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majkinetor wrote:The most known interaction is with aspirin (easily prevented by not taking them together). Synergic effect may cause an increased bleeding in the digestive tract. Aspirin is one of the drugs that is for instance regularly prescribed to prevent heart attacks, strokes, and blood clot formation. This is especially important since Pauling Therapy may be used in parallel with allophatic therapy for CVD witch might include Aspirin.
Vitamin C may also reverse anticoagulant activity of warfarin.
Vitamin C, Its Chemistry and Biochemistry, Page 89.
"A significant role is played by oxidizing enzymes associated with the microsomal fraction, notably a cytochrome called P450 which is a mixed function oxidase (MFO). This very broad-specificity enzyme, which helps dispose of ethanol, benzene, tetracholromethane, and polychlroinated biphenyls (PCBs) to name but four notorious toxins, may depend for its action on the presence of vitamin C since...."
Owen wrote:As far as the idea that vitamin C can counteract the anticoagulant activity of rat poison (warfarin) I would appreciate a reference.
Walfarin and Related Oral Vitamin K Antagonist Antikoogulants
From "Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies by Mitchell Bebel Stargrove ND". Data from some, but not all, animal experiments and rare, unqualified case reports indicates that vitamin C, in high doses, might decrease functional level and therapeutic acdtivity of warfarin, but the cumulative body of evidence fails to support a well-founded, consistent, and generalizable conclusion.
Findings from the four controlled trials involving large number of subjects indicate a lack of clinically significant interaction between warfarin and ascorbic acid, event at doses as high as 10g vitamin C per day.
Read...
Owen wrote:I know that Irwin Stone and others cited research to the contrary, that because of the risk of bleeding, all doctors should recommend vitamin C be taken with aspirin as a matter of course.
Owen wrote:So the answer to the question is that although we cannot prove a negative, taking vitamin C along with a drug is generally favorable, with few or no known contraindications.
Findings from the four controlled trials involving large number of subjects indicate a lack of clinically significant interaction between warfarin and ascorbic acid, event at doses as high as 10g vitamin C per day.
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