Dr.Levy points out Lipo c is intracellular, while AA is extracellular and he recommends using AA along with your lipo.

Liposome-encapsulated vitamin C has the convenience of an oral administration while offering a bioavailability technically superior even to C delivered by vein. In other words, an intravenous result delivered by mouth is now possible.

Once a month, or even once a week, take spaced doses of vitamin C powder dissolved in water until the onset of diarrhea. At this point a baseline dose can be determined, and the bowels will benefit from a healthy cleanse.
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When the baseline requirement is established, supplementation on subsequent days could include a combination of a liposomal formulation and sodium ascorbate powder or either type alone.

It seems to me that we are not even sure that the vitamin c from the liposomes is available in the blood stream.

The similarity in the plasma response curves for liposomal vitamin C and the standard commercial formulation, shown in Figure 1 (5g doses), is interesting. There is a hint that the liposomal form has a slower onset to peak level and a broader profile. Liposomes are absorbed from the gut and into the liver, before being released into the blood stream. This response can be seen more clearly in the 20g dose, in Figure 2. It is apparent that sustained levels of plasma ascorbate, above the previously assumed maximum of 220 μM/L, are possible with oral intakes of liposomal vitamin C.

Ah, if you're basing it on an experimental result, cool. For a minute I thought you were basing it only on general microbiology theory.

But even more importantly, the evidence is now showing that you just don’t get absorbed into the blood and release it into the blood.
It gets absorbed into the blood, and then in the same mechanism it gets absorbed into the blood, it will pass directly into the cell so that
you get it from taking something orally, you get an intracellular delivery.

but as ascorbate or is it still incapsulated as a liposome.That is the question.

as ascorbate.

Hello Justin,

Thanks for your note.

When the lypo C is in the blood, before being taken up by any cells, it will still register as vitamin C on a blood level test of vitamin C, even though it is encapsulated in liposomes and not just present in the plasma by itself. So, equivalent amounts of liposome encapsulated vitamin C have superior absorption into the plasma, and from there, they have superior take-up inside cells. Some of the C is directly released into the cytoplasm, and some of the liposomes are still intact inside the cytoplasm, at least for a while.

Hope this clarifies things,

Dr. Levy