Is Vitamin C a Miracle Cancer Cure?
Yes and no. Non-toxic "chemo" is the miraculous promise of "vitamin C" in the fight against cancer.
Recently, exciting research has been published that documents the ability of vitamins C, E and selenium orally to prevent most cancers, and to decrease the mortality of pancreatic cancers, stomach cancers, prostate cancers and other cancers. It sounds too good to be true. The Vitamin C Foundation is interested in the how and why vitamin C prevents and treats cancers.
Almost all vitamin C experts agree, hydrogen peroxide produced by high levels of ascorbate (vitamin C) kill cancer cells.
However, vitamin C by itself is relatively weak at this job so don't try low dosages. Experts recommend continuous high dosages of ascorbate (vitamin C) combined with specific adjuncts (e.g. Alpha Lipoic Acid, Vitamin K3, and/or D'Fraction Maitake Mushroom.)
Most experts recommend incorporating high-dose intravenous vitamin C (IV/C) infusions to achieve the high blood concentrations necessary to kill the most tumor cells.
Expert Opinion: The Case for Vitamin C Against Cancers
Talking to your Oncologist
You may be able to talk your oncologist into going along with vitamin C as an 'adjunct' (not a replacement for) conventional chemotherapy.
Cancers have increased insulin receptors and thrive on sugar. All carbohydrates reduce to simple sugars during digestion. This is why low-carb, low-sugar (ketogenic) diets can be important to starve fast growing tumors of glucose.
Glucose, a component of most sugars, competes with vitamin C for entry into cells because these molecules are similar. This may be why the low-carb diet enhances vitamin C anti-cancer therapies.
Good Advice: Take Oral Vitamin C Too - All Day
Authors Hickey and Roberts stress that vitamin C should be taken orally 24/7 to keep the oxygen "redox" pressure on cancer tumors (i.e. not only during regular intravenous vitamin C infusions.)
Handbook on Vitamin C Therapy for Patients and Doctors by Steve Hickey and Hilary Roberts
The new Vitamin C Foundation sugar-free chewables (with Niacin) help with compliance, i.e. one tasty tablet every 3 to 4 hours, and they may help reduce the sugar/carb craving.
Cameron's chewables also contain important ingredients that may have contributed to the outstanding Pauling/Cameron results in their Scottish study. Visit this forum topic on how and why new Vitamin C Foundation approved chewable vitamin C may contain Ewan Cameron's Secret Weapon against cancer.
There must be a downside? Linus Pauling and Ewan Cameron warned that it is prudent to start vitamin C therapy slowly in advanced cancers, otherwise the massive tumor die-off may kill the patient.
Rationale for Intravenous Vitamin C in Cancer Patients
Research that began Hugh Riordan's clinic has demonstrated that several substances can be taken with vitamin C to enhance the "cancer killing" effect. These are Alpha-Lipoic Acid, Vitamin K3, and recently, D'Fraction Maitake Mushroom Extract.
For best results, IV/C combined with continuous oral vitamin C 24/7.
High and continuous dosing of vitamin C is key. Experts Steve Hickey and Hilary Roberts tell us in their landmark book CANCER: NUTRITION AND SURVIVAL, that oral vitamin C by itself is a relatively weak cancer fighter, and, if given infrequently, might even feed certain tumors.
Thomas Levy MD, JD: Vitamin C and Cancer
Often a combination of one or more of the following is used: surgery, radiation, and chemotherapy. The theory behind radiation and chemotherapy is that the more rapidly growing cancer cells are less able to defend themselves from toxic assault than the normal cells. Radiation and nearly all chemotherapy drugs are themselves carcinogenic (cancer-causing), since they increase oxidative stress in all the cells treated, not just cancer cells.
High-Dose Vitamin C Approach:
Case studies demonstrate success in treating and even completely resolving various cancers with high-dose vitamin C.
In advanced cancer patients, high-dose vitamin C therapy compared to conventional therapy at one facility over a 3-year period shows:
- 75% better breast cancer survivor rate
- 867% better long cancer survivor rate
- 107% better colorectal cancer survivor rate
When breast cancer patients made this facility as their first treatment option, the 3-year survival rate improved by 134%.
High-dose vitamin C enhances the effectiveness of traditional chemotherapies.
Vitamin C has its own cancer cell-killing ability, and it also significantly improves the cell-killing ability of doxorubicin - even when the vitamin C is given at a non-cytotoxic dosage, it still improves the cell-killing ability of doxorubicin.
-- Thomas Levy, MD
Author and Vitamin C Expert Dr. Thomas E Levy, MD,JD, wrote to us:Hi Owen,
I am a fan of IVC, always have been. However, vitamin C that is legitimately encapsulated in liposomes, as I have used from LivOn Labs for many years now, also has a profound impact on cancer. Anecdotally, I have seen many cancers now respond dramatically and/or completely resolve with IVC, sodium ascorbate powder chronically pushed to bowel tolerance, and relatively low dose of liposome-encapsulated vitamin C (3 to 6 grams/packets daily). All these forms of vitamin C as monotherapy have achieved these dramatic results. That said, the more forms you take of vitamin C, in the highest tolerable/affordable doses, the better.
While there are many positive things vitamin C can do to help resolve a cancer by its concentration in the extracellular space, I do not believe the evidence supports this as being the primary site of cancer resolution. Anything that causes apoptosis and/or necrosis of a cancer cell does so by ramping up intracellular oxidative stress to the point that is incompatible with continued cell life. If that point is reached relatively gradually, apoptosis, or programmed cell death occurs. If that intracellular oxidative stress escalates rapidly, it results in frank necrosis and cancer cell rupture.
Probably the most common, and perhaps the only significant way a cancer cell can reach a fatal level of increased intracellular oxidative stress from vitamin C, is via upregulation of the Fenton reaction inside the cell. The Fenton reaction involves this sequence: VC converts ferric to ferrous. Ferrous gives its electron to hydrogen peroxide, and the devastatingly destructive free radical, hydroxyl radical, is produced.
The cancer cell is especially susceptible because its accumulates iron, and it is deficient in catalase, increasing peroxide levels. The Fenton reaction is just "waiting" to be stimulated in such a cell. Furthermore, the liposome delivery system is, far and away, the best way to elevate vitamin C inside the cells of the body, including cancer cells.
When the elevated intracellular oxidative stress is downregulated in a cancer cell, such as by removing calcium from the cytoplasm, the cell becomes less malignant and will be less prone to metastasize and proliferate. It is the modulation of the intracellular oxidative stress that allows malignant transformation in the first place, and that can prevent it from taking place as well. The abnormalities in the extracellular space, in my opinion, make a lesser contribution to the malignant state and its maintenance versus the microenvironment inside the cancer cells.
On my website, peakenergy.com, I have written multiple articles addressing why tracking blood levels of liposome-encapsulated vitamin C is absolutely irrelevant in ascertaining its clinical impact, why the Multi-C Protocol is the way to go, and why liposomes supercharge critical immune cells with vitamin C, in addition to elevating its levels inside the cells of the body, including any cancer cells that are present.
I hope this helps clarify things for the forum participants. At the risk of being accused of trying to make a buck, I covered all of this in even greater detail in my new book, Death by Calcium.
Make Vitamin C More Powerful Against Cancers
Vitamin C's anti-tumor and cancer killing effect can be enhanced by supplementing at least one of the following three nutritional supplements:
Alpha Lipoic Acid (orally 600 mg daily in two equal dosages)
Maitake Mushroom D'Fraction
Induction of Cell Death in Renal Cell Carcinoma With Combination of D-Fraction and Vitamin C. Conclusion: The present study demonstrates that the combination of D'Fraction and Vitamin C can become highly cytotoxic, inducing severe cell death in ACHN cells.
For Immediate Release
Conclusions: The present study demonstrates that the efficacy of chemotherapeutic drugs can be improved with PDF to a certain extent, but the mushroom extract-D Fraction/Vitamin C combination can lead to severe apoptotic cell death with a G1 arrest and the modulation of critical apoptotic regulators. Thus, these findings suggest that PDF may have a great potential as an adjuvant agent that can be combined with chemotherapeutic drugs or with Vitamin C for the improved treatment of various urological malignancies."
Controversy: Does Vitamin C Work Inside or Just Outside of Cancer Cells?
Another camp believes that the oxygen redox levels inside cells (from massive amounts of ascorbate entering cancer cells) is what causes cancer cell death from apoptosis (cell suicide). This camp recommends intravenous vitamin C, but also recommends keeping the pressure on tumor cells with oral vitamin C to tolerance all day long.
Ralph Moss: Antioxidants Increase Chemo Potency Against Cancer
The following tables from the Moss book illustrate that vitamin C the effectiveness of using vitamin C (and vitamin E) as an adjunct to conventional therapies.
|Agent Used||Decrease in Cancer Growth|
|5-FU + Vitamin C||95.5%|
|X rays + Vitamin C||98.2%|
|Bleomycin + Vitamin C||92.0%|
|Agent Used||Decrease in Cancer Growth|
|Bleomycin + Vitamin E||71%|
|5-FU + Vitamin E||71%|
|Adriamycin + Vitamin E||88%|
|Cisplatin + Vitamin E||82%|
Source: Kedar Prasad, University of Colorado, as summarized in Antioxidants Against Cancer by Ralph Moss
Case: Vitamin C Topically Cures Basal Carcinoma (Skin Cancer)
I had done this to two of them on my face recently. I used ascorbic acid and she used buffered c from life extension which is just like c-salts from nutri.com. I had read about and visited Dr. Riordan in Wichita, KN. and knew of the cytotoxicity of ascorbate to many cancers in vitro. I figured why not put it directly on a basal cell and see what happens.
It is nothing short of miraculous!
Pass this information on and watch the dermatology industry react.
W. W., MD
Review of the Recent Science
The study led by S.Y. Pan of Public Health Agency of Canada, Ottawa, Ontario, Canada and colleagues showed that premenopausal women who had taken zinc supplements for 10 years or longer were 54 percent less likely to develop breast cancer, compared to those who had not.
The study also showed that supplementation of multivitamin, beta-carotene, vitamin C, vitamin E and zinc for 10 or more years was associated with 26, 42, 21, 25, and 53 percent reduced risk of breast cancer , respectively, in postmenopausal women.
On the other hand, dietary antioxidants including beta-carotene, alpha-carotene, lycopene, lutein and zeaxanthin, vitamin C, vitamin E, selenium and zinc or supplementation of antioxidants for less than 10 years were not associated with reduced risk of developing breast cancer.
"This is the first time the effect of combining retinoic and ascorbic acid on breast cancer cell proliferation, differentiation, apoptosis and antioxidant-related gene expression has been studied."
The Journal of Nutritional Biochemistry
Volume 17, Issue 7, July 2006, Pages 454.462
Retinoic acid and ascorbic acid act synergistically in inhibiting human
breast cancer cell proliferation
Corresponding author contact information, E-mail the corresponding author.
- ABSTRACT: Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues...
- Growth suppression of malignant leukemia cell line in vitro by ascorbic acid (vitamin C) and its derivatives
- Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro
- Higher plasma vitamin C levels decrease risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition ...
- Research backs theory that vitamin C shrinks tumors...
Cancer: Intravenous Vitamin C Effective Treatment
"The United States National Institutes of Health researchers found ascorbate killed cancer cells at concentrations that would only be achievable through intravenous infusion. Normal cells were not affected by ascorbate at any concentration. [More sepp commentary]"
- Intravenously administered vitamin C as cancer therapy: three cases...
- Annals of Internal Medicine: Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use ...
- Intravenous Ascorbate as a Tumor Cytotoxic Chemotherapeutic Agent...
- Vitamin C protects against melanoma skin cancers
- Inhibition of liver cancer cell proliferation and migration with ascorbic acid (vitamin C)...
Large study finds vitamin C protective of stomach cancer...
But when the researchers examined the blood levels of vitamin C they found a strong protective effect. That is: they found that those subjects with the highest level of vitamin C in their blood had a 60 percent lower risk of stomach cancer than those subjects with the lowest levels.
- Vitamin C and Stomach Cancer...
- Low vitamin C linked to stomach cancer...
- Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues ...
- Ascorbic Acid (Vitamin C) Kills Cancer Cells...
- Colds "may trigger child cancers" ...
- High antioxidant vitamin intakes reduce adverse effects of chemotherapy in children with acute lymphoblastic leukemia...
- Inhibition of liver cancer cell proliferation and migration with ascorbic acid (vitamin C)...
- Combination therapy with vitamins C plus E inhibits human prostate cancer cell growth...
- In vivo antitumor effect of ascorbic acid, lysine, proline and green tea extract on human prostate cancer ...
- Autoschizis: How vitamins C and K3 kill cancer cells...
- More on vitamin induced autoschizis for prostate cancer...
- Orthomolecular oncology review: ascorbic acid and cancer 25 years later...
Preparation of Sodium Ascorbate for IV and IM Use... Cathcart's Written Instructions for Physicians
Animal-Based Nutrients Linked With Higher Risk Of Stomach And Esophageal Cancers Vitamin C supplements reduce stomach cancer by 40% Yale researchers also found that regular users of vitamin C supplements were at significantly lower risk of stomach cancer.
Vitamin C and Vitamin K3 cause massive cancer cell death. From Science News.
Vitamin C Foundation comments: Are high antioxidant intakes bad for your health?
Final Report of the Safety Assessment of [Vitamin C] i.e., L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as Used in Cosmetics...
Foundation Does Not Sell Vitamin C
Quali-C® is a registered trademark of DSM Nutritional Products.
True-Liposomes™ is a trademark of The Vitamin C Foundation.
China-FREE™ is a trademark of Inteligent*Vitamin*C Inc.
"We have had the opportunity to observe patients who have taken 10g or more per day of vitamin C during intense chemotherapy. We now recommend a high intake of vitamin C, in some cases up to the bowel-tolerance limit, beginning as early as possible." Linus Pauling (Pg. 241, HOW TO LIVE LONGER AND FEEL BETTER, 1986, paperback)
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