On the other hand, maybe your genetics require sugar for functioning more then for other people and megadoses of C prevent sugar from entering the body.
Interesting twist, but I know of little or no scientific support for this speculation.
majkinetor wrote:Interesting twist, but I know of little or no scientific support for this speculation.
Thats not speculation. Glucose and DHAA compete, so the more DHAA you have in the gut, the less glucose can enter.
)At high dietary doses (corresponding to several hundred mg/day in humans) ascorbate is accumulated in the body until the plasma levels reach the renal resorption threshold, which is about 1.5 mg/dL in men and 1.3 mg/dL in women. Concentrations in the plasma larger than this value (thought to represent body saturation) are rapidly excreted in the urine with a half-life of about 30 minutes; concentrations less than this threshold amount are actively retained by the kidneys, and half-life for the remainder of the vitamin C store in the body increases greatly, with the half-life lengthening as the body stores are depleted.
Ascorbic acid (AA) is oxidized to dehydroascorbic acid (DHAA) when utilized in vivo. This metabolite is then rapidly taken up by blood cells or other tissues and reduced back to AA
by a glutathione and/or NADPH-dependent DHAA reductase ( I ). This cycle serves to save DHAA from rapid hydrolysis to diketogulonate, which cannot be recycled to AA and supplies AA for cellular metabolism. Hence, impaired cellular uptake of DHAA would accelerate vitamin C depletion. Cellular uptake of DHAA shares a common transport system with glucose, and, in vitro, glucose inhibits cellular transport of vitamin C in a dose dependent
The claim is hard to accept, (or at least for me to understand) because it implies that the only way vitamin C can enter cells is to become oxidized (AA) or when it is in the form of sodium ascorbate (via the the sodium transporters, but in this case, SA shouldn't compete with glucose?)
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