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 Cyanide Pathway to ascorbic acid synthesis in humans 
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Vitamin C Expert
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Post Re: Cyanide Pathway to ascorbic acid synthesis in humans
Van Carman wrote:
I think what you are saying that this component being so available and cheap,couldn't be of any value.Thanks,Van


:?:

What I'm saying is pretty straightforward: you are making unsubstantiated and absurd claims.


Wed May 26, 2010 3:19 pm
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Ascorbate Wizard
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Post Re: Cyanide Pathway to ascorbic acid synthesis in humans
I think Ralph is correct, that there is no evidence of a cyanide pathway in vivo (in our bodies) but it turns out there is a cyanide pathway to synthetic vitamin C that was explored during the early efforts to find the best way to synthesize it.

I stumbled across the book VITAMIN C: Its Chemistry and Biochemistry by Michael B. Davies, John Austin, and David A. Partridge. On page 57,

Quote:
A third basic synthetic approach to L-ascorbic acid involves the combination of C(4) and C(2) carbon units. An example of this is the benzion condensation reaction between L-threose and ethyl glyoxalate in the presence of sodium cyanide.


Again, I don't see any relevance to reactions within our bodies, and the following is interesting:
Quote:
Other than D-glucose, only one C(6) precursor, D-galactouronic acid, obtained by enzymic hydrolysis of pectin, has been usefully converted into L-ascorbic acid but the overall yield is poor


And on a different topic, the books describes the chemistry of ascorbic acids first oxidation product - dehydroascorbic acid (DHA) (Which still has reduction properties). It is interesting that one of the several substances listed that recycle DHA back into AA is cysteine.
Quote:
The reduction back to ascorbic acid may also be accomplished by several different reagents, including hydrogen sulphide, hydriodic acid, cysteine and other thiols, and sodium dithionate.
...
The reaction of ascorbic acid with molecular oxygen is catalyzed by the copper containing enzyme ascorbic acid oxidase and the reduction of dehydroascorbic acid, most commonly by glutathione, by the enzyme DHA reductase.

[/quote]

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Thu May 27, 2010 4:39 am
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Post Re: Cyanide Pathway to ascorbic acid synthesis in humans
Yes! They are out there and they walk among us. < Quote from "The outer limits."


http://www.apricotsfromgod.info/index.html

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Thu May 27, 2010 4:57 am
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Ascorbate Wizard
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Post Re: Cyanide Pathway to ascorbic acid synthesis in humans
Quote:
What will happen to all of you when supplements are no longer available? Will you be aware of any alternate source for vitamin C besides fruits and vegetables?

I for one applaud Van's willingness to experiment and question the norm. It's pretty obvious that he's in the wrong forum to discuss anything out of the mainstream.


I've been thinking outside the box for 64 years.

What supports the notion that there is a cyanide pathway to ascorbic acid synthesis in humans?

Where are YOU going to get your supplements when they are no longer available?

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Last edited by Ralph Lotz on Sat May 29, 2010 6:30 am, edited 1 time in total.

Fri May 28, 2010 3:49 am
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Post Re: Cyanide Pathway to ascorbic acid synthesis in humans
Quote:
Does anyone on this group ever think outside the box?

Quote:
I've been thinking outside the box for 64 years.

If you acknowledge the box, your thinking is already constrained.


Fri May 28, 2010 3:35 pm
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Vitamin C Expert
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Post Re: Cyanide Pathway to ascorbic acid synthesis in humans
I am switching over to the apricot kernals.My thought is the bean lectins are much too toxic.Thanks and I hope this helps.Maybe 2 or 3 apricot kernals throughout each day should be enough.Van

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Thu Jul 15, 2010 5:10 am
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Post Re: Cyanide Pathway to ascorbic acid synthesis in humans
What's the current info on this? Looks like it slowed to a stop, been a while since a post!


Sat Aug 28, 2010 6:48 am
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Ascorbate Wizard
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Post Re: Cyanide Pathway to ascorbic acid synthesis in humans
Cyanide Pathway to ascorbic acid synthesis in a Pfizer plant
http://pubs.acs.org/doi/pdfplus/10.1021 ... 0200.ch001

"The intermediacy of the imino ether was proved by the isolation of 7 when D-glucosone was
treated w i t h potassium cyanide (16). The initial cyanohydrin adduct (3a) easily undergoes cyclization to the imino ether intermediate (aqueous solution for 10 m i n at room temperature, Scheme 5 ) ."

In order for this to work in humans, they would have to be at room temperature.

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Sat Aug 28, 2010 9:25 am
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Post Re: Cyanide Pathway to ascorbic acid synthesis in humans
I know very little about this laetrile stuff, but let me pose a question out of my ignorance. As I understand it, in cancer therapy, the laetrile is supposed to travel to the tumor cells where it releases the cyanide to kill the tumor cells. At least I think that is what is claimed.

If something like this occurs, is it plausible that laetrile provides a vitamin C sparing service so that in people with high vitamin C demand, it may appear as if it were synthesized???

I cannot grasp the synthesis idea, but some vitamin C sparing activity seems plausible.


Sat Aug 28, 2010 11:03 am
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Post Re: Cyanide Pathway to ascorbic acid synthesis in humans
Every molecule runs a gamut from electron donating to electron accepting depending on their relative electro negativity.

Any number of molecules spar vitamin C.


Sat Aug 28, 2010 2:28 pm
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Post Re: Cyanide Pathway to ascorbic acid synthesis in humans
I think this thread should continue.The benefits of Vitamin B17 are very apparent.Look what it does for the Hunza people.Thanks,Van

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Mon Nov 01, 2010 9:48 am
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Post Re: Cyanide Pathway to ascorbic acid synthesis in humans
Van what happened to you using olive leaf to repair your GLO?


Wed Nov 03, 2010 12:58 am
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Post Re: Cyanide Pathway to ascorbic acid synthesis in humans
Quote:
If you acknowledge the box, your thinking is already constrained.


Keep an open mind, but never so much that your brain falls out.


Wed Nov 03, 2010 1:00 am
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Post Re: Cyanide Pathway to ascorbic acid synthesis in humans
The olive leaf if nothing else is vitamin C sparing.Being powerfully antioxidant it allows vitamin C to do its over 3000 other jobs in our body.By the way olive leaf has trace amounts of cyanide.Thanks,Van

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Thu Dec 16, 2010 1:42 pm
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Post Re: Cyanide Pathway to ascorbic acid synthesis in humans
I have been bothered with gastric runaway(bloating and flatulence).Nothing gave much relief so in desperation I tried one apricot kernal.I seconds I felt relief.How long this effect lasts I don't know but I plan to have more kernals available when needed.Try this to see if it works for you.Thanks,Van

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Thu Jan 13, 2011 1:38 pm
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