Moderator: ofonorow
Disclaimer: For forum readers who now consider me a hypocrite for citing studies, I have two things to say. First, I have met Dr. Pincus, and he is interested in the truth. Second, I noted posting these links that many are missing even the abstract in pubmed!!
Norman M. Brown wrote:Alpha Lipoic Acid is not patentable, and low dose Naltrexone (used for the pancreatic cancer treatments) has been off patent (generic) since 1984, 2 years after Ian Zagon discovered its potential for cancer treatment.
gofanu and jaamzg wrote:Wise words about B vitamins.
What I found interesting about your situation is that the adrenal glads started working again, which you said is not supposed to happen. Now, I have no knowledge about adrenal glands or anything of the such, it just doesn't make a lot of sense to me, especially, if 90% of the gland had to be gone for you to experience those symptoms.
As Jefferies research found, influenza attacks the pituitary, effectively turning of ACTH. (I have a feeling
that something like this happened during all the infections.)
However, a lack of or inability to produce CRH can also lead to low cortisol.
Finally, there are "receptor" issues where these hormones lose their ability to control cortisol.
Much evidence supports the concept that vitamin C has an inhibitory effect on steroid production in vitro in experimental animals (for reviews, see refs. 1 and 2). However, except for one study on the role of vitamin C in adrenal steroids in children,' the role of this vitamin in adrenal steroid production in humans is lacking. Therefore, the purposes of the present study were to investigate whether consumption of megadose vitamin C for a short period affects the adrenal glucocorticoid and androgen levels of adult men and to locate the possible site(s) of blockage of the steroidogenesis pathway.
- Influenza destroying pituitary with 18g/day vitamin C for decade ? Mhmm...
- Since ACTH is created by orders of CRH, testing ACTH determines the validity of both hypothesis. CRH is also anorectic hormon, lack of which may be involved in wieght gain.
- Corticosteroid resistance ? That would be more visible via other sympthoms I guess. Since cortisol regulates hypoglicemia apart from glucagon, I guess sugar metter after exercise or ketogenic diet could be used as a test.
- Pituitary lessions would probably influence CoQ10 levels, might be good to check them out or supplement megadoses (>300mg or something...). See "Coenzyme Q10 evaluation in pituitary-adrenal axis disease" in which they say that hipoadrenalism is related to low CoQ10 levels.
- Another possible reason is lack of cholesterol. Check this out. Since cholesterol synthesis was a problem bellow, ACTH was very high - http://goo.gl/06PLl
- Finally, maybe vitamin C megadose is responsible,Vit C effects on adrenal gland are not yet well understood. But here is one interesting study "Bimodal Effects of Megadose Vitamin C on Adrenal Steroid Production in Man", using 4g/day vit C dose:
Owen wrote:And? What were the results of the study?
Although ingestion of vitamin C did not alter the normal pattern of diurnal variation of plasma cortisol levels, it significantly lowered mean plasma cortisol levels at O400, 0800, 1600, and 2000 hours (p < 0.05). Moreover, a significant decrease in the overall 24-hour plasma cortisol curve during vitamin C ingestion compared to the control period was observed (p < 0.02).
Our studies indicate that megadose vitamin C decreases the sensitivity but not the capacity of adrenal gland to respond to ACTH. The present findings are in support of our earlier work in vitro, in that vitamin C in beef adrenal inhibited 21-hydroxylase' and shifted the ACTH dose-response curve of corticosterone in rat adrenal to the right. It is tempting to postulate that with vitamin C ingestion there may be a partial blockage of 2 1 -hydroxylase so that more substrate becomes available for the androgenic pathway. This blockage is incomplete since a higher ACTH dose reverses the abnormal cortisol response to the low dose.
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