Herein he describes the normal life-history of an unchecked cancerous growth—the growth goes on its own course merrily, without restraint from the enzyme treatment exhibited.*
“In the last four years a fair amount of pathological evidence has been acquired, which is not in accordance with Dr. Bainbridge’s experience; and, without going minutely into details, ‘let me cite two cases which seem to me to indicate (i) that trypsin does attack cancerous growths; (2) that trypsin can destroy cancerous growths
“CASE 1.—Male, 51. Lympho—sarcoma. Superficial cervical glands. Died from haemorrhage from separating sloughing tumour. Naked-eye inspection of the tumour showed no gland-tissue whatever, it was a dense fibrous stroma pent up with purulent fluid. Microscopically, all that remained of the malignant cells were keratinous masses, in which the individual cells were unrecognizable. The treatment had exerted a selective action on the malignant cells, had destroyed them almost entirely, and their necrotic remains were in process of removal by leucocytes.
“CASE 2.—Male, 25. Round-celled sarcoma of upper jaw. Primary growth removed by operation . . . recurrence in all the glands of the left side of the face. Treatment begun March 8, 1909. Tumour removed entire as one large slough on July 15, 1909, patient making an excellent recovery.
“What happened in both these cases was that under the action of trypsin the tumour became gangrenous.
* If account be taken of the “heterolytic” cancer-ferment termed by me” malignin,” and of the antitryptic properties of the blood in most, if not all, cancer cases, it must be clear that Dr. Bainbridge produces no evidence at all that he has ever had free pancreatic ferments in the blood of any of his unsuccessful cases. Nay, in view of Captain Lambelle’s apt criticism concerning the natural course of cancer, described by Dr. Bainbridge in his report, it is quite palpable that Dr. Bainbridge, in any of these unsuccessful cases, had never exhibited sufficient trypsin and amylopsin to neutralize the cancer ferment or ferments present.