Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.

Ginter, et al wrote:
Guinea-pigs were maintained for 5 weeks on a diet containing three different concentrations of vitamin C: a) traces (none added), b) medium (0.05% w/w) and high (0.5% w/w). Twenty-four hours before killing the animals received one i.p. dose of 3 g ethanol per kg body weight (a model of short-term acute intoxication). In a parallel experiment which lasted 5 weeks, the animals were treated every week with two i.p. doses of 1 g ethanol per kg body weight followed by the final acute intoxication (3g ethanol/kg) (a model of long-term chronic alcoholization). In both experiments, the guinea-pigs with the highest tissue concentration of vitamin C proved to have significantly decreased residual levels of ethanol and acetaldehyde in the liver and the brain, a decreased activity of alanine- and aspartate aminoacyl transferases in the serum and decreased contents of triacylglycerols and cholesterol in the serum and liver in comparison with the vitamin C-unsupplemented group. The regression curve expressing vitamin C levels versus residual ethanol and acetaldehyde concentrations in the liver confirmed the highly significant negative correlation between them. Administration of the guinea-pigs with large amounts of vitamin C appears to accelerate ethanol and acetaldehyde metabolism and reduce some of their adverse health effects.




The following Ginter citations in Medline are missing abstracts. What follows is to provide the reader with some idea of the depth of the Ginter research into vitamin C and cholesterol.
Wouldn’t it be wonderful to read the fruits of all these studies.

301:
Ginter E, Jankela J, Nemec R, Bobek P.
Related Articles, Links

[Use of cholesterol-26-14C in the study of the cholesterol distribution in guinea pig tissues]
Cesk Gastroenterol Vyz. 1972 Oct;26(7):304-10. Slovak. No abstract available.
PMID: 5083080 [PubMed - indexed for MEDLINE]


302:
Ginter E, Cerven J, Nemec R, Mikus L, Jankela J.
Related Articles, Links

[2-pool analysis of cholesterol metabolism in normal guinea pigs]
Bratisl Lek Listy. 1972 Oct;58(4):400-7. Slovak. No abstract available.
PMID: 4634332 [PubMed - indexed for MEDLINE]


303:
Ginter E, Nemec R, Bobek P.
Related Articles, Links

Stimulation of (26- 14 C)cholesterol oxidation by ascorbic acid in scorbutic guinea-pigs.
Br J Nutr. 1972 Sep;28(2):205-11. No abstract available.
PMID: 5071684 [PubMed - indexed for MEDLINE]


305:
Ginter E.
Related Articles, Links

Atherosclerosis and vitamin C.Lancet. 1972 Jun 3;1(7762):1233-4. No abstract available.
PMID: 4113213 [PubMed - indexed for MEDLINE]



307:
Ginter E, Zloch Z.
Related Articles, Links

Raised ascorbic acid consumption in cholesterol-fed guinea pigs.
Int J Vitam Nutr Res. 1972;42(1):72-9. No abstract available.
PMID: 5019181 [PubMed - indexed for MEDLINE]


308:
Ginter E, Nemec R.
Related Articles, Links

Dynamics of ascorbic acid stimulation of 26- 14 C cholesterol oxidation in guinea-pigs.
Physiol Bohemoslov. 1972;21(5):539-45. No abstract available.
PMID: 4266223 [PubMed - indexed for MEDLINE]


309:
Ginter E.
Related Articles, Links

Vitamin-C deficiency and gallstone formation.
Lancet. 1971 Nov 27;2(7735):1198-9. No abstract available.
PMID: 4108000 [PubMed - indexed for MEDLINE]


310:
Ginter E, Cerven J, Nemec R, Mikus L.
Related Articles, Links

Lowered cholesterol catabolism in guinea pigs with chronic ascorbic acid deficiency.
Am J Clin Nutr. 1971 Oct;24(10):1238-45. No abstract available.
PMID: 5110544 [PubMed - indexed for MEDLINE]


311:
Zloch Z, Cerven J, Ginter E.
Related Articles, Links

Radiochemical evaluation of the 2,4-dinitrophenyl-hydrazine method for determination of vitamin C.Anal Biochem. 1971 Sep;43(1):99-106. No abstract available.
PMID: 5130415 [PubMed - indexed for MEDLINE]


313:
Ginter E, Zloch Z, Cerven J, Nemec R, Babala J.
Related Articles, Links

Metabolism of L-ascorbic acid-1-14C in guinea pigs with alimentary cholesterol atheromatosis.
J Nutr. 1971 Feb;101(2):197-204. No abstract available.
PMID: 5540440 [PubMed - indexed for MEDLINE]


314:
Ginter E, Ondreicka R.
Related Articles, Links

Liver cholesterol esters composition in guinea pigs with chronic vitamin C deficiency.
Nutr Metab. 1971;13(6):321-30. No abstract available.
PMID: 5148506 [PubMed - indexed for MEDLINE]


315:
Bobek P, Ginter E, Cerven J.
Related Articles, Links

Scintillation spectrometry determination of digitonides of 14 C-labelled cholesterol.
Physiol Bohemoslov. 1971;20(5):523-5. No abstract available.
PMID: 4259134 [PubMed - indexed for MEDLINE]


317:
Zloch Z, Ginter E.
Related Articles, Links

Thin-layer chromatographic determination of L-ascorbic, L-dehydroascorbic nd 2.3-diketo-L-gulonic acids in animal tissues, blood and urine.
Z Klin Chem Klin Biochem. 1970 May;8(3):302-5. No abstract available.
PMID: 5470753 [PubMed - indexed for MEDLINE]


318:
Ginter E, Babala J, Polonyova E.
Related Articles, Links

[Vitamin C and lipid metabolism in rabbits on atherogenic diet]
Biologia (Bratisl). 1970;25(9):579-86. German. No abstract available.
PMID: 5506585 [PubMed - indexed for MEDLINE]


319:
Ginter E, Babala J, Ovecka M, Zloch Z, Ondreicka R.
Related Articles, Links

Biochemical, morphological and haematological changes in guinea-pigs fed with cholesterol diets having a different fatty acid composition.
Cor Vasa. 1970;12(4):291-302. No abstract available.
PMID: 5495428 [PubMed - indexed for MEDLINE]


320:
Ginter E, Kajaba I, Nizner O.
Related Articles, Links

The effect of ascorbic acid on cholesterolemia in healthy subjects with seasonal deficit of vitamin C.
Nutr Metab. 1970;2(2):76-86. No abstract available.
PMID: 5486051 [PubMed - indexed for MEDLINE]


321:
Ginter E.
Related Articles, Links

Effect of dietary cholesterol on vitamin C metabolism in laboratory animals.
Acta Med Acad Sci Hung. 1970;27(1):23-9. No abstract available.
PMID: 5454556 [PubMed - indexed for MEDLINE]


325:
Ginter E, Babala J, Cerven J.
Related Articles, Links

The effect of chronic hypovitaminosis C on the metabolism of cholesterol and atherogenisis in guinea pigs.
J Atheroscler Res. 1969 Nov-Dec;10(3):341-52. No abstract available.
PMID: 5364084 [PubMed - indexed for MEDLINE]


326:
Ginter E, Ondreicka R, Bobek P, Simko V.
Related Articles, Links

The influence of chronic vitamin C deficiency on fatty acid composition of blood serum, liver triglycerides and cholesterol esters in guinea pigs.
J Nutr. 1969 Nov;99(3):261-6. No abstract available.
PMID: 5350979 [PubMed - indexed for MEDLINE]


327:
Ginter E, Nemic R.
Related Articles, Links

Metabolism of (1-14C)acetate in guinea pigs with chronic vitamin C hyposaturation.
J Atheroscler Res. 1969 Sep-Oct;10(2):273-6. No abstract available.
PMID: 5381848 [PubMed - indexed for MEDLINE]


329:
Ginter E, Bobek P, Babala J, Barbierikova E.
Related Articles, Links

The effect of ascorbic acid on the lipid metabolism of guinea-pigs fed an atherogenic diet.
Cor Vasa. 1969;11(1):65-73. No abstract available.
PMID: 5789828 [PubMed - indexed for MEDLINE]


330:
Ginter E, Cerven J, Mikus L.
Related Articles, Links

The effect of chronic hypovitaminosis C on the absorption of cholesterol-4-C14 in guinea pigs.
Physiol Bohemoslov. 1969;18(5):459-61. No abstract available.
PMID: 4246435 [PubMed - indexed for MEDLINE]


331:
Koniukhov BV, Pashin IuV, Ginter EK.
Related Articles, Links

[Study of the primary action of genes in man and vertebrate animals]
Usp Sovrem Biol. 1968 Mar-Apr;65(2):202-18. Review. Russian. No abstract available.
PMID: 4903207 [PubMed - indexed for MEDLINE]


332:
Ginter E, Bobek P, Ovecka M.
Related Articles, Links

Model of chronic hypovitaminosis C in guinea-pigs.
Int Z Vitaminforsch. 1968;38(1):104-13. No abstract available.
PMID: 5726548 [PubMed - indexed for MEDLINE]


333:
Ginter E, Babala J, Bobek P, Dumbalova Z.
Related Articles, Links

Model of experimental hypercholesterolaemia and atherosclerosis in the guinea-pig.
Cor Vasa. 1968;10(2):126-34. No abstract available.
PMID: 5706093 [PubMed - indexed for MEDLINE]


334:
Babala J, Ginter E.
Related Articles, Links

Coronary changes experimentally produced in guinea-pigs by hypercholesterolemia.
Nutr Dieta Eur Rev Nutr Diet. 1968;10(2):133-42. No abstract available.
PMID: 5694880 [PubMed - indexed for MEDLINE]


335:
Ginter E, Bobek P.
Related Articles, Links

[Effect of the frequency of aministration of ascorbic acid on the saturation of guinea pigs with vitamin C]
Biologia (Bratisl). 1968;23(9):721-7. Slovak. No abstract available.
PMID: 5681908 [PubMed - indexed for MEDLINE]


336:
Ginter E.
Related Articles, Links

[Effect of vitamin C on the metabolism of cholesterol and atherogenesis]
Cesk Fysiol. 1968;17(5):423-36. Review. Slovak. No abstract available.
PMID: 4883924 [PubMed - indexed for MEDLINE]


337:
Cerven J, Ginter E.
Related Articles, Links

[The effect of magnesium deficiency on lipid metabolism in rats]
Cesk Gastroenterol Vyz. 1967 Sep;21(6):376-82. Slovak. No abstract available.
PMID: 5006605 [PubMed - indexed for MEDLINE]


340:
Cerven J, Ginter E, Bobek P, Cerey K.
Related Articles, Links

Lipide metabolism in magnesium-deficient rats.
Z Versuchstierkd. 1967;9(5):221-7. No abstract available.
PMID: 5606816 [PubMed - indexed for MEDLINE]


341:
Ginter E, Bobek P, Kopec Z, Ovecka M, Cerey K.
Related Articles, Links

Metabolic disorders in guinea-pigs with chronic vitamin C hyposaturation.
Z Versuchstierkd. 1967;9(5):228-35. No abstract available.
PMID: 5604341 [PubMed - indexed for MEDLINE]


344:
Ginter E.
Related Articles, Links

[Magnesium in nutrition. Review]
Cesk Gastroenterol Vyz. 1967 Jan;21(1):52-3. Review. Slovak. No abstract available.
PMID: 4871517 [PubMed - indexed for MEDLINE]


352:
Ginter E, Bobek P, Babala J.
Related Articles, Links

[Effect of experimental hypercholesteremia on the liver of different laboratory animals]
Epatologia. 1966 Jan-Feb;12(1):23-35. Italian. No abstract available.
PMID: 6004485 [PubMed - indexed for MEDLINE]



357:
Ginter E, Cerven J, Gerbelova M.
Related Articles, Links

Metabolism of phospholipids in scorbutic guinea-pigs.
Experientia. 1965 Sep 15;21(9):503-4. No abstract available.
PMID: 5872603 [PubMed - indexed for MEDLINE]


358:
Ginter E, Bobek P, Gerbelova M.
Related Articles, Links

[The effect of acute deficiency and of prolonged low intake of vitamin C on the spectrum of serum lipoproteins in guinea pigs]
Bratisl Lek Listy. 1965 Jul 15;45(1):11-6. Slovak. No abstract available.
PMID: 5839451 [PubMed - indexed for MEDLINE]


359:
GINTER E, BOBEK P, GERBELOVA M, ONDRECKA R, BILISICS L.
Related Articles, Links

LIPID METABOLISM UNDER CONDITIONS OF ACUTE AND CHRONIC L-ASCORBIC ACID DEFICIENCY IN GUINEA-PIGS.
Physiol Bohemoslov. 1965;14:282-8. No abstract available.
PMID: 14328562 [PubMed - OLDMEDLINE for Pre1966]


361:
Ginter E, Bobek P, Gerbelova M.
Related Articles, Links

The influence of scorbut and prolonged low intake of vitamin C on serum lipoproteins in guinea-pigs.
Nutr Dieta Eur Rev Nutr Diet. 1965;7(2):103-7. No abstract available.
PMID: 5897187 [PubMed - indexed for MEDLINE]


362:
Ginter E, Bilisics L, Cerven J.
Related Articles, Links

Cholesterol metabolism under conditions of acute and chronic vitamin C deficiency in guinea-pigs.
Physiol Bohemoslov. 1965;14(5):466-71. No abstract available.
PMID: 5862905 [PubMed - indexed for MEDLINE]


363:
GINTER E.
Related Articles, Links

[METHODICAL INFORMATION ON THE INDUCTION OF EXPERIMENTAL VITAMIN C DEFICIENCY IN GUINEA PIGS.]
Biologia (Bratisl). 1964;19:180-5. Czech. No abstract available.
PMID: 14135136 [PubMed - OLDMEDLINE for Pre1966]


364:
BOBEK P, GINTER E.
Related Articles, Links

[EFFECT OF C AVITAMINOSIS ON THE LEVEL OF SERUM LIPOPROTEINS IN GUINEA PIGS WITH INTACT AND TETRACHLORIDE-DAMAGED LIVERS.]
Cas Lek Cesk. 1963 Oct 4;102:1103-6. Czech. No abstract available.
PMID: 14052991 [PubMed - OLDMEDLINE for Pre1966]


365:
GINTER E.
Related Articles, Links

[GLYCOGEN SYNTHESIS IN VITAMIN C DEFICIENCY.]
Cesk Gastroenterol Vyz. 1963 Jul;17:310-3. Czech. No abstract available.
PMID: 14053037 [PubMed - OLDMEDLINE for Pre1966]


[Influence of carbon tetrachloride on the metabolism of 1-ascorbic acid.]
Cesk Hyg. 1962 Sep;8:453-60. Czech. No abstract available.
PMID: 13948049 [PubMed - OLDMEDLINE for Pre1966]


[Ascorbic acid and liver regeneration.]
Epatologia. 1962 Sep-Oct;8:410-26. Italian. No abstract available.
PMID: 13948045 [PubMed - OLDMEDLINE for Pre1966]


372:
BOBEK P, GINTER E.
Related Articles, Links

The dynamics of serum lipoprotein patterns in vitamin C-saturated and vitamin C-deficient guinea-pigs after carbon tetrachloride poisoning.
Experientia. 1962 Jun 15;18:267-8. No abstract available.
PMID: 13870289 [PubMed - OLDMEDLINE for Pre1966]


374:
GINTER E, CERVEN J.
Related Articles, Links

The effect of experimental C avitaminosis on the metabolism of nucleic acids.
Physiol Bohemoslov. 1962;11:529-34. No abstract available.
PMID: 13948048 [PubMed - OLDMEDLINE for Pre1966]


375:
GINTER E.
Related Articles, Links

The effect of scurvy on the metabolism of glutamine.
Physiol Bohemoslov. 1962;11:522-8. No abstract available.
PMID: 13948047 [PubMed - OLDMEDLINE for Pre1966]


376:
GINTER E.
Related Articles, Links

[Effect of vitamin C deficiency on the incorporation of S35-labelled methionine into tissue proteins in guinea pigs.]
Biologia (Bratisl). 1962;17:771-4. Czech. No abstract available.
PMID: 13948046 [PubMed - OLDMEDLINE for Pre1966]


377:
GINTER E.
Related Articles, Links

[Biochemical role of vitamin C in the process of wound healing. (Critical review of the literature)]
Lek Veda Zahr. 1960;8:169-74. Czech. No abstract available.
PMID: 13858657 [PubMed - OLDMEDLINE for Pre1966]


379:
DIBAK O, GINTER E.
Related Articles, Links

[Protective effect of food substances in fluorine poisoning.]
Vopr Pitan. 1959 Jul-Aug;18(4):3-11. Russian. No abstract available.
PMID: 13676441 [PubMed - OLDMEDLINE for Pre1966]


380:
GINTER E.
Related Articles, Links

[Avitaminosis C & the spectrum of free amino acids of skeletal muscle in the guinea pig.]
Cesk Gastroenterol Vyz. 1957 Sep 5;11(5):329-34. Czech. No abstract available.
PMID: 13547179 [PubMed - OLDMEDLINE for Pre1966]

If you made it this far, apparently all the work with guinea pigs produced an unexpected result. Some do in fact make their own vitamin C!

http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
Ascorbic acid synthesis in certain guinea pigs.

Ginter E.

Ginter wrote:
Three guinea pigs fed a vitamin C-free diet manifested no symptoms of scurvy even after 4-8 months, normally increased in body weight and excreted quantities of ascorbic acid in urine far exceeding the total body pool of ascorbic acid. The course of healing subsequent to experimental trauma in one of these animals proved to be entirely normal and vitamin C concentration in its liver after 8 months of a scorbutogenic regimen was found to be more than twice that in guinea pigs with a daily intake of 10 mg ascorbic acid. It is evident that certain guinea pigs are capable to synthesize ascorbic acid that fully covers the needs of the organism. However, the freqency of occurence of such guinea pigs appears to be extremely small.

_________________
Owen R. Fonorow, Orthomolecular Naturopath


Last edited by ofonorow on Wed Dec 28, 2005 6:12 pm, edited 1 time in total.

Tue Dec 27, 2005 10:40 pm
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Post Ginter: High Vitamin C Lows Elevated Cholesterol
Thank you. Wow!

_________________
Dolev


Wed Dec 28, 2005 12:51 am
Profile
Post Re: Ginter: High Vitamin C Lowers Elevated Cholesterol
ofonorow wrote:
If you made it this far, apparently all the work with guinea pigs produced an unexpected result. Some do in fact make their own vitamin C!

http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
Ascorbic acid synthesis in certain guinea pigs.

Ginter E.

Ginter wrote:
Three guinea pigs fed a vitamin C-free diet manifested no symptoms of scurvy even after 4-8 months, normally increased in body weight and excreted quantities of ascorbic acid in urine far exceeding the total body pool of ascorbic acid. The course of healing subsequent to experimental trauma in one of these animals proved to be entirely normal and vitamin C concentration in its liver after 8 months of a scorbutogenic regimen was found to be more than twice that in guinea pigs with a daily intake of 10 mg ascorbic acid. It is evident that certain guinea pigs are capable to synthesize ascorbic acid that fully covers the needs of the organism. However, the freqency of occurence of such guinea pigs appears to be extremely small.


Owen,

Wow! I wonder if some people also have that ability? It would go a long way to explaining the tremendous differences in "bowel tolerance" in people.

David


Tue Apr 04, 2006 9:38 am
Post Re: Ginter: High Vitamin C Lowers Elevated Cholesterol
:!: Bump :!:


Mon Aug 27, 2012 4:10 pm
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