Vitamin C Foundation Content Last Updated: Sun Jul 16 13:36:02 GMT+4 2017

VITAMIN C SCIENCE
REVIEW

"Vitamin C is the only vitamin repeatedly proven to increase the human lifespan when taken in doses that exceed dietary levels of this vitamin." - Bill Sardi

Interview with Dr. Kalokerinos. Strong Argument Against Vaccinations

"Dr. Kalokerinos thought differently. He pinpointed the increase in vaccination campaigns as the reason why, at a certain point, up to half of the vaccinated Aboriginal infants died, obviously from an acute vitamin C deficiency provoked by the vaccination."

"Megadose" Vitamin C Cuts Cold Symptoms 85%

The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections.

Gorton HC, Jarvis K.

BACKGROUND: An ever increasing demand to evaluate the effect of dietary supplements on specific health conditions by use of a "significant scientific" standard has prompted the publication of this study. OBJECTIVE: To study the effect of megadose Vitamin C in preventing and relieving cold and flu symptoms in a test group compared with a control group.

DESIGN: Prospective, controlled study of students in a technical training facility.

SUBJECTS: A total of 463 students ranging in age from 18 to 32 years made up the control group. A total of 252 students ranging in age from 18 to 30 years made up the experimental or test group. METHOD: Investigators tracked the number of reports of cold and flu symptoms among the 1991 test population of the facility compared with the reports of like symptoms among the 1990 control population. Those in the control population reporting symptoms were treated with pain relievers and decongestants, whereas those in the test population reporting symptoms were treated with hourly doses of 1000 mg of Vitamin C for the first 6 hours and then 3 times daily thereafter. Those not reporting symptoms in the test group were also administered 1000-mg doses 3 times daily.

RESULTS: Overall, reported flu and cold symptoms in the test group decreased 85% compared with the control group after the administration of megadose Vitamin C.

CONCLUSION: Vitamin C in megadoses administered before or after the appearance of cold and flu symptoms relieved and prevented the symptoms in the test population compared with the control group.

J Manipulative Physical Ther 1999 Oct;22(8):530-3 Found in

Designs for Health Weekly
12/17/01 - Number 9
By Jonathan Lizotte
Editor, Designs for Health Weekly jonathan@dfhi.com
http://www.designsforhealth.com
http://www.dfhi.com http://www.findanutritionist.com


Proton pump inhibitors (i.e. Nexium® and Prilosec®) reduce the bioavailability of dietary vitamin C

We have shown that a short course of omeprazole will cause a reduction in the plasma vitamin C level of healthy volunteers. This decrease in plasma vitamin C is independent of dietary intake of the vitamin and indicates reduced bioavailability. The clinical significance of this is unclear but any adverse effects will be most apparent in H. pylori infected subjects who have a low pre-treatment vitamin C status.
Unnaturally low stomach acid (elevated pH) is hurts health in several ways.. Low stoach acid leads to infection upper tract infections, because intestinal flora find it easier to travel up the gut to the lungs. Acid blocking drugs also block vitamin C at the same time, which hampers the immune system.

Vitamins C & E Cut ICU Deaths in Half...

The early administration of antioxidant supplementation using alpha-tocopherol and ascorbic acid reduces the incidence of organ failure and shortens ICU length of stay in this cohort of critically ill surgical patients.

The New Standard of ER Medical Care

When Dr. Thomas E. Levy, MD, JD wrote the book Primal Panacea in 2011, he informed us..

"that not a single hospital in the United States utilized Intravenous Vitamin C."

The Cure for Sepsis - Vitamin C

After Dr. Marik's Vitamin C Cures Sepsis discovery was shown on television it created a new standard of medical care. According to Dr. Levy,

"" The Vitamin C genie is now out of the bottle since the mainstream press inadvertently gave this publicity. Any patient can demand Vitamin C now, or tell the doctor/hospital to face the legal consequences. “It’s all a question of when critical mass is reached, and I think the TV report pushed the issue to that point… ” – Dr. Thomas E. Levy. MD, JD

HARVARD: "Vitamin C 'ONLY SUBSTANCE OUT OF 880 TESTED' That Transforms Mouse Stem Cells into Heart Muscle Cells

Richard T. Lee, M.D., senior author of the study, says: "We have been taught for decades that when your heart cells are dead, they are dead and there is nothing we can do about it. We are excited about anything suggesting that we can grow more heart cells."

Lee and his colleagues tested 880 bioactive substances – including drugs and vitamins – approved by the U.S. Food and Drug Administration (FDA) to see if they stimulated the mouse stem cells to become heart muscle cells. The cells were genetically altered to give off a fluorescent bright green color when viewed under a microscrope if they had become heart muscle cells.

"We only got 1 out of the 880 to light up, and that was from ascorbic acid, the chemical commonly known as vitamin C," says Lee, an associate professor of medicine at Harvard Medical School and Brigham and Women's Hospital in Boston, and a lecturer in biological engineering at the Massachusetts Institute of Technology in Cambridge, Mass.

HARVARD: "VITAMIN C 'ONLY SUBSTANCE OUT OF 880 TESTED' THAT TRANSFORMS MOUSE STEM CELLS INTO HEART MUSCLE CELLS"...

16-Year Harvard Study Finds Single Vitamin C Pill Would Save 300,000 Lives Annually...

"The study published July 16, 2003 in CARDIOLOGY tracked more than 85,000 nurses over 16 years found that those taking vitamin C supplements (360 mg) had almost 30 percent lower risk of getting heart disease. The number of deaths from heart disease every year is estimated at 950,000.

Interestingly, dietary intake of vitamin C seemed to have little effect on coronary heart disease risk. But if women used vitamin C supplements, their risk was reduced by 27 percent."

16-Year Harvard Study Finds Single Vitamin C Pill Would Save 300,000 Lives Annually...

John Hopkins:Combining vitamin E and vitamin C supplements can dramatically reduce the risk of Alzheimer's

Peter P. Zandi, PhD, lead author of the study and an assistant professor in the School’s Department of Mental Health, said, “These results are extremely exciting. Our study suggests that the regular use of vitamin E in nutritional supplement doses, especially in combination with vitamin C, may reduce the risk of developing Alzheimer's disease.”

The researchers examined data from the Cache County Study, which is a large, population-based investigation of the prevalence and incidence of Alzheimer’s disease and other dementias. Residents who were 65 or older were assessed from 1996-1997 and again from 1998-2000 Vitamin Supplement Use May Reduce Effects of Alzheimer’s Disease

Vitamin C consumption not associated with risk of kidney stones.

Intake of vitamins B6 and C and the risk of kidney stones in women

Curhan, G. C., Willett, W. C., Speizer, F. E., Stampfer, M. J.

J Am Soc Nephrol 10:4:840-845, Apr 1999

Abstract

Urinary oxalate is an important determinant of calcium oxalate kidney stone formation. High doses of vitamin B6 may decrease oxalate production, whereas vitamin C can be metabolized to oxalate. This study was conducted to examine the association between the intakes of vitamins B6 and C and risk of kidney stone formation in women. The relation between the intake of vitamins B6 and C and the risk of symptomatic kidney stones were prospectively studied in a cohort of 85,557 women with no history of kidney stones. Semiquantitative food-frequency questionnaires were used to assess vitamin consumption from both foods and supplements. A total of 1078 incident cases of kidney stones was documented during the 14-yr follow-up period. A high intake of vitamin B6 was inversely associated with risk of stone formation. After adjusting for other dietary factors, the relative risk of incident stone formation for women in the highest category of B6 intake (> or =40 mg/d) compared with the lowest category (<3 mg/d) was 0.66 (95% confidence interval, 0.44 to 0.98).

In contrast, vitamin C intake was not associated with risk. The multivariate relative risk for women in the highest category of vitamin C intake (> or =1500 mg/d) compared with the lowest category (<250 mg/d) was 1.06 (95% confidence interval, 0.69 to 1.64). Large doses of vitamin B6 may reduce the risk of kidney stone formation in women. Routine restriction of vitamin C to prevent stone formation appears unwarranted.

Linus Pauling was a mentor of mine and a sponsor of the Center for Vitamins and Cancer Research that I co-founded at the University of Colorado Medical School in 1980. He was a great supporter of Vitamin C for all that ails you. There are many recent research papers showing reduction in heart disease, increased longevity, and so forth from taking more than 10 times the government recommended amount of Vitamin C. One of the arguments against taking large amount of Vitamin C was the risk of kidney stones. That debate has been laid to rest by a large study showing no increase in kidney stones from Vitamin C and a significant reduction in kidney stones from increased Vitamin B6.

posted by Jeff Sutherland @ 8:45 AM

Submitted by Chris Gupta


Two Mortality Studies on Danger of Low Vitamin C Blood Levels

Cambridge Medical School Researchers report: Even Minuscule increases in Blood Vitamin C Levels Result in Great Decreases in Death from All Conditions (Why didn't this peer-review, published report make world-wide news?)

British researchers report in the March 3, 2001 issue of Lancet that even minuscule increases in blood vitamin C levels, corresponding to consuming an extra 50 mg of fruite (1/2 apple or orange), can produce a 20% decrease in the risk of death from all conditions. Dr. Kay-Tee Khaw and his colleagues at the University of Cambridge School of medicine studied 19,500 men and women ages 45-79 and related their blood vitamin C levels to the risk of death from cardiovascular disease, heart attacks, and prostate cancer (for men only), as well as to the overall risk of death within a specific time period. Individuals with the highest blood vitamin C levels had only about half the risk of death within a specific time period that those with the lowest levels had.

Found in the Journal of Longevity, Hans Kugler, PhD, Vol 7/No. 4


Purpose: To examine the relation between serum ascorbic acid (SAA), a marker for dietary intake (including supplements), and cause-specific mortality.

Subjects and Methods: We analyzed data from a probability sample of 8,453 Americans age 30 years at baseline enrolled in the Second National Health and Nutrition Examination Survey (NHANES II), who were followed for mortality endpoints. We calculated relative hazard ratios as measures of disease association comparing the mortality rates in three biologically relevant SAA categories.

Results: Participants with normal to high SAA levels had a marginally significant 21% to 25% decreased risk of fatal cardiovascular disease (CVD) (p for trend = 0.09) and a 25% to 29% decreased risk of all-cause mortality (p for trend < 0.001) compared to participants with low levels. Because we determined that gender modified the association between SAA levels and cancer death, we analyzed these associations stratified by gender. Among men, normal to high SAA levels were associated with an approximately 30% decreased risk of cancer deaths, whereas such SAA levels were associated with an approximately two-fold increased risk of cancer deaths among women. This association among women persisted even after adjustment for baseline prevalent cancer and exclusion for early cancer death or exclusion for prevalent cancer.

Conclusions: Low SAA levels were marginally associated with an increased risk of fatal CVD and significantly associated with an increased risk for all-cause mortality. Low SAA levels were also a risk factor for cancer death in men, but unexpectedly were associated with a decreased risk of cancer death in women. If the association between low SAA levels and all-cause mortality is causal, increasing the consumption of ascorbic acid, and thereby SAA levels, could decrease the risk of death among Americans with low ascorbic acid intakes.

Journal of the American College of Nutrition Volume 20, Number 3, June 2001 Relation of Serum Ascorbic Acid to Mortality among US Adults

Joel A. Simon, MD, MPH, FACN, Esther S. Hudes, PhD, MPH, Jeffrey A. Tice, MD General Internal Medicine Section, Medical Service, Veterans Affairs Medical Center (J.A.S.), Department of Epidemiology and Biostatistics (J.A.S., E.S.H., J.A.T.), Division of General Internal Medicine, Department of Medicine (J.A.T.), University of California, San Francisco, California [jasimon@itsa.ucsf.edu]

Submitted by Bill Sardi


While Animal-Based Nutrients Linked With Higher Risk Of Stomach And Esophageal Cancers, Vitamin C supplements reduce stomach cancer by 40%

Date: Posted 10/31/2001

Yale School of Medicine researchers have found that a diet high in cholesterol, animal protein and vitamin B12 is linked to risk of a specific type of cancer of the stomach and esophagus that has been increasing rapidly. The researchers also found that plant-based nutrients such as dietary fiber, dietary beta-carotene, folic acid, vitamin C and vitamin B6 were associated with lower risk of these kinds of cancers. They further found that regular use of vitamin C supplements was associated with a 40 percent reduction in the risk of cancer in the middle and lower parts of the stomach.

The rate of a specific type of esophageal and stomach cancer, known as adenocarcinoma of the esophagus and gastric cardia, has increased by 300 percent since the mid-1970s, according to lead author Susan Mayne, associate professor in the Department of Epidemiology and Public Health at Yale School of Medicine, and associate director of the Yale Cancer Center. To identify reasons for this rapid increase, the United States National Cancer Institute launched a large study at three centers, including Yale, the University of Washington and Columbia University. The researchers interviewed patients throughout Connecticut, New Jersey and western Washington State and compared the nutrient intake of 1,095 people with stomach or esophageal cancer to that of 687 healthy people in a control group. The team also looked at the participants' use of nutrient supplements. Their results are published in the October issue of Cancer Epidemiology, Biomarkers & Prevention.

"We found that many animal-based nutrients found in foods of animal origin are strongly associated with risk of developing these types of cancers and we were able to identify nutrients that presumably would be protective," said Mayne. "We also found that regular users of vitamin C supplements were at significantly lower risk of stomach cancer."

In a separate analysis of these data, the research team found that obesity is strongly linked with risk of these cancers. "The increase in the prevalence of obesity in the United States certainly contributes to the time trends," said Mayne. "Our results suggest that prevention strategies for these cancers should emphasize increased consumption of plant foods, decreased consumption of foods of animal origin with the possible exception of dairy products, and control of obesity."

Other researchers on the study include Principal Investigator of the Yale site Harvey A. Risch and Robert Dubrow at Yale; A. Brian West, previously at Yale and now at New York University Medical Center; Wong-Ho Chow and Joseph F. Fraumeni, Jr. of the U.S. National Cancer Institute; Marilie D. Gammon, previously at Columbia University and now at the University of North Carolina; Habibul Ahsan and Heidi Rotterdam of Columbia University; Janet B. Schoenberg, from the New Jersey Department of Health and Senior Services; Thomas L. Vaughan, Diana C. Farrow and Janet L. Stanford from the University of Washington; and William J. Blot from the International Epidemiology Institute.

Source: Yale University (http://www.yale.edu/)


Study: Vitamin C, E Protects the Aging Brains from Dementia, Improves Cognitive Function

NEW YORK, Mar 27 (Reuters Health) — Taking vitamin C and vitamin E supplements may help protect memory and mental decline as you age, researchers report.

A new study has found that elderly men who took vitamin E and C supplements at least once a week over a number of years were protected from dementia and actually showed improvements in cognitive function — a catch-all term including memory, creativity and mental acuity.

"Vitamin E and C supplements may protect against...dementia and may improve cognitive function in late life," report Dr. Kamal H. Masaki of the Kuakini Medical Center in Honolulu, Hawaii, and colleagues in the March issue of Neurology.

Although a protective effect was seen for two different types of dementia in men who took both vitamins, the supplements did not appear to prevent dementia due to Alzheimer's disease, the authors note.

In the study, Masaki and colleagues looked at supplement use among 3,385 Japanese-American men in 1988, and for a subset of the men, data was collected from 1982 as well. The amount of each vitamin the men took was unknown. The men, who ranged in age from 71 to 93 years, were tested 4 years later in 1993.

At that time, most men were not experiencing any memory problems, although 47 of the men had Alzheimer's dementia, 35 had vascular dementia (a dementia associated with artery-clogging and stroke), 50 had mixed/other types of dementia, and 254 performed poorly on the cognitive tests without diagnosed dementia.

Men who took either vitamin C or E alone in 1988 scored better on the 1993 memory tests than men who took no supplements, the investigators report. Men who took both vitamins exhibited only a small improvement over those taking no supplements.

Masaki and co-authors note, however, that men who took both vitamin E and C supplements together for many years showed a substantially greater improvement, "suggesting that long-term use is required to improve cognitive function in late life."

The researchers believe that vitamin C and E may protect from brain damage because they are antioxidants and can mop up brain-damaging free radical particles. SOURCE: Neurology 2000;54:1265-1272.

Submitted by Robert Dryhurst


Plasma Vitamin C Modifies the Association Between Hypertension and Risk of Stroke.

Stroke 2002 Jun 1;33(6):1568-1573

Plasma Vitamin C Modifies the Association Between Hypertension and Risk of Stroke.

Kurl S, Tuomainen TP, Laukkanen JA, Nyyssonen K, Lakka T, Sivenius J, Salonen JT.

Research Institute of Public Health (S.K., T.P.T., J.A.L., K.N., T.L., J.T.S.), Department of Community Health and General Practice and Inner Savo Health Centre (J.T.S.), and Department of Neuroscience and Neurology and Brain Research and Rehabilitation Centre Neuron (J.S.), University of Kuopio, Kuopio, Finland.

Background and Purpose- There are no prospective studies to determine whether plasma vitamin C modifies the risk of stroke among hypertensive and overweight individuals. We sought to examine whether plasma vitamin C modifies the association between overweight and hypertension and the risk of stroke in middle-aged men from eastern Finland.

METHODS: We conducted a 10.4-year prospective population-based cohort study of 2419 randomly selected middle-aged men (42 to 60 years) with no history of stroke at baseline examination. A total of 120 men developed a stroke, of which 96 were ischemic and 24 hemorrhagic strokes.

RESULTS: Men with the lowest levels of plasma vitamin C (<28.4 µmol/L, lowest quarter) had a 2.4-fold (95% CI, 1.4 to 4.3; P=0.002) risk of any stroke compared with men with highest levels of plasma vitamin C (>64.96 µmol/L, highest quarter) after adjustment for age and examination months. An additional adjustment for body mass index, systolic blood pressure, smoking, alcohol consumption, serum total cholesterol, diabetes, and exercise-induced myocardial ischemia attenuated the association marginally (relative risk, 2.1; 95% CI, 1.2 to 3.8; P=0.01). Adjustment for prevalent coronary heart disease and atrial fibrillation did not attenuate the association any further. Furthermore, hypertensive men with the lowest vitamin C levels (<28.4 µmol/L) had a 2.6-fold risk (95% CI, 1.52 to 4.48; P<0.001), and overweight men (>/=25 kg/m(2)) with low plasma vitamin C had a 2.7-fold risk (95% CI, 1.48 to 4.90; P=0.001) for any stroke after adjustment for age, examination months, and other risk factors.

CONCLUSIONS: Low plasma vitamin C was associated with increased risk of stroke, especially among hypertensive and overweight men.


Vitamin C prevents hyperoxia-mediated vasoconstriction and impairment of endothelium-dependent vasodilation.

Am J Physiol Heart Circ Physiol 2002 Jun;282(6):h2414-21

Vitamin C prevents hyperoxia-mediated vasoconstriction and impairment of endothelium-dependent vasodilation.

Mak S, Egri Z, Tanna G, Colman R, Newton GE.

Cardiovascular Division, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, M5G 1X5 Canada.

High arterial blood oxygen tension increases vascular resistance, possibly related to an interaction between reactive oxygen species and endothelium-derived vasoactive factors. Vitamin C is a potent antioxidant capable of reversing endothelial dysfunction due to increased oxidant stress. We tested the hypotheses that hyperoxic vasoconstriction would be prevented by vitamin C, and that acetylcholine-mediated vasodilation would be blunted by hyperoxia and restored by vitamin C. Venous occlusion strain gauge plethysmography was used to measure forearm blood flow (FBF) in 11 healthy subjects and 15 congestive heart failure (CHF) patients, a population characterized by endothelial dysfunction and oxidative stress. The effect of hyperoxia on FBF and derived forearm vascular resistance (FVR) at rest and in response to intra-arterial acetylcholine was recorded. In both healthy subjects and CHF patients, hyperoxia-mediated increases in basal FVR were prevented by the coinfusion of vitamin C. In healthy subjects, hyperoxia impaired the acetylcholine-mediated increase in FBF, an effect also prevented by vitamin C. In contrast, hyperoxia had no effect on verapamil-mediated increases in FBF. In CHF patients, hyperoxia did not affect FBF responses to acetylcholine or verapamil. The addition of vitamin C during hyperoxia augmented FBF responses to acetylcholine. These results suggest that hyperoxic vasoconstriction is mediated by oxidative stress. Moreover, hyperoxia impairs acetylcholine-mediated vasodilation in the setting of intact endothelial function. These effects of hyperoxia are prevented by vitamin C, providing evidence that hyperoxia-derived free radicals impair the activity of endothelium-derived vasoactive factors.

Contributed by Bill Sardi


Prolonged marginal ascorbic acid deficiency induces oxidative stress in retina of guinea pigs.

Here we see a report that confirms that circulating vitamin C levels differ from tissue levels. The eye has greater need for antioxidants due to its transparent nature and bombardment by solar ultraviolet radiation. In this report, there was no systemic shortage of vitamin C, but there was a shortage in the retinal tissues.

Bill Sardi

Int J Vitam Nutr Res 2002 Mar;72(2):63-70

Ohta Y, Okubo T, Niwa T, Yamasaki T, Horiguchi M.

Department of Chemistry, School of Medicine, Fujita Health University, Toyoake, Aichi 470-1192, Japan. yohta@fujita-hu.ac.jp

We examined whether prolonged marginal ascorbic acid deficiency induces oxidative stress in the retina of guinea pigs. Male guinea pigs aged four weeks were given a scorbutic diet (20 g/animal per day) with either marginally deficient ascorbic acid (0.5 mg/animal per day) or adequate ascorbic acid (1 g/animal per day) in drinking water for three and six months. The retinal contents of the reduced form of ascorbic acid in the deficient group at three and six months were 68.1 and 43.5%, respectively, of that in the corresponding adequate group. The retinal contents of the oxidized form of ascorbic acid in the deficient group at three and six months were 1.9- and 2.7-fold, respectively, higher than that in the corresponding adequate group. The content of retinal thiobarbituric acid reactive substances (TBARS), an index of lipid peroxidation, in the deficient group was 2.5-fold higher than that in the adequate group at six months. The retinal contents of reduced glutathione (GSH) in the deficient group at three and six months were 84.8 and 66.7%, respectively, of that in the corresponding adequate group. The deficient group had 37.5% of retinal vitamin E content of the adequate group at six months. The deficient group had higher serum vitamin E concentration than the adequate group in both experimental periods. There were no differences in serum TBARS and GSH concentrations between the groups at both periods. These results indicate that prolonged marginal ascorbic acid deficiency induces oxidative stress in the retina of guinea pigs without systemic oxidative stress.


Safety of <7,500 Retinol Equivalent (<25,000 IU) vitamin A daily in adults with retinitis pigmentosa.

Am J Clin Nutr 1999 Apr;69(4):656-63

Sibulesky L, Hayes KC, Pronczuk A, Weigel-DiFranco C, Rosner B, Berson EL.

BACKGROUND: Vitamin A supplementation is being used successfully to treat some forms of cancer and the degenerative eye disease retinitis pigmentosa. The daily biological need for vitamin A is estimated to be 800 retinol equivalents (RE)/d (2667 IU/d) for adult women and 1000 RE/d (3300 IU/d) for adult men; doses > or = 7500 RE (> or = 25000 IU)/d are considered potentially toxic over the long term.

OBJECTIVE: We assessed the safety in adults of long-term vitamin A supplementation with doses above the daily biological need but <7500 RE (< 25000 IU)/d.

DESIGN: Adults aged 18-54 y with retinitis pigmentosa but in generally good health (n = 146) were supplemented with 4500 RE (15000 IU) vitamin A/d for < or = 12 y (group A) and compared with a similar group (n = 149) that received 23 RE (75 IU)/d (trace group). Mean total consumption of vitamin A in group A was 5583 RE (18609 IU)/d (range: 4911-7296 RE/d, or 16369-24318 IU/d) and that in the trace group was 1053 RE (3511 IU)/d (range: 401-3192 RE/d, or 1338-10638 IU/d).

RESULTS: Patients in group A showed an 8% increase in mean serum retinol concentration at 5 y and an 18% increase at 12 y (P < 0.001); no retinol value exceeded the upper normal limit (3.49 micromol/L, or 100 microg/dL). Mean serum retinyl esters were elevated approximately 1.7-fold at 5 y and remained relatively stable thereafter. No clinical symptoms or signs of liver toxicity attributable to vitamin A excess were detected.

CONCLUSIONS: Prolonged daily consumption of <7500 RE (<25000 IU) vitamin A/d can be considered safe in this age group.

Foster Biomedical Research Laboratory, Brandeis University, Waltham, MA, USA.

In regards to toxicity symptoms from vitamin A, that would be very rare for people who are healthy. For people with pre-existing liver disease, yes excessive vitamin A may be problematic, but it is the liver that is the problem, not the vitamin A. Yes, they may be hiding the toxic effects of cancer therapy, but if they are treating the liver for cancer then that would make a difference. Vitamin A would be used for epithelial types of cancer like in the stomach, oral, rectal tracts, not brain cancer. The FDA scares people away from high-dose vitamin A. But there are only a few (maybe 30) cases of toxicity annually, while millions are deficient. Those few cases are the people with liver disease. An interesting study was recently conducted among people who are night blind (retinitis pigmentosa) and they were given ~25,000 IU of vitamin A for 5-12 years, with absolutely no toxicity! See above...

Bill Sardi


More beta-carotene and vitamin C, less meat, means longer life for smokers

In yet another report demonstrating beta-carotene and vitamin C's protective effects against cancer, the April 2002 Journal of Nutrition (www.nutrition.org) is the site of the publication of a study showing that male smokers who consume more vitamin C and beta-carotene and less iron (typically derived from meat), had a lower risk of mortality from all causes including cancer, compared to those who consumed less of the vitamins and more iron. The Belgian and Dutch researchers interviewed 2,814 male smokers who were part of the Belgian Interuniversity Research on Nutrition and Health study in order to obtain information concerning dietary habits, and participants completed questionnaires that provided their age, educational level and smoking history and frequency. The researchers determined oxidative balance scores, which reflected the balance between antioxidants, in this case beta-carotene and vitamin C, and prooxidants, which in this case was iron. Blood samples were taken and analyzed for serum total cholesterol and HDL cholesterol.

Ten years following the initial examination, the vital status of each participant was determined. Men who had the highest oxidative balance scores, meaning a diet high in iron and low in vitamin C and beta-carotene, had a higher relative risk of all cause mortality and total cancer mortality. When lung cancer mortality was examined, the group consuming the most beta-carotene and vitamin C was found to have a lower incidence of the disease than the other group The benefit of this dietary pattern on cardiovascular disease mortality risk was not considered significant.

Although iron is essential to human life, high iron stores or intake promote free radical formation. This increased oxidative stress can increase DNA damage and the oxidative activation of precarcinogens, supporting tumor cell growth. Because smokers experience increased oxidative damage, increasing their beta-carotene, vitamin C and other antioxidants, and decreasing the consumption of meat, the major source of dietary iron, may help protect against their increased risk of cancer and allow them a longer lifespan. As vitamin C consumption had been positively correlated with lower mortality from all causes in an earlier study, nonsmokers could benefit from this advice as well.

LIFE EXTENSION WEEKLY UPDATE EXCLUSIVE


Vitamin C intake slows the progression of gastric cancer in Helicobacter pylori-infected populations?

Vitamin C's role in the prevention of disease and malignancy has been studied over the last several decades. Vitamin C intake has been shown to have an inverse relationship with gastric cancer. Recent follow-up studies on high-risk populations suggest that ascorbic acid, the reduced form of vitamin C, protects against gastric cancer, for which H. pylori is a significant risk factor. In populations infected with H. pylori, there is a reduction in gastric juice ascorbic acid concentration. This article reviews the risk factors for gastric cancer and the role of vitamin C in prevention of the disease.

Nutr Rev 2002 Jan;60(1):34-6

Feiz HR, Mobarhan S.

Department of Gastroenterology, Loyola University of Chicago, Maywood, IL 60153, USA.

Contributed by Bill Sardi, Knowledge of Health


Explaining One of Vitamin C's Mechanisms Against Cancer

Writing in The Lancet, scientists from Cornell University and Seoul National University in South Korea offer a more precise explanation for vitamin C's anti-cancer activity. And they suggest that a natural chemical from apples works even better than vitamin C. Their report appears in the Jan. 12 issue of The Lancet, (Vol. 359, No. 9301), the weekly journal for physicians, published in London.C.Y. Lee, Cornell professor of food science and technology, and his South Korean colleagues, Ki Won Lee, Hyong Joo Lee and Kyung-Sun Kang, found that vitamin C blocks the carcinogenic effects of hydrogen peroxide on intercellular communication. Until this finding, the mechanism for vitamin C's inhibitory effects on carcinogenic tumor formation was not understood.

However, the report notes that quercetin, a phytochemical found in apples, has even stronger anticancer activity than vitamin C. (Phytochemicals, such as flavonoids and polyphenols, are plant chemicals that contain protective, disease-preventing compounds.) "Vitamin C has been considered one of the most important essential nutrients in our diet since the discovery in 1907 that it prevents scurvy," says Lee. "In addition, vitamin C has several important functions in our body for the synthesis of amino acids and collagen, wound healing, metabolism of iron, lipids and cholesterol and others. In particular, vitamin C is a well known antioxidant that scavenges free radicals." "Vitamin C prevents the inhibition of gap-junction intercellular communication (GJIC) induced by hydrogen peroxide," says Lee. GJIC is essential for maintaining normal cell growth. Inhibition of GJIC is strongly related to the carcinogenic process, especially to tumor promotion. Hydrogen peroxide, a tumor promoter, inhibits GJIC by changing a special protein, connexin43.

When rat liver epithelial cells were treated with vitamin C, the researchers report, inhibition of GJIC induced by hydrogen peroxide was prevented.Although vitamin C protects against oxidative DNA damage through its free-radical scavenging activity, Lee and his coworkers believe that the vitamin's anti-tumor action functions through a different mechanism."The most powerful weapon we have in the fight against cancer is prevention," concludes Lee. "A diet rich in phytochemicals and vitamin C will reduce the risk of cancer. These phytochemicals and nutrients are most readily available in fresh fruits and vegetables." These recommendations echo those of Lee and his Cornell colleagues in a report in the journal Nature (June 22, 2000)

Contributed by Bill Sardi, Knowledge of Health


Vitamin C Aids Patients with Congestive Heart Failure

A study has demonstrated that vitamin C can aid patients with congestive heart failure (CHF) by suppressing the signal for cell death within blood vessel linings. The study was published in the October 30, 2001, issue of Circulation.

Congestive heart failure patients suffer from endothelial dysfunction, which causes disturbances in the blood vessels and restricts the blood supply to the body, weakening the heart. Increasing evidence points to oxidative stress as the regulator of apoptosis in endothelial cells. The researchers decided to investigate the possibility that antioxident treatment with vitamin C might reduce endothelial cell death in CHF patients. They conducted a randomized, placebo-controlled, double-blinded trial with 34 patients, who received either 2.5 grams of vitamin C or placebo twice daily for four days. On the fifth day, they measured blood levels of circulating apoptotic microparticles. The results showed that vitamin C markedly reduced blood levels of apoptotic microparticles to 32% of baseline levels, while the placebo had no effect.

"The findings might contribute to our understanding of the mechanisms of heart failure progression and could add antioxident treatment as a novel strategy to delay progression of heart failure," said Stefanie Dimmeler, professor of experimental medicine, University of Frankfurt (Germany) and co-author of the study. She noted, however, that it was too early to draw conclusions about the results because of the small number of patients studied.

Found at: http://www.healthy.net/asp/templates/news.asp?Id=3820

By medinews.com staff writers: 14/11/2001 Related Links: Circulation


Contrary to Public Reports, Iron with High Vitamin C Does Not Damage DNA

Iron supplementation and oxidative damage to dna in healthy individuals with high plasma ascorbate.

Proteggente AR, England TG, Rice-Evans CA, Halliwell B.

Previously, we have investigated the potential for a pro-oxidant interaction of iron and ascorbate in vivo in iron and ascorbate cosupplementation or ascorbate supplementation studies. In this study, for the first time, the effects of iron supplementation on oxidative damage to DNA in healthy individuals with plasma ascorbate levels at the upper end of the normal range were examined. Forty female and male volunteers (mean plasma ascorbate approximately 70 µmol/L) were supplemented with a daily dose of syrup (ferrous glycine sulphate equivalent to 12.5 mg iron) for 6 weeks. Serum ferritin, transferrin bound iron, % saturation of transferrin and plasma ascorbate were assessed and the mean dietary intakes of all subjects were estimated through food frequency questionnaires. Oxidative damage to DNA bases from white blood cells was measured by gas chromatography/mass spectrometry with selected-ion monitoring (GC/MS-SIM), using isotope-labeled standards for quantification.

Iron supplementation did not affect any of the iron status parameters. There were also no detrimental effects, over the period under investigation, in terms of oxidative damage to DNA.

Antioxidant Research Group, Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College London, St. Thomas' Street, London, Guy's Campus, SE1 9RT, United Kingdom

Found http://www.ncbi.nlm.nih.gov


Vitamin C Attenuates Healing of Chronic Gastric Ulcers

Department of Physiology, Jagiellonian University School of Medicine, Cracow, Poland.

BACKGROUND: Nonsteroidal anti-inflammatory drugs such as aspirin (ASA) are known to induce gastric mucosal damage including bleeding, ulceration and perforation in humans and experimental animals. These adverse effects of ASA were originally attributed to the inhibition of cyclooxygenase and the deficiency of endogenous prostaglandins induced by this drug but the role of reactive oxygen species (ROS), lipid peroxidation and antioxidizing mechanism in the pathogenesis of ASA damage has been little studied. New class of nitric oxide (NO)-releasing nonsteroidal anti-inflammatory drugs was shown to inhibit cyclooxygenase and prostaglandin generation without causing mucosal damage but it remains unknown whether these agents affect the healing process of chronic gastric ulcers.

MATERIAL AND METHODS: In this study the effect of NO-releasing aspirin (NO-ASA) and was compared with that of native aspirin applied with or without vitamin C on the healing of acetic acid ulcers. The area of gastric ulcer was determined by planimetry, the gastric blood flow (GBF) at ulcer margin was measured by h2 gas clearance method and mucosal release of ROS was quantified by measuring the chemiluminescence before and after the treatment with ASA or NO-ASA alone and ASA combined with vitamin C. The plasma antiinflammatory cytokine such as IL-1b and oxygen radical-mediated lipid peroxidation was measured in the ulcerated gastric mucosa of ASA and NO-ASA-treated animals.

RESULTS: ASA delayed significantly ulcer healing and this effect was accompanied by a marked increase in the chemiluminescence, lipid peroxidation and the fall in the GBF at ulcer margin. Vitamin C attenuated significantly both the ASA-induced gastric damage and accompanying fall in the GBF at ulcer margin and the rise in the chemiluminescence and reversed the ASA-induced lipid peroxidation. In contrast, NO-ASA failed to affect healing of gastric ulcers and failed to produce the rise in the plasma IL-1b levels and the increase of lipid peroxidation as compared to those recorded in ASA-treated animals.

CONCLUSIONS: 1) ROS-induced enhancement in lipid peroxidation plays an important role in the mechanism of gastric damage induced by ASA, 2) vitamin C attenuates the deleterious effect of ASA on ulcer healing due to its antioxidizing activity by mechanism involving preservation of gastric microcirculation and attenuation of lipid peroxidation and cytokine release and 3) coupling of NO to aspirin fails to delay the ulcer healing suggesting that NO might compensate for prostaglandin deficiency induced by NSAID

Med Sci Monit 2001 Oct;7(4):592-599

Brzozowski T, Kwiecień S, Konturek PC, Konturek SJ, Mitis-Musiol M, Duda A, Bielański W, Hahn EG.

Contributed by Bill Sardi


Study: Vitamins Found to Prevent Stomach Cancer

© 2000 by Ralph Moss

It was a pleasant surprise to see the National Cancer Institute stating that vitamin C and beta carotene may prevent stomach cancer. This was the conclusion of a randomized clinical trial carried out in the country of Columbia (J Natl Cancer Inst 2000;92:1881-1888). More than 600 people at high risk of developing stomach cancer were given one gram of vitamin C twice per day; 30 milligrams of beta-carotene; an antibiotic to combat H. pylori infection (a cause of stomach cancer), or a combination of these three treatments; or a placebo pill.

Scientists biopsied pre-cancerous growths in the stomachs of all participants. Such abnormalities were four times as likely to shrink or disappear among those who received any of the three active treatments compared to placebo. Since stomach cancer is the second leading type of cancer worldwide, " an effective means of preventing the disease could have a dramatic impact on public health worldwide" - to quote the NCI website. Notice that some participants received 2,000 milligrams per day of vitamin C, the same "mega-doses" that just last year we were warned might cause tumors to grow explosively. In reality, they made these pre-cancerous stomach lesions shrink.

Found in the Townsend Letter


Vitamin C Improves Heart's Own Circulation in Smokers

A team of British and Swiss Researchers report that smoking affects blood circulation (microcirculation) within the heart itself. The study involved eight healthy male non-smokers (controls) and eleven long-term smokers, with no signs of heart disease. The researchers used positron emission tomography (PET scanning) to measure coronary flow reserve (CFR) of the participants before and after the infusion of three grams of vitamin C (ascorbic acid). CFT is the ration between maximal blood flow within the heart and blood flow at rest. A high CFR is beneficial. The researchers found that the smokers had an average 21% lower CFR than the controls, but that vitamin C infusion corrected the deficiency and brought the smokers' CFR levels back to the level of the non-smokers. The vitamin C infusion had no effect on the non-smokers. The researchers conclude that the damaging effects of smoking are at least partially caused by excessive oxidative stress. They suggest a large-scale trial to determine if daily oral supplementation with vitamin C can prevent the development of coronary artery disease in smokers.

Found in Alternative Healthcare Management


500 mg Vitamin C Reduced High Blood Pressure: Study

Scientists at the Linus Pauling Institute (LPI), in conjunction with the Boston University School of Medicine, recently completed a study of the effect of vitamin C on blood pressure, which produced encouraging results. In the placebo-controlled, double-blind study, 45 patients with high blood pressure (a diastolic blood pressure of more than 90 and a systolic of more than 140 mm Hg) were given 500 mg of vitamin C per day. After one month, blood pressures declined an average 9%.

Found in Alternative Healthcare Management


Oral Vitamin C Benefits Arteries and Platelets

Atherosclerosis is associated with stiffening of arteries and increased platelet activation. This is partly a result of reduced bioavailability of nitric oxide (NO). The NO molecule normally has a variety of protective effects on blood vessels and platelets. Increased levels of oxygen free radicals reduce NO bioavailability when atherosclerosis is present and might lead to increased arterial stiffness and platelet activation.

Vitamin C, being a dietary antioxidant, inactivates oxygen free radicals. After acute oral administration of vitamin C (2 gm), vitamin C blood concentrations increased from 42 to 104 (mu M) at 6 hours after oral administration. It was associated with a significant reduction in augmentation index, which is a measure of arterial stiffness (by 9.6), and ADP-induced platelet aggregation (by 35). There was no change in these parameters in the placebo group.

Vitamin C, therefore, appears to have beneficial effects, even in healthy subjects. The mechanism responsible is likely to involve protection of nitric oxide from inactivation by oxygen free radicals. If similar effects are observed in patients with atherosclerosis or risk factors, vitamin C supplementation might prove an effective therapy in cardiovascular disease. Journal of Cardiovascular Pharmacology, 1999, Vol 34, Iss 5, pp 690-693.

Found in March 2000 Life Extension Magazine, Pg. 72


Study: Vitamin C Reduces Dangerous Blood Levels of Lead

At the University of California at San Francisco, test results have proven Vitamin C can reduce dangerous blood levels of lead, a condition that can harm neurological development in children. High dosages of vitamin C are associated with reduced blood levels of lead in both young children and adults, which can have "public health implications," according to Dr. Joel Simon and Dr. Esther Hudes. They revealed their findings in a recent issue of the Journal of the American Medical Association (JAMA). Their study involved more than 19,000 people, who were as young as six years of age. Children who ranked in the top third of vitamin C intake had an 89 percent lower incidence of high lead levels in their blood. Similar tests on adults showed a 68 percent reduction.

Found in Sep/Oct 99 Alternative Healthcare Management


Vitamin C RDA Increase Urged

The Journal of the American Medical Association (JAMA) published a report on April 21, 1999 that the RDA of vitamin C should be raised from 60 mg to at least 200 mg. The following AP article reports on recent rat studies which make the case that high dose vitamin C is highly beneficial even though rats, unlike humans, make their own vitamin C.

Tue Aug 23 1999 — NEW ORLEANS (AP) — Megadoses of vitamin C reduced the effects of stress in rats and apparently can help boost the production of an illness-fighting antibody, a researcher says.

In light of the findings, health agencies should consider increasing the recommended dose of the vitamin in humans, now based on the amount needed to prevent scurvy and anemia, said P. Samuel Campbell, chairman of the biological sciences department at the University of Alabama at Huntsville.

His speech Sunday to the American Chemical Society came almost five years after the death of Linus Pauling, the Nobel-winning chemist who suggested in the 1970s that large doses of vitamin C might prevent colds and other ailments.

Campbell and his colleagues immobilized a group of rats for an hour a day to stress them. A control group was not immobilized.

In both animals and people, the adrenal glands react to stress by releasing hormones that trigger the "fight or flight" reaction. The researchers found that 200 milligrams of vitamin C a day reduced the levels of stress hormones in the rats' blood.

The dose is the equivalent of several thousand milligrams a day in people — far beyond the current recommended level of 60 milligrams. More than a thousand milligrams (one gram) a day can cause nausea, stomach cramps, diarrhea and, occasionally, kidney stones, according to The American Medical Association Encyclopedia of Medicine.

Stress also suppresses the immune system, and Campbell found that megadoses of vitamin C increased the levels of an antibody — which fights against germs and viruses — in both stressed and unstressed rats.

However, the increase in antibody level was greater in the unstressed rats, suggesting that stressed animals may need larger vitamin doses to keep the immune system going, Campbell said.

Vitamin C also reduced other indicators of stress, such as loss in body weight, enlargement of the adrenal glands and reduction in the size of the spleen and thymus gland, he said.

AP, Aug 23 1999

Found at newsday.combad link


NIH Team: Use Vitamin C for Antibiotic Resistant Bacteria

Like police using tear gas to quell a riot, immune system cells that throw corrosive chemicals on invading bacteria may use a kind of chemical gas mask to protect themselves--and healthy tissue--from their own weapon. Scientists have found that vitamin C may serve as just such a shield to save a key type of immune cell from self-annihilation, according to a report in the 9 December Proceedings of the National Academy of Sciences.

Immune cells called neutrophils destroy bacteria with a two-stage attack: First, they produce oxidants that puncture a bacterium's cell walls, then the neutrophils engulf the disabled bug. Recent work by Mark Levine's group at the National Institutes of Health has hinted that neutrophils may avoid poisoning themselves by absorbing extra ascorbic acid, or vitamin C, which can neutralize oxidants.

To test this theory, a team led by Levine and Yauhui Wang collected neutrophils from people with bacterial infections and incubated the cells for up to an hour in two sets of dishes stocked with vitamin C and nutrients. One set was infected with bacteria; the other was clean. Within 20 minutes, the neutrophils from the infected dishes had accumulated up to 30 times more vitamin C than those in bacteria-free dishes. The researchers also found that neutrophils from people with the rare chronic granulomatous disease, which makes them especially vulnerable to bacterial infections, did not accumulate vitamin C when confronted with bacteria.

Vitamin C stockpiling "could be a very clever way that the neutrophils protect themselves," says biologist John Curnutte of Genentech Inc. in San Francisco. But he and Levine caution that neutrophils may behave differently in the body than in the lab. The key question, adds cell biologist Sam Silverstein of Columbia University in New York City, is whether dosing up on vitamin C makes a person's neutrophils better bacteria killers. If so, Levine says, vitamin C could be an approach to tackling antibiotic-resistant bacteria.

Found in Science December 1997; 278: 2061c-2063c.


Pauling DNA Model Partially Confirmed

Pauling detractors have often commented on his mistaken model for the DNA helix. Now this:

In another development late last year, Dr. Jean-Francois Allemand and his French colleagues published a report in the Proceedings of the National Academy of Sciences U.S.A. that described another stable form of DNA, which is usually conformed as a double helix. In 1953, Pauling and Corey proposed a triple-helical structure for DNA that positioned the phosphate groups on the inside of the helix. A few months later, Watson and Crick proposed the double helix, which was quickly accepted as the correct structure and led to a Nobel Prize. Dr. Allemand and his colleagues have identified a helical form of DNA, termed P-DNA, that shares with the Pauling-Corey model the feature of having the phosphate backbone on the inside of the structure and the bases exposed. The authors propose that this form of DNA may occur during DNA replication and transcription.

Found at Linus Pauling Institute


Vitamin C improves function of arteries

Chronic Heart Failure (CHF) is associated with endothelial cell dysfunction. These cells line the cavities of the heart. There is evidence for increased free radical formation in CHF. This raises the possibility that nitric oxide (NO) is inactivated by the free radicals, thereby impairing endothelial function. Nitric oxide causes dilation of the blood vessels and is derived from L-arginine in endothelial cells, macrophages, neutrophils, platelets, etc. It is a gaseous mediator of cell-to-cell communication formed in bone, brain, endothelium granulocytes, pancreatic cells, and peripheral nerves. The short-lived NO molecule is manufactured by tissues, and plays a role in various processes, primarily by interacting between endothelium and smooth muscle cells. It is involved in dilation of blood vessels and penile erection, and possibly affects immune reactions and memory. Shortage or inactivation of NO may contribute to high blood pressure and formation of atherosclerotic plaque. An excess of NO, which is a free radical, is toxic to brain cells, and NO is also responsible for the often fatal, drop in blood pressure accompanying shock from abdominal or pelvic infection.

This study tested the hypothesis that (NO) is inactivated by free radicals, by determining the effect of vitamin C (25 mg/min) on impaired dilation in patients with CHF, it consisted of 15 patients with CHF and 8 healthy volunteers. An excitotoxic amino acid was used to inhibit endothelial synthesis of nitric oxide. The result was that vitamin C restored impaired endothelium function in patients with heart failure after both intra-arterial administration (13.2% vs. 8.2%) and oral therapy (11.9% vs 8.2%) for 4 weeks. The portion of dilation mediated by nitric oxide (which was inhibited by the excitotoxic amino acid) was increased after acute as well as after chronic treatment (CHF baseline: 4.2%, acute 9.1%, chronic 7.3%; normal subjects: 8.9%).

Thus vitamin C improved arterial dilation in patients with CHF as the result of increased availability of nitric oxide. This supports the concept that endothelial cell dysfunction in patients with CHF is, at least in part, due to the accelerated degradation of nitric oxide by free radicals.

Circulation, 1998, Vol 97, Iss 4, pp 363-368.

Found in August 1999 Life Extension Magazine


Lens vitamin C levels decrease in more severe cataracts

The concentration of vitamin C measure in 48 human lenses with cataracts, which were graded in terms of degrees of opacity and browning (protein oxidation). Lens vitamin C concentrations were inversely correlated with the severity of lens opacity. Dark brown, opaque lenses contained nearly 50% less vitamin C than lenses with mild cataracts. Increased lens opacity also reflected increasing levels of modified lens protein. The authors conclude that vitamin C is a good indicator of cataract severity, and that oxidation plays a role in cataract progression.

Comment by Robert A. Ronzio, PhD:

The concentration of vitamin C in the lens is normally one of the highest of any human tissue. As a major water-soluble antioxidant, vitamin C plays a pivotal role in maintaining cellular defenses against oxidative damage. Possibly low vitamin C could decrease lens antioxidant defenses, such as glutathione. In turn this could favor cross-linking , and creation of insoluble gamma crystalline aggregates. When vitamin C is degraded (oxidized), it promotes glucose attachment to proteins, the oxidation of tryptophan residues in polypeptide chains, and protein cross-linking. This type of experiment does not permit a distinction between low vitamin C as a cause or as an affect of AMD.

Tessier, F., et al. Decrease in Vitamin C concentrations in human lenses during cataract progression. Int. J. Vitamino Nutr Res 1998;68:309-15

Found in July 1999 Townsend Letter for Doctors and Patients


Vitamin C may reduce the risk of cataract development

Vitamin C use over a 10-12 year period was compared with the development of age-related lens opacities in 247 women without diagnosed cataract or diabetes. The subjects were participants of the Nurses' Health Study and their mean age was 62.6 years at the time of eye examinations. The use of vitamin C supplements for 10 or more years was associated with a significant 77% lower prevalence of early lens opacity as compared with women who did no use vitamin C. The use of vitamin C for less than 10 years did not correlate with decreased risk of early lens opacities.

Comment by Robert A. Ronzio, PhD: A major disadvantage of the sampling scheme is that it permitted the investigators to compare the frequency of supplementation, but not the amounts of supplemental vitamin C or vitamin C consumption, and the degree of cataract development. In any case, this study emphasizes the importance of ample antioxidants for decades in order to obtain the most benefit for eye health.

Jacques PF, Taylor A. Hankinson SE. et al, Long-term vitamin C supplement use and prevalence of early age-related lens opacities. Am J. Clin Nutr 1997;66:911-6.

Found in July 1999 Townsend Letter for Doctors and Patients


Cathcart: Dramatic Oral Vitamin C Effects are Always with Ascorbic Acid

I noticed that in your news item about the flu, it was not entirely clear that the dramatic effects are always with ascorbic acid orally and sodium ascorbate intravenously. I have not been able to achieve the ascorbate effect with mineral ascorbates orally. Mineral ascorbates are fine forms of vitamin C but when you are really sick, the mitochondria are failing in their refueling of the free radical scavengers with electrons. The ascorbic acid carries 2 extra electrons per molecule where the mineral ascorbates seem to carry only one (plus per molecule the mineral ascorbates are heavier due to the mineral weighing more than the hydrogen the mineral replaces). So the mineral ascorbates are not potent enough to accomplish the ascorbate effect. There may be other reasons that we do not appreciate additionally.

See http://www.orthomed.com/bird.htm - Robert Cathcart, MD


Jan 98 — Foundation Applies for NIH/Office of Alternative Medicine Grant

The Vitamin C Foundation proposes to sponsor the first study ever of the Linus Pauling so-called "Unified Theory" of cardiovascular disease. Foundation technical advisors Warren M. Levin, MD and Robert Cathcart, III, MD, have volunteered to conduct the study, with Dr. Levin accepting responsibility as Principal Investigator. The Foundation is applying for a grant from the National Institute of Health, Office of Alternative Medicine. If approved, this will be the first study of the role of vitamin C, lysine and proline on heart disease in humans.

Foundation Seeking Study Participants

If you have been diagnosed with heart disease, i.e., have had angioplasty or coronary by-pass graph operations, and you are willing to participate in this "first ever" study of Pauling's heart disease therapy, and are not now or never have been taking lysine and proline for this condition, and if you live near, or are willing to travel to the New York City and Los Altos, CA, area, then please contact the Foundation: Lp(a) Study, Box 3097, Lisle, IL 60532

Study participants will receive free exams and "medication" but no study participant will be deprived of vitamin C.

- Owen Fonorow


Cathcart: Vitamin C in High Dosages Provides Significant Pain Relief

This just in from a Vitamin C Foundation technical adviser in Los Altos, CA:

The day before Thanksgiving I had a cornea transplant. When the local began to wear off, it became obvious that it was going to be painful. I began taking 12 grams of ascorbic acid orally every 15 minutes. By the time I reached 72 grams, there was absolutely no pain.

I continued to take 8 to 12 grams and hour that evening and the following day. There was no pain.

Thanksgiving, I returned for a follow-up visit. There had been 2 cases of corneal transplant done the day before. There were no nurses in that day so the doctor came in to do the follow-up by himself. He called both of us in at the same time. As we were walking down the hall together, he asked me if I had pain, I told him about the 72 grams of ascorbate (vitamin C) and told him there was no pain. He asked the other patient the same thing and he replied that it had hurt terribly the night before and still hurt terribly.

Subsequently, the eye incision healed rapidly and there was not pain. The corneal edema, which was the reason for the operation, was due to an old style cataract operation where the lens was placed anterior to the iris and just behind the cornea. (The more modern method is to place the lens posterior to the iris.) Anyway, it was a Leiske lens and a common complication is that it somehow damages the endothelium of the cornea. The cornea grows from the inside out. As little pockets of damaged cells grow toward the surface, it results in corneal edema and corneal ulcers.)

The reason that ascorbate (only in very high doses) is such a good pain killer is because the pain is medicated by free radicals and if there are no free radicals, there is no pain. The important thing to remember is that the ascorbate has to be forced into the tissues involved in very high concentrations before the ascorbate has this pain killing effect.

- Robert Cathcart, MD


Effects of oral vitamin C on monocyte: endothelial cell adhesion in healthy subjects.

Biochem Biophys Res Commun 2002 Jun 28;294(5):1161-1168

Effects of oral vitamin C on monocyte: endothelial cell adhesion in healthy subjects.

Woollard KJ, Loryman CJ, Meredith E, Bevan R, Shaw JA, Lunec J, Griffiths HR.

Pharmacology Research Group, PSRI, Aston University, Aston Triangle, Birmingham B4 7ET, UK

Monocyte recruitment and retention in the vasculature is influenced by oxidative stress and is involved in cardiovascular disease (CVD). Individuals with low plasma ascorbate are at elevated risk of CVD. It is unknown whether vitamin C supplementation affects monocyte adhesion to endothelial cells (ECs) in healthy non-smokers. In a randomised double-blind crossover study the effect of vitamin C supplementation (six weeks, 250 mg/day) was determined in subjects with normal (HIC) and below average (LOC) plasma vitamin C concentration at baseline (mean=67 µM,n=20,mean=32 µM,n=20, respectively). LOC subjects showed 30% greater monocyte adhesion to ECs. This was significantly reduced by 37% (P<0.02) following vitamin C supplementation to levels of HIC monocyte adhesion. No differences in plasma malondialdehyde concentrations were observed between groups or after supplementation. In conclusion, vitamin C supplementation normalises monocyte adhesion in subjects with low plasma vitamin C (LOC). This process may be related to a direct effect on monocytes, independent of lipid peroxidation. (c) 2002 Elsevier Science (USA).

Submitted by Bill Sardi


Progress Report on the War Against Scurvy


Vitamin C - Old News Archives

Newsletter #4 (Aug 2012)
  • Study: Long Term Use of Antioxidant Supplements Cuts Risk of Breast Cancer in Half
  • Study: High Antioxidant Intake Significantly Decreases Pancreatic Cancer Risk (by 67%).
  • Study: Vitamins C, E Cut Prostate Cancer Risk
  • Study: Vitamins C, E and Selenium Drastically Reduce Risk of Death From Gastric (Stomach) Cancer and Esophageal Cancer
  • Study: Even small amounts (500 mg) of Vitamin C Improves Pulmonary Function in Newborns of Pregnant Women Who Smoke.
  • Study: Intravenous Injection of Vitamin C Can Help Relieve Pain of Shingles.
  • Study: Low Dose Vitamins C/E Benefit Women on Oral Contraceptives
  • Study: Asthma/COPD Worse when Vitamin C Blood Levels Low
  • Study: A Novel Animal Model of Vitamin C and Heart Disease
  • Celebrities Flocking to Health and Wellness Centers for Intravenous Vitamin and Mineral Therapy Sessions.
  • Report: Woman Refuses Drugs and Chemo to Battle Breast Cancer with Vitamin C and Fresh Veg.
  • “Moderate” Doses of Vitamin C May Lower Blood Pressure
  • Reversing Heart Disease with A Vitamin – Daniel Cobb, DOM
  • New Book: The Patented Heart Disease Cure that Works


Newsletter #3 (Sep 2011)
  • Vitamin C Rapidly Improves Emotional State of Acutely Hospitalized Patients
  • Vitamin K3 and vitamin C Alone or in Combination Induced Apoptosis in Leukemia Cells by a Similar Oxidative Stress Signaling Mechanism
  • Mayo Clinic to study Vitamin C and K3 “Drug” for Cancer
  • New Function of Vitamin C: Treating Alzheimer's Disease
  • New Cancer Imaging Technique Uses Vitamin C to Detect More Aggressive Tumors
  • Vitamin C Strengthens Brain and Eye Function


Newsletter #2 (Mar 2010)
  • Vitamin C increases the Production of Induced Stem Cells
  • Non-Toxic Vitamin C Inhibits Formation of New Blood Vessel Growth to Tumors
  • Vitamin C Improves Myocardial Perfusion in Elective PCI
  • Vitamin C, E, Omega 3-fatty acids Prevent Pancreatic Cancer
  • Vitamin C Protects Against Hypertension-Induced DNA Damage
  • Vitamin C 'Cures' Mice With Accelerated Aging Disease
  • Vitamin C and other Supplements May Be Key to Preventing Diabetic Retinopathy
  • IV/C Can Save Your Cat's Life Too


Newsletter #1 (Feb 2009)
  • Researchers Stop Diabetes Damage with High C
  • Men Who Take Vitamin C Supplements are Less Likely to Develop Gout
  • Low Vitamin A, C & E Increases Asthma Risk
  • Higher Plasma Vitamin C Levels Linked with Lower Diabetes Risk
  • Vitamin C Stops the Growth of Cancerous Tumors in Mice
  • Vitamin C has Crucial Anti-aging Properties: Study
  • Vitamin C Improves Dark Circles
  • Vitamin C and Blood Pressure Linked
  • Mega-C Reduced Colds/Flu 85% (clinical study)

Science Articles

  1. UK: Jul 28, 2008: Higher Plasma Vitamin C Levels Linked with Lower Diabetes Risk: Study of 21,831 from 1993 to 2005 So, why did it take 2.5 years for this to be published in a medical journal?
  2. Vitamin C linked to lower stroke risk: study
    Increased blood levels of vitamin C may reduce the risk of stroke by 42 per cent, suggests a large European-based study.
  3. Prenatal vitamins shown to reduce children's risk of cancer...
  4. Vitamin C protects against cataract...bad link
  5. Vitamin C and omega-3 fatty acids help teens overcome asthma...bad link
  6. Human adrenal glands secrete vitamin C in response to adrenocorticotrophic hormone
  7. FDA OKs vitamin C trial for cancer at Cancer Treatment Centers of America...
  8. Large study finds vitamin C protective of stomach cancer...
    But when the researchers examined the blood levels of vitamin C they found a strong protective effect. That is: they found that those subjects with the highest level of vitamin C in their blood had a 60 percent lower risk of stomach cancer than those subjects with the lowest levels.
  9. Vitamin C Improves Dark Circles
    Japanese researchers found vitamin C may improve dark circles of the lower eyelid (DCLE) by thickening the eyelid dermis and concealing dark coloration due to congested blood.
  10. Positive Effect of ascorbic acid (vitamin C) on prevention of hypercholesterolemia induced atherosclerosis in rabbits...
    The notion that oxidation of lipids and propagation of free radicals may contribute to the pathogenesis of atherosclerosis is supported by a large body of evidence.

    Low dose of ascorbic acid (0.5 mg/100 g body weight/day) did not have any significant effect on the percent of total area covered by atherosclerotic plaque. However, ascorbic acid when fed at a higher dose (15 mg/100 g body weight/day) was highly effective in reducing the atherogenecity. With this dose the percent of total surface area covered by atherosclerotic plaque was significantly less (p < 0.001). This suggests that use of ascorbic acid may have great promise in the prevention of hypercholesterolemia induced atherosclerosis.

  11. Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in Type 2 diabetes...

  12. High Cholesterol Levels May be Controlled by Vitamin C, According to a San Diego Researcher

  13. Harvard team grows heart muscle

  14. Ascorbic acid improves the intrahepatic endothelial dysfunction of patients with cirrhosis and portal hypertension...

  15. Vitamin C Beats Bird Flu and Other Viruses, Too...
  16. Vitamin C supplements help reverse male infertility...bad link
  17. Treat Your Scars With Vitamin C...bad link
  18. Effect of intravenous ascorbic acid in hemodialysis patients with EPO-hyporesponsive anemia and hyperferritinemia...
    CONCLUSION: In hemodialysis patients with refractory anemia and hyperferritinemia, vitamin C improved responsiveness to EPO, either by augmenting iron mobilization from its tissue stores or through antioxidant effects.
  19. Effect of Ascorbic Acid Supplementation on Certain Oxidative Stress Parameters in the Post Reperfusion Patients of Myocardial Infarction...
    "Supplementation of vitamin C to the post reperfusion patients restored these parameters back to normal or near normal levels" - May 2006
  20. Combined vitamin C and E deficiency results in severe central nervous system damage in a matter of days...bad link
  21. Unified Theory of Human Cardiovascular Disease Leading the Way to the Abolition of This Disease as a Cause for Human Mortality (1992)...bad link
  22. High-Dose Vitamin C A New Therapeutic Approach...
  23. Vitamin C deficiency increases the lung pathology of influenza virus-infected gulo-/- mice...
  24. Antioxidant micronutrients in major trauma and burns: evidence and practice...
  25. IVC Cured West Nile - Case Ignored by Boulder Colorado Health Department...bad link
  26. Orange Juice Prevents Kidney Stones...
  27. Analysis: Vitamin C loss and Alzheimer's...bad link
  28. Vitamin C Acts As Anti-inflammatory Agent ...bad link Vitamin C combats hypertension...bad link
  29. Effect of ascorbic acid (vitamin C) on prevention of hypercholesterolemia induced atherosclerosis...
  30. Smokers: supplements of vitamin C can stop the serious depletion of vitamin E...
  31. Abnormal spermatogenesis in mice unable to synthesize ascorbic acid (Vitamin C)...
  32. Vitamin C Can Boost the Immune System...bad link
  33. Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E(2) production...
    "Further, these experiments suggest that a combination of aspirin with ascorbic acid constitutes a novel approach to render COX-2 more sensitive to inhibition by aspirin, allowing an anti-inflammatory therapy with lower doses of aspirin, thereby avoiding the side effects of the usually high dose aspirin treatment.
  34. Nutritionist Refutes Anti-vitamin Article in Wall Street Journal ...
  35. Harvard: Free Radical Production Increases with Age and Overwhelms the Body's Antioxidant Defenses...bad link
    "A common molecular denominator in aging and many age-related diseases is oxidative stress."
  36. Judge allows teen cancer patient to seek IV Vitamin C treatment at Mexican clinic...bad link
  37. Low vitamin C intake tied to asthma risk...
  38. Nigeria: Vitamin C Can Help Suppress HIV/Aids Virus -Experts... REPORT OF THE INDEPENDENT VITAMIN SAFETY REVIEW PANEL...
  39. Monosodium glutamate-induced oxidative damage and genotoxicity in the rat: modulatory role of vitamin C, vitamin E and quercetin...
    Co-treatment of rats with VIT C and quercetin inhibited the induction of MNPCEs by MSG (P < 0.001). VIT E failed to protect against MSG-induced genotoxicity. The results indicate that dietary antioxidants have protective potential against oxidative stress induced by MSG and, in addition, suggest that active oxygen species may play an important role in its genotoxicity.
  40. Vitamin C blocks vascular dysfunction and release of interleukin-6 induced by endothelin-1 in humans in vivo.
  41. Antioxidant Vitamin C Improves Endothelial Function in Obstructive Sleep Apnea.
    blinded, controlled trial.
  42. Dentist says vitamin C, calcium good for dental health...
  43. Woman With Cancer Claims Vitamin C Saved Her Life...bad link
  44. Nutritional Value Of Hospital Food: Vitamin C Levels Well Below Published Standard...
  45. Vitamin C, water have "dramatic" benefits for plastic manufacturing...bad link
  46. Vitamin C supplements help maintain vitamin E in smokers...bad link
  47. University of Chicago: Vitamin C treats avian flu better that current drugs...

  48. Diet Rich In Vitamin C Linked To Better Lung Function...
  49. Asthma Sufferers: More Vitamin C = Less Medication...
  50. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues ...
  51. Ascorbic Acid (Vitamin C) Kills Cancer Cells...
  52. Vitamin C Beats Bird Flu and Other Viruses, Too...
  53. Better Than A Flu Shot - Vitamin C Does The Trick...
  54. Colds 'may trigger child cancers' ...
  55. Chances of Surviving Throat Cancer Improve on Diet Rich in Vegetables and Vitamin C...
  56. Avian Bird Flu Treatment... Dr. Cathcart's Page on the new influenza threat...
  57. Management of fatty liver disease with vitamin E and C compared to ursodeoxycholic acid treatment...
    CONCLUSION: [Even Low Amounts] "Vitamin E plus C combination treatment is a safe, inexpensive and effective treatment option in patients with fatty liver disease, with results comparable to those obtained with ursodeoxycholic acid. Since more effective new therapeutic options are lacking, patients with fatty liver disease should be encouraged to take vitamin E and C supplements, which are safe and affordable."
  58. Evidence that the administration of Vitamin C improves a defective cellular transport mechanism for iodine...bad link
  59. A Cure for Lyme Disease?
  60. Cancer: Intravenous Vitamin C Effective Treatment
  61. Annals of Internal Medicine: Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use ...
  62. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues...
  63. Final Report of the Safety Assessment of [Vitamin C] i.e., L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as Used in Cosmetics...
  64. Hypoxia studied, protective role of vitamin C defined ...
  65. Raising Vitamin C in Plants Can Reduce Smog Damage...
  66. Scurvy, a re-emerging disease...
  67. Association between plasma lipoprotein(a) concentration and restenosis after stent implantation...
  68. Vitamin C inhibits platelet aggregation ...
  69. Strategies for healthy weight loss: from vitamin C to the glycemic response...
  70. Vitamin C: Good for Gout...
  71. Patients With Severe Asthma Benefit from Increased Vitamin C Intake...
  72. The effects of vitamin C supplementation on serum concentrations of uric acid...
  73. India Researchers: "Vitamin C merits close scrutiny for the treatment of heart disease"...
  74. Increased plasma vitamin C significantly lowers heart attack risk...bad link
  75. Vitamins significantly reduce their risk of developing Alzheimer's disease...
  76. Antioxidant effects of combined vitamins C and E in acute myocardial infarction...
  77. Vitamin C Prevents Stroke ...bad link
    "A new Dutch study finds people with the lowest amount of vitamin C in their diets were 30 percent more likely to have a stroke than people with the highest amount of it."
  78. Vitamin E Reduces Risk of Bladder Cancer ...
    "Researchers discovered that the higher the intake of vitamin E, the greater amount of protection offered."
  79. High antioxidant vitamin intakes reduce adverse effects of chemotherapy in children with acute lymphoblastic leukemia...
  80. Nobelist Ignarro USC study finds supplements may prevent atherosclerosis...bad link
  81. Vitamins C & E Cut ICU Deaths in Half...
  82. Antioxidant intervention blunts renal injury ...
  83. Inhibition of liver cancer cell proliferation and migration with ascorbic acid (vitamin C)...
  84. Combination therapy with vitamins C plus E inhibits human prostate cancer cell growth...
  85. John Hopkins University has now found that combining vitamin E and vitamin C supplements can dramatically reduce the risk of Alzheimer's ...bad link
  86. Vitamin C reverses osteoporosis in mice...
  87. Vitamin E Cuts Bladder Cancer Risk by 50%...
  88. Vitamin C Boosts Immune System in as Little as 5 hours.
  89. Vitamin C Research: 'Important New Treatment of Respiratory Disorders'...bad link
  90. Lowered plasma vitamin C, but not vitamin E, concentrations in dementia patients...
  91. LOOK HERE!!!!!
  92. Even 'vitamin-like' supplementation with combination of vitamin E and vitamin C slows atherosclerosis...
  93. U.N. Researchers said they could predict 62 percent of heart disease deaths by looking at blood levels of vitamin E...
  94. Common Nutrients Fed To Pregnant Mice Lowered the Offspring's Susceptibility to Obesity, Diabetes and Cancer...
  95. Ames: High Dose Vitamins can Treat more then 50 Genetic Disorders
  96. Vitamin C Does Not Cause Kidney Stones! Fourteen Year Study of 85,557 implicates low vitamin B6, exonerates Vitamin C.
  97. NUTRIENT CHOLINE DURING PREGNANCY 'SUPER-CHARGES' CHILD'S BRAIN FOR LIFE...
  98. Vitamin C Boosts Immune System in as Little as 5 hours.
  99. Vitamin C Research: 'Important New Treatment of Respiratory Disorders'...bad link
  100. Lowered plasma vitamin C, but not vitamin E, concentrations in dementia patients...
  101. LOOK HERE!!!!!
  102. Even 'vitamin-like' supplementation with combination of vitamin E and vitamin C slows atherosclerosis...
  103. U.N. Researchers said they could predict 62 percent of heart disease deaths by looking at blood levels of vitamin E...
  104. Common Nutrients Fed To Pregnant Mice Lowered the Offspring's Susceptibility to Obesity, Diabetes and Cancer...
  105. Ames: High Dose Vitamins can Treat more then 50 Genetic Disorders
  106. Vitamin C Does Not Cause Kidney Stones! Fourteen Year Study of 85,557 implicates low vitamin B6, exonerates Vitamin C.
  107. NUTRIENT CHOLINE DURING PREGNANCY 'SUPER-CHARGES' CHILD'S BRAIN FOR LIFE...
  108. Millions not getting key vitamins leading to diminished brain power...
  109. Vitamin C treats Charcot-Marie-Tooth disease (CMT), the most common inherited peripheral neuropathy...bad link
  110. Common Nutrients Fed To Pregnant Mice Lowered the Offspring's Susceptibility to Obesity, Diabetes and Cancer...
    "For the first time ever, we have shown precisely how nutritional supplementation to the mother can permanently alter gene expression in her offspring without altering the genes themselves."
  111. Vitamin C is Nature's Perfect Statin
  112. VITAMIN C REVERSES OSTEOPOROSIS IN MICE...
  113. STUDY LINKS LEAD EXPOSURE WITH 46% INCREASED RATE OF MORTALITY FROM ALL CAUSES - VITAMIN C CHELATES LEAD
    "Goyer and Cherian (1979) addressed the treatment of lead toxicity in rats. They found that orally administered vitamin C had a comparable ability to that of injected EDTA in the removal of lead from the animals, with equivalent amounts of lead being excreted in the urine. These researchers established that the combination of vitamin C and EDTA was more than twice as effective as either agent alone in the removal of lead" - Thomas Levy, MD,JD
  114. Ames: High Dose Vitamins can Treat more then 50 Genetic Disorders Common thread discovered.
  115. Vitamin C Does Not Cause Kidney Stones!!! Fourteen Year Study of 85,557 implicates low vitamin B6, exonerates Vitamin C.
  116. Why the Vitamin C Foundation Does Not Recommend Ester-C®
  117. Fluoride Accumulates in Pineal Gland...
  118. MS risk lower among men and women with higher vitamin D levels...bad link
  119. BREAST CANCER: Rates drop dramatically as women stop taking HRT...
    HRT implies common medical practice, e.g. estrogen-only, NOT bioidentical (.e. pharmaceutical) replacement. The right-HRT will not induce breast cancer caused by estrogen dominance. The right-HRT is bioidentical HRT, including natural progesterone.
  120. DRUG COMPANY INFLUENCE: Top scientist never disclosed payments from Pfizer...
  121. BANNED AND FINED: The price of selling apricot seeds (and extra virgin olive oil)...
  122. A TYPICAL DECEPTION: New antipsychotics are more expensive, but no more effective...
  123. Hamburg court dismisses proceedings against Dr Rath...
    How many of us knew that Dr. Rath was fighting in a German court over his right to publish the health benefits of vitamins? We didn't.
  124. Europe Debates Controls on Vitamin Supplements...
  125. USDA Attempts to Pack Organic Standards Board With Corporate Agribusiness Reps: Organic Consumers Fight Hijacked Seats on NOSB...
  126. Harvard: Sunshine, Vitamin D Prevents Influenza...
    "They call this "a provocative new hypothesis"... he he he
  127. Depression: It's just a vitamin B12 deficiency...
    Outrage: Local health authority banned doctor from giving harmless vitamin injections.
  128. Codex Chairman Seeks to Thwart Natural Solutions Foundation Pro Health Codex Initiative...
  129. A BOMBSHELL DROPS ON CHOLESTEROL MEDICATION'S GLASS HOUSE...
    "Current clinical evidence does not demonstrate that titrating lipid therapy to achieve proposed low LDL cholesterol levels is beneficial or safe."- Annals of Internal Medicine
  130. Antidepressants: They Make Everyone Suicidal...
  131. Government Investigation Finds Autism Vaccine Related...
  132. Canned tuna imports contain high levels of mercury...
  133. Serum magnesium levels lower in diabetic patients...bad link
  134. Folic acid supplements boost DNA repair...
  135. Omega-3s help depressive kids - pilot study...
  136. Silibinin (from Milk Thistle) helps prevent or slow lung cancer development...bad link
  137. Prostate cancer prevented with selenium accumulation in prostate tissue ...
  138. Intestinal surgery ups vitamin A deficiency...bad link
  139. Inositol compounds prevent Alzheimer's disease in mouse model...bad link
  140. Folic acid helps prevent certain throat cancers ...
  141. Vitamin K supplements reduce bone-loss...bad link
  142. California Bans Vaccines with Hazardous Mercury-Based Preservative Thimersoral for Young Children & Pregnant Women...
  143. Melatonin found in wine grapes ...
  144. Researchers report low plasma vitamin C levels predict adverse cardiovascular events in End Stage Renal Disease (ESRD) patients...
  145. Study Links Low Selenium Levels With Higher Risk Of Osteoarthritis...bad link
  146. Research shows influence of vitamin C on weight control...
  147. Myocardial ischaemia in a child infected with influenza B...Flu patients should be given the Pauling therapy
  148. Predictors of coronary artery disease in the Lebanese population...
  149. Lipoprotein(a), apolipoprotein(a) polymorphism and coronary atherosclerosis severity in type 2 diabetic patients...
  150. Prospective Study of Lipoprotein(a) as a Risk Factor for Deteriorating Renal Function in Type 2 Diabetic Patients ...
  151. Relationship between serum lipoprotein(a) concentrations and coronary vasomotion in coronary spastic angina...
  152. Orthomolecular oncology review: ascorbic acid and cancer 25 years later. ..
  153. Efficacy and safety of vitamin C vaginal tablets in the treatment of non-specific vaginitis. A randomized, double blind, placebo-controlled study...
  154. Vitamin C Supplementation and Respiratory Infections: a Systematic Review...
  155. The mystery of the wooden leg: vitamin C deficiency in East African prisons ...
  156. Anti-oxidant combo stops omega-3 degradation ...
  157. Oral vitamin C administration reduces early recurrence rates after electrical cardio version of persistent atrial fibrillation and attenuates associated inflammation...
  158. Serum concentration of lipoprotein(a) decreases on treatment with hydrosoluble coenzyme Q10 in patients with coronary artery disease: discovery of a new role...
  159. Myocardial metabolism and improved outcomes through carnitine, coenzyme Q10, and taurine supplementation after high risk heart surgery...
  160. Green Tea shows protective affect against autoimmune disorders ...
  161. Lipoprotein oxidation profile in end stage renal disease patients. Role of vitamin C supplementation...
  162. Ascorbic acid (vitamin C) supplementation and regular consumption of fresh orange juice increase the ascorbic acid content of human milk...
  163. Four in 10 mothers 'need vitamin pills' ...bad link
  164. Vitamin A's role in influencing symmetry during embryonic development revealed, a paradox...
  165. Vitamin C reduces risk of pregnancy complication...
  166. High magnesium linked with reduced mortality over an eighteen year period...bad link
  167. CoQ10 probably protects against Alzheimer's...
  168. Omega-3 and -6 fatty acids and vitamin E slashes the risk of motor neurone disease (MND) by 60 per cent...
  169. Just one day of breastfeeding boosts a baby's health...
  170. JAMA Meta-analysis concludes vitamin D supplementation lowers fracture risk ...bad link
  171. Silicon May Help Prevent Alzheimer's ...
  172. Scientists Unlock Puzzle of Vitamin A's Anti-Cancer Effects...
  173. The (World-Wide) Mortality Rate of Children Not Taking Vitamin A is Four Times Higher Than Those Who Have Taken It...bad link
  174. Increased intake of vitamin A precursor, beta-carotene, found naturally in carrots, broccoli and tomatoes, prevents the loss of lung function due to aging....
    The researchers, from the University of Medicine Bichat, Paris, also report that heavy smokers who had high intakes of beta-carotene and vitamin E reduced their loss of lung function.
  175. Food Mineral levels Declining...bad link
  176. Vitamins help to slow eye disease ...
  177. Vitamins E and C Confirmed Safe...
  178. Vitamins E and C are safe across a broad range of intakes ...bad link
  179. Vitamin E prevents Alzheimer's in combination with vitamin C, but not alone...
  180. Antioxidant-rich diets reduce brain damage from stroke in rats...
  181. Vitamin E found to reduce period pain ...
  182. Dietary Oils Work Quickly to Improve Cardiac Function ...bad link
  183. Lipids beat Lipid-lowering drugs for lowering mortality risk...bad link
  184. Vitamin C Reduces the Risk of Stomach Cancer in those infected with H. Pylori...
  185. Antitumor Effect of a Combination of Lysine, Proline, Arginine, Ascorbic Acid (Vit. C), and Green Tea Extract on Pancreatic Cancer ...
  186. In vivo antitumor effect of ascorbic acid, lysine, proline and green tea extract on human prostate cancer ...
  187. Musculoskeletal manifestations of scurvy...
  188. Studies of Vitamins and Minerals and HIV Transmission and Disease Progression...
  189. Vitamins C and E reduce retinal oxidative stress and nitric oxide metabolites and prevent ultrastructural alterations in porcine hypercholesterolemia...
  190. AMA journal says vitamin E preventive benefit in macular degeneration outweighs possible risks...bad link
  191. Lack of Vitamin C Linked to Respiratory Disorders ...
  192. Vitamin C not culprit with kidney stones ...
  193. Vitamin D Lowers Risk of Multiple Sclerosis ...
  194. Diagnosis: Subclinical Hypovitaminosis C...bad link
  195. Intravenous iron preparations and ascorbic acid: Effects on chelatable and bioavailable iron...
  196. Higher tissue zinc levels protect against esophageal cancer...bad link
  197. Vitamin A produces astonishing leukemia cure rate, even without chemotherapy...
  198. Pregnant women should take vitamin D supplements to protect their offspring from multiple sclerosis...
  199. How Vitamin C Fights Cancer...bad link
  200. Vitamin C Effective Against Common Feminine Problem...
  201. Vitamin C treatment reduces transcapillary escape rate of albumin in type 1 diabetes...
  202. Alternative Medicine: Fortifying Yourself with Vitamin C...
  203. Breakthrough in Vitamin C synthesis... Just in time?
  204. Vitamin C Deficiency, Iron Overload and Alcohol Abuse Underlie the Severe Osteoporosis in Black African Patients with Hip Fractures ...
  205. Ascorbic acid recycling by cultured beta cells: effects of increased glucose metabolism...
  206. Suppository chelation therapy (+vitamin C/lysine and other support) reverses calcification in coronary artery disease ...
  207. Topically applied vitamin C increases the density of dermal papillae in aged human skin...
  208. Requirement and criteria of adequate vitamin supply in healthy newborns...
  209. Production of L-Ascorbic Acid (vitamin C) by Metabolically Engineered Saccharomyces cerevisiae and Zygosaccharomyces bailii...
  210. Lack of Vitamin C Linked to Respiratory Disorders...
  211. Using Vitamin C Topically to Protect from UV Light...
  212. Relation Between Serum Lipoprotein (a) and Residual Lesion Stenosis of Coronary Artery After Myocardial Infarction Without Reperfusion Therapy...bad link [PubMed]
  213. Study Shows Vitamins C And E Can Prevent Metabolic Damage In Extreme Exercise
  214. Concern Unfounded About Damage From Vitamin C...
  215. Mercury From Dental Amalgams is the Cause of 80-90% of Alzheimer'sbad link - John Ely, Ph.D.
  216. MERCURY TOXICITY & DISEASES, ALZHEIMER'S DISEASE, DEMENTIA
  217. There is a possible role for vitamin K2 in the prevention of hepatocellular carcinoma in women with viral cirrhosis...bad link
  218. Arizona State University Researchers Find Scurvy Is Serious Health Problem ...
  219. Combination of TRISENOX(R), Vitamin C and Low-Dose Melphalan Produces 54 Percent Objective Response Rate in Late-Stage Multiple Myeloma Patients...bad link
  220. Improved nutrition could prevent more than half of the world's child deaths...
  221. Subjects with the lowest alpha-carotene, beta-carotene and lycopene levels had the highest risk of ischemic stroke...bad link
  222. Study: Supplements Halt Progression of Early Coronary Atherosclerosis Documented by Ultrafast Computed Tomography...
  223. EXERCISE FAILS TO SLOW ATHEROSCLEROSIS PROGRESSION IN MEN TAKING STATINS...bad link
  224. High antioxidant vitamin intakes reduce adverse effects of chemotherapy in children with acute lymphoblastic leukemia...
  225. Iodine deficiency causes permanent brain damage ...bad link
  226. CARDIOLOGISTS OVERLOOK LIFESAVING CO-Q10 DISCOVERIES...
  227. Antioxidants prevent birth defects...bad link
  228. Infantile Scurvy Rate of childhood strokes has doubled: study...bad link
  229. Nobelist Ignarro USC study finds supplements may prevent atherosclerosis ...bad link
  230. Reevaluation of ascorbate (Vitamin C) in Cancer Treatment...bad link
  231. Manipulation of L-ascorbic acid (LAA) to extremes in the treatment of acute myeloid leukemi...bad link
  232. Intragenic deletion in the gene encoding L-gulonolactone oxidase causes vitamin C deficiency in pigs...
  233. How Vitamin C Is Administered Affects How Much Reaches the Bloodstream and May Affect the Results of Studies of Its Potential Effect on Cancer ...bad link
  234. Vitamin C reduces levels of C-reactive protein...
  235. Influence of maternal serum levels of vitamins C and E during the second trimester on birth weight and length...
  236. Vitamin C: basic metabolism and its function as an index of oxidative stress...
  237. The protective effects of ascorbic acid on arterial haemodynamics during acute hyperglycaemia...
  238. Pernicious anemia: presentations mimicking acute leukemia...
  239. Frequent sex helps prevent prostate cancer...
  240. Boosting vitamin D levels may help prevent breast cancer, study suggests...bad link
  241. Zinc supplements could help treat ADHD...bad link
  242. Effect of ascorbic acid on plasma cholesterol in humans in a long-term experiment...
  243. Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use
  244. Vitamin D Lowers Risk of Multiple Sclerosis
  245. Taking a folic acid supplement stops the onset of migraines...
  246. LOOK HERE!!!!!
  247. Vitamins reduce risk for congenital anomalies other than neural tube defects...bad link
  248. Is Low Dietary Intake of Omega-3 Fatty Acids Associated With Depression? ..
  249. Zinc speeds recovery from pneumonia in boys...
  250. Reduced vitamin B12 levels correlate with poor memory in those at risk for Alzheimer's disease...bad link
  251. In the present study, we demonstrate for the first time that there is a significant increase in ATP synthetic capacity in lymphocytes from patients undergoing CoQ10 treatment...
  252. Vitamin C and selenium reduce alcohol induced hyperlipidemia in male guinea pigs...
  253. Medicine in the USA Kills Almost 1 Million Yearly...bad link
    "Recent attacks aimed at natural medicine prompted an independent review of government-approved medicine, which revealed that conventional medicine was the leading cause of death in the United States.

    This review of government health statistics showed that in most cases, American medicine does more harm than good. Compelling evidence from this study unveiled astounding statistics on the 783,936 deaths per year that have resulted from conventional medicine."

  254. Paracetamol linked to asthma...
    Women who took the drug for more than 14 days per month were 63% more likely to develop asthma.
  255. Combination therapy with vitamins C plus E inhibits human prostate cancer cell growth...
  256. Antioxidant intervention blunts renal injury ...
  257. Vitamin E useful in the management of transfusion-dependent Ebeta- and beta-thalassemia patients...
  258. Nutritional Supplements Historical Background...bad link
  259. Early Vitamin E Supplements Stem Development Of Hallmark Alzheimer's Symptoms In Mice...bad link
  260. Vitamin E Cuts Bladder Cancer Risk by 50%...
  261. Even low dosage antioxidants shown to have "significant" benefit in diabetics...
  262. Brain needs more vitamin C than any other part of the body...
  263. Vitamin deficiency of the B vitamins, vitamin E and even vitamin C, can adversely affect your memory...bad link
  264. Millions not getting key vitamins leading to diminished brain power...
  265. Vitamin C treats Charcot-Marie-Tooth disease (CMT), the most common inherited peripheral neuropathy...bad link
  266. New tumor cell strategy uses altered vitamin B-12 ...bad link
  267. Vitamin C Research: 'Important New Treatment of Respiratory Disorders'...bad link
  268. Lowered plasma vitamin C, but not vitamin E, concentrations in dementia patients...
  269. CLINICAL TRIAL: 5% VITAMIN C TOPICALLY IS AN EFFECTIVE SKIN ANTI-AGING/ANTI-WRINKLE TREATMENT...
  270. NUTRIENT CHOLINE DURING PREGNANCY 'SUPER-CHARGES' CHILD'S BRAIN FOR LIFE...
  271. Influence of l-arginine and vitamin C on the autonomic nervous system in chronic heart failure secondary to ischemic cardiomyopathy...
  272. LOOK HERE!!!!!
  273. Even 'vitamin-like' supplementation with combination of vitamin E and vitamin C slows atherosclerosis...
  274. U.N. Researchers said they could predict 62 percent of heart disease deaths by looking at blood levels of vitamin E...
  275. BASAL CARCINOMA CURE (skin cancer) - VITAMIN C SOLUTION...
  276. Reducing TB With Light...
  277. Vitamin E reduces muscle soreness...
  278. IRON DEFICIENCY LEADS TO HAIR LOSS...
  279. Topical vitamin C is the latest rage in anti-wrinkle products...
  280. Opposition to naming a middle school after Linus Pauling...bad link
  281. Bones of St. Croix Island tell tale of suffering at Champlain settlement...bad link
    An archaeologist says many of the bones recovered on the island, now an international historic site, bear the unmistakable scars of scurvy, a fatal condition caused by lack of vitamin C in the diet.
  282. Vitamin C inhibits HMG-CoA reductase in humans...
  283. A Simple Preventive and Therapy for Cardiovascular Disease (CVD)...
  284. Vitamin C helps neutralize toxins in CA state park...
    "Once again, the Berkeley Skate Park is ailing, and the cure could be something that's in everyone's medicine cabinet -- vitamin C. Marc Seleznow, acting director of Berkeley's Parks, Recreation and Waterfront Commission, said vitamin C helps neutralize the toxic substance chrome 6, which was first detected at the park at Fifth and Harrison streets near Interstate 80 three years ago. Vitamin C, technically known as ascorbic acid, is sprayed into cracks and brushed in, he said. "
  285. Genotoxic effects of a complex mixture adsorbed onto ambient air particles on human cells in vitro; the effects of Vitamins E and C...
  286. Effect of ascorbate on serum lipids and urate metabolism during exhaustive training...
  287. Vitamin C prevents cigarette smoke-induced oxidative damage in vivo...
  288. Some swear by intravenous vitamin therapy...bad link (Link to the 'Myers Cocktail')bad link
  289. Scurvy in children...
  290. Research: Vitamin E, vitamin C improves fibrosis...
  291. Vitamin A cures lung disease emphysem in mice... Vitamin C pills protect the heart...bad link
  292. A diet rich in Vitamin C can help lower the risk of stroke...
  293. Vitamin C reduces allergy symptoms...bad link
  294. VITAMIN C HALTS STOMACH AILMENTS...bad link
  295. Improvement of peripheral endothelial dysfunction by acute vitamin C application...
  296. PRECURSOR TO HEART DISEASE - OXIDATIVE ARTERIOLAR WALL SHEAR STRESS - IS PREVENTED BY CHRONIC VITAMIN-C TREATMENT...
  297. LOW PLASMA VITAMIN C IS ASSOCIATED WITH INCREASED RISK OF STROKE...
  298. LONG-TERM USE OF VITAMIN C AND E SUPPLEMENTS HELP TO MAINTAIN COGNITIVE FUNCTION...bad link
  299. "A study done on 1,000 Finnish men demonstrated that men with low vitamin E levels in their serum were almost 400 percent more vulnerable to develop diabetes."
  300. Elderly falls linked to vitamin-D deficiency ...
  301. The Use of Vitamin C as an Adjuvant Therapy to Recombinant Human Erythropoietin in Patients with End-Stage Renal Disease...
  302. Vitamin C and Vitamin E in Prevention of Nonalcoholic Fatty Liver Disease ...
  303. Therapeutic efficacy of high-dose vitamin C on acute pancreatitis and its potential mechanisms...
  304. High Doses of Antioxidants Including Vitamin C Do Not Decrease the Efficacy of Chemotherapy...
  305. Ascorbic Acid: a promising memory-enhancer in mice...
  306. UK: New Treatment for Osteoporosis Found, 20,000 mg vitamin C...bad link
  307. Protective effect of vitamin C against the ethanol mediated toxic effects on human brain glial cells....
  308. Top 10 Vitamins for better health...bad link
  309. Vitamin C treatment reduces Huntington disease symptoms in mice ...
  310. Antioxidant Vitamins C and E Prevent Certain Complications of Surgery...bad link
  311. Serum concentration of lipoprotein(a) decreases on treatment with hydrosoluble coenzyme Q10 in patients with coronary artery disease: discovery of a new role...
  312. THE CANCER COVER-UP...bad link
  313. Antioxidant Vitamins C and E Improve Endothelial Function in Children With Hyperlipidemia...
  314. Role of ascorbic acid in the modulation of inhibition of platelet aggregation by polymorphonuclear leukocytes...
  315. The Effect of Ascorbate on Serum Lipids and Urate Metabolism During Exhaustive Training
  316. Exercise-induced endotoxemia: the effect of ascorbic acid supplementation
  317. Role of ascorbate in oxidative protein folding
  318. Plasma Vitamin C is associated with gray matter volume determined by MRI in non-demented old people...
  319. Vitamin Cuts Second-hand Smoke Damage...
  320. Effects of high dose vitamin C treatment on Helicobacter pylori infection and total vitamin C concentration in gastric juice...
  321. Harvard: Vitamin C Reduces Risk of Heart Disease...bad link
  322. Correlation Between Helicobacter pylori Infection and Vitamin C Levels in Whole Blood, Plasma, and Gastric Juice, and the pH of Gastric Juice...
  323. The effect of 5-year vitamin C supplementation on serum pepsinogen level and Helicobacter pylori infection...
  324. Topical ascorbic acid (vitamin C) on photoaged skin...
  325. Vitamin C treatment attenuates the Huntington behavioral phenotype in mice...
  326. Magnesium supplementation decreases oxidative stress in diabetic rats ...
  327. Low vitamin C increases the risks of developing inflammatory arthritis...
  328. Vitamin K can lessen bruising...
  329. MECHANISM OF ACTION FOUND FOR VITAMIN C AGAINST CANCER...
  330. Vitamin C helps drugs cross blood brain barrier...
  331. Vitamin C Transforms Mouse Stem Cells Into Heart Muscle Cells...
  332. Vitamin C Boosts Immune System in as Little as 5 hours.
  333. Independent consumer lab rates vitamin C products, quality improving...
  334. Hypothesis: vitamin C is superior to diltiazem for radial artery vasodilation in patients awaiting coronary artery bypass grafting
  335. BULLETIN: Researchers admit vitamin C/E data does not support claim that these antioxidants increase mortality...
  336. MORE BAD SCIENCE: Bogus study makes news... Why and where do such false reports come from?bad link
  337. Novel Vitamin C use
    High-dose ascorbic acid increases intercourse frequency and improves mood: a randomized controlled clinical trial.
  338. JAMA study inadvertently proves Vitamin C and Magnesium benefits for cardiovascular patients... and More on the questionable use of placebos in medical trials...bad link
  339. Vitamin C treatment for snake bites in dogs...
  340. Multivitamins 'cut birth defects' BBC
  341. Reevaluation of ascorbate in cancer treatment recommended
    "We propose that ascorbate treatment of cancer should be reexamined with rigorous scientific scrutiny in the light of new evidence."
  342. Effects of oral vitamin C on monocyte: endothelial cell adhesion in healthy subjects
  343. Even mild vitamin C deficiency impairs vascular function...
  344. Plasma Vitamin C Modifies the Association Between Hypertension and Risk of Stroke.
  345. Vitamin C prevents hyperoxia-mediated vasoconstriction and impairment of endothelium-dependent vasodilation.
  346. Low vitamin C consumption may be linked to a serious complication of pregnancy called pre-eclampsiabad link
  347. Low VITAMIN C more than doubles stroke risk
  348. Vitamin C benefits in Heart Disease after high fat meals
  349. Study links low vitamin C levels to heart attack and stroke
  350. New Study: Vitamin C Beneficial for Lung Health
  351. Taking vitamins C and E could slow the progress of a potentially fatal cardiovascular condition in heart transplant patients, scientists suggest.
  352. Vitamin C Proven to Prevent Gallstones
  353. Fourteen Year Study of 85,557 Confirms Vitamin C Does Not Cause Kidney Stones!!!
  354. Vitamins Reduce Pregnancy Danger
    Pregnant women at risk of the potentially deadly condition pre-eclampsia appear to benefit from doses of vitamins C and E, research says.
  355. Proposed laws supported by pharmaceutical companies would severely restrict the public's access to vitaminsbad link
    To date 604 million Europeans have signed the largest global on-line petition ever.
  356. Vitamin C Transporter Gene Discovery In Mice Suggests Possible Role for Ascorbic Acid in Preventing Life-threatening Complications Seen in Premature Infants
    NIH National Genome Research Institute: "Low Vitamin C Could Be Linked to Massive Brain Bleeding and Lung Failure in Premature Newborns."
  357. More then 50 genetic disorders now understood that can be successfully treated with high-dose vitamins" Bruce Ames in Amer. J. of Clinical Nutrition.
  358. Hemorrhage associated with vitamin C deficiency in surgical patients
    Show this paper to your doctor before scheduled surgery.
  359. Study confirms that circulating vitamin C levels differ from tissue levels.
  360. Long-term study shows safety of daily high-dose vitamin A.
    No clinical symptoms or signs of liver toxicity attributable to vitamin A excess were detected. Five to seven years.

    **** Vitamin A, a medical Erroneous zonebad link by Don Davis, an associate of the late Roger J. Williams.

  361. Vitamin C Cancer Benefits Amazing anecdotal report.
  362. Study claims that the vitamin C content of popular ready-to-drink brands of orange juice can drop from 45 mg per cup to zero within four weeks after opening
  363. More vitamin C and beta-carotene, less meat, means longer life for smokers
  364. Sloan-Kettering Admits Vitamin C PROTECTS Against DNA Damage
  365. New Study: Vitamin C and Vitamin E Prevent Atherosclersosis
  366. Vitamin C, H. Pylori and stomach cancer
  367. Explaining Just How Vitamin C Works Against Cancer
  368. Adding Vitamin C to some Drugs May help Alzheimer's Patients
  369. Vitamin C Found To Inhibit Congestive Heart Failure
  370. Vitamin C Cuts Cold Symptoms 85%
  371. Read the Debate on whether Garlic provides anti-bacterial protection against Anthrax! This is the way science is supposed to work.
  372. Animal-Based Nutrients Linked With Higher Risk Of Stomach And Esophageal Cancers Vitamin C supplements reduce stomach cancer by 40% "We also found that regular users of vitamin C supplements were at significantly lower risk of stomach cancer"
  373. High dose Vitamin C and Iron does NOT damage DNA Says recent study that was designed to find out.
  374. Vitamin C Derivative Prevents Stroke Damage in Mice
  375. STUDY MIS-CHARACTERIZES ROLE OF ANTIOXIDANTS IN BLOOD VESSEL DISEASE
  376. Are Vitamin C and Vitamin E Bad for Heart Patients? Who should we believe: August 8th news report, or Linus Pauling?
  377. Vitamin C T-Shirts from Japan
  378. Protective action of vitamin C against DNA damage induced by selenium-cisplatin conjugate.
  379. Comparison of nitric oxide-releasing NSAID and vitamin C with classic NSAID in healing of chronic gastric ulcers
  380. Cambridge Medical School Researchers Report (Mar 2001): Even Minuscule Increases in Blood Vitamin C Levels Result in Great Decreases in Death from All Conditions Two recent independent studies give similar results, yet these peer-reviewed, published papers did not make news!?
  381. Vitamins Prevent Stomach CancerNotice that some participants received 2,000 milligrams per day of vitamin C, the same "mega-doses" that just last year we were warned might cause tumors to grow explosively. In reality, they made these pre-cancerous stomach lesions shrink.
  382. Is Vitamin C Risky? plus our rebuttal to recent Media terror attacks.
  383. Young having more Heart Attacks. Pauling explained why Children need more vitamin C.
  384. Headline: New life for vitamin C as cancer treatment: Articles say early studies of its value were prejudiced
  385. Vitamin C May Prevent Coronary Artery Disease (Feb 01)
  386. FDA attempting to regulate maximum vitamin limits (Dec 00)
  387. Genetically engineered mice implicate vitamin C deficiency in heart disease More evidence supporting the Pauling/Rath heart disease theory.
  388. Doctors strike In Israel good for health The real story behind the new wave of prescription drug advertising.
  389. Life Extension doctors check USC "artery clogging" results LEF scientists look for carotid artery thickening in high-dose vitamin C users - and fail!
    "The results of The Life Extension Foundation's four-pronged carotid ultrasound test showed that in 23 out of 30 of these very high vitamin C supplement takers, there was no evidence of carotid plaque formation, obstruction (stenosis) or intimamedia thickening. Blood flow velocity through the carotids was completely normal in these 23 subjects.

    "If we had set a cutoff of 60 years of age as the American Heart Association did, we would have found that none of our test subjects would have shown clinically significant carotid artery pathology. In other words, had we used the same narrow parameters (under age 60) that were presented at the American Heart Association meeting, we would have had no carotid artery pathology to report in this group of people who take very high doses of supplements."

  390. Is vitamin C Risky? Politics versus Science. The new RDA ignores the science.
  391. "A crime against our society" Lawsuit to be Filed Against National Academy of Sciences Jay Patrick charges US National Academy of Science with "absolute falsehoods" regarding the use of high intakes of vitamin C, vitamin E and selenium.
  392. RDA Increased! [Editorial] Bowing to public pressure, the National Academy of Sciences has increased the Vitamin C Recommended Daily Allowance (RDA) by 50% from 60 mg to 75-90 mg, more for smokers. RDA for vitamin E also raised. [RDA Press Release]bad link
  393. Liver Detoxification Vitamin C countered Tylenol poisoning.
  394. Low Vitamin C Levels Linked to Increase in Gallbladder Disease Large study confirms 1950s research.
  395. Vitamin C, E Protect the Aging Brain Elderly men who took vitamin E and C supplements were protected from dementia and showed improvements in cognitive function.
  396. Oral vitamin C supplementation proven to benefit arteries. Researchers say ascorbate may be an effective therapy in cardiovascular disease.
  397. Vitamin C with vitamin K3 causes "new kind" of cancer cell death. from Ralph Moss's cancerdecisions.com
  398. Vitamin C lowers lead levels in blood. Especially in children.
  399. JAMA and others urge increase in RDA of vitamin C
  400. NIH Team: Vitamin C could be an approach to tackling antibiotic resistant bacteria
  401. Antioxidant Vitamin C helps heart and circulation by enhancing cell production of nitric oxide (NO) a free radical!
  402. Vitamin C may reduce risk of cataract development
  403. New research on vitamin C and tooth decay supports decades old reports that 6 gm vitamin C provides 100% protection against tooth cavities.
  404. Vitamin C a polio cure. Note: This paper was published in 1949!
  405. The Linus Pauling/Matthias Rath Unified Theory of Human Cardiovascular Diseasebad link On-line paper published in the J. of Orthomolecular Medicine.
  406. The early Willis vitamin C and atherosclersosis studies

    Other News

  407. How did Flu Remedy Relenza make it past the FDA?bad link From Newsmax.com
  408. Feds want Big Brother (aka FDA) to regulate internetbad link
  409. Evidence of Research Fraud in Magnesium Studybad link
  410. Vitamin E Safe, Contrary to Recent Press Reports
  411. Finnish Beta Carotene Study - The Untold Story
  412. Selenium Protects Against Prostate Cancer Large Study shows major benefit of Selenium
  413. Growth Hormone Replacement Therapy
    "THE MOST COST EFFECTIVE ANTI-AGING STRATEGY IS TO TAKE A SPECTRUM OF HIGH POTENCY VITAMINS, MINERALS, AND TRACE ELEMENTS, INCLUDING THE ANTI-OXIDANTS. RECENT MEDICAL RESEARCH IN MAINSTREAM JOURNALS DOCUMENTS CLOSE TO 50% REDUCTION IN CANCER AND CARDIOVASCULAR DISEASE BY MERELY TAKING SUPPLEMENTS FAR MORE POTENT THAT THE RDAs. SINCE CANCER AND CARDIOVASCULAR DISEASE CAUSE 75% OF DEATHS AND DISABILITIES WITH AGING, THAT IS VERY IMPORTANT. AGING CAN TO SOME EXTENT BE LOOKED ON AS A DEFICIENCY OF MICRONUTRIENTS." [Dr. Elmore Cranton]
  414. Discovery: New DNA type that conforms to the "incorrect" Pauling triple-strand model
  415. JAMA Androstenedione study - a critique
  416. BASF to close down vitamin C production...
  417. Antioxidants Proven To Be Key To A Longer and Healthier Life...
  418. Codex Alimentarius: No Emphasis On Nutrients...
  419. The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. ...
  420. The High Atherosclerotic Risk Among Epileptics: the Atheroprotective Role of Multivitamins....
  421. Athletes: Amino Acids Speed Muscle Recovery...
  422. Acid Blockers Also Block Calcium...
  423. JAMA says doctors should stop accepting bribes from drug companies...
  424. Feds Raid Supplement Maker...bad link
  425. CODEX: World Trade Organization ruling on GM foods signals danger for DSHEA...
  426. Low fat diet 'has no effect on heart risk'...
  427. Lower colon cancer risk for women with high magnesium intake...bad link
  428. Arthritis Suffering Effectively Treated With Digestive Enzyme Supplements...
  429. Vitamin E and selenium reduce mercury toxicity in animal model...
  430. Cough-medicine alert silences the quack watchers...bad link
  431. Australia: "Half our children deprived of iodine"...bad link
  432. Low cholesterol levels in the eyes raise cataract risk...
  433. Calls to boost vitamin B12 RDA...
  434. Citizens For Health Endorses Health Freedom Protection Act...
  435. New Study Finds Cranberry Compounds Block Cancer-First Study to Confirm Cranberry Proanthocyanidins Inhibit Growth of Tumor Cells ...
  436. Vitamin A May Prevent, Treat Lung Cancer...bad link
  437. Review Casts Doubt on Soy Health Benefits ...
  438. Apple juice may protect memory in old age...
  439. Alternative Medicine Shown to Work...bad link
  440. Drug error, not chelation therapy, killed boy, CDC expert says...
  441. Lack of vitamin B1 found in heart patients...bad link
  442. Chromium supplementation extends rat lifespan...bad link
  443. Children Poisoned by Medications a Common Cause of ER Visits ...
  444. Accidental Acetaminophen (Tylenol ) Poisonings Rise ...
    Over six years, researchers tracked 662 consecutive patients in acute liver failure who were treated at 22 transplant centers. (Acute liver failure is the most severe type, developing over days, unlike chronic liver failure that can simmer for years because of alcohol abuse or viral hepatitis.)

    Almost half were acetaminophen-related. More remarkable was the steady increase: Acetaminophen was to blame for 28 percent of the liver poisonings in 1998, but caused 51 percent of cases in 2003.

    That makes acetaminophen the most common cause of acute liver failure, the researchers report in the journal Hepatology.

    While most patients pulled through with intensive care, 74 died and 23 others received a transplant.

  445. Low LDL Increases Death Risk...bad link (Requires Login)
    Mortality Risk Drops With Increasing LDL Cholesterol in Elderly Women A new study of elderly men and women shows that higher LDL cholesterol levels are associated with decreasing total mortality risk in women. The risk of fatal heart failure decreases with higher LDL cholesterol levels in both genders.
  446. Low-fat diet study claims to 'reverse' diabetes...
    Researchers from UCLA have claimed that a three-week high-fiber, low-fat diet can reverse type-2 diabetes and metabolic syndrome (MetS) — conclusions that go against medical understanding of the conditions.
  447. But not Thomas Smith's findings (See: www.healingmatters.com)
    A low-fat diet is also a low/no trans-fat diet.

    Also see The Vitamin C Connection to Type-2 Diabetes

  448. Aspirin for Heart Patients: Not As Safe As Believed...
  449. Nutrient Supplementation Reduces Irregular Heartbeat (Arrhythmia) in Patients...bad link
  450. High Insulin Levels Linked to Pancreatic Cancer ...
  451. Researchers link vitamin D to healthier lungs...
  452. Micronutrients Boost Life Quality for Elderly with Heart Failure...
  453. Omega-3 Fatty Acids Help Decrease Postpartum Depression - study...
  454. Selenium supplements needed for elderly women, say researchers...
  455. Folate supplements could improve immune system in the elderly...
  456. Women Are Missing the Folic Acid Message...bad link Vitamin A fortification campaign launched...bad link
  457. Drug Lobby Hopes to Make Clinical Trial of Vitamins Illegal in South Africa...
    ""We are launching the court action and demand that the health minister should stop Matthias Rath's (a German distributor) illegal activities which include conducting illegal clinical trials," said Treatment Action Campaign (TAC) secretary general Sipho Mthathi."
  458. H.R. 3156 Supplement Action Alert!bad link
    "Elected representatives Susan A. Davis (CALIF), John D. Dingell (MICH) and Henry A. Waxman (CALIF) have introduced legislation [HR 3156] before the House of Representatives, now in committee, that would virtually destroy the dietary supplement industry." - Bill Sardi
  459. Global Vitamin Guidelines One Step Closer to Restricting Consumer Health Freedom...bad link
  460. Aspirin doubles risks of death after brain hemorrhage ...bad link
    Certain drugs, such as aspirin, cortisone, and other anti-inflammatory agents, and cinchophen, are known to provoke ulcers and gastric hemorrhage. This is especially the case when a deficiency of ascorbic acid is present. In animal experiments, the administration of ascorbic acid along with the toxic drug reduced the incidence of peptic ulcer and gastric hemorrhage to such an extent that it prompted one author (Aron) to suggest, "Therefore it would seem judicious in human therapeutics to include ascorbic acid in every prescription for an anti-inflammatory drug" [ Healing Factor by Stone ]
  461. Avian Influenza: Are You Prepared?
    Various U.S. and U.N. agencies and the Council on Foreign Relations are spreading the word that the Avian Influenza, if it breaks out this fall or winter, could be as severe as the worldwide Spanish Influenza epidemic of 1918, and they are predicting hundreds of millions of deaths worldwide. This influenza, currently isolated in China, is a hemorrhagic illness. It kills half of its victims by rapidly depleting ascorbate (vitamin C) stores in the body, inducing scurvy and collapse of the arterial blood supply, causing internal hemorrhaging of the lungs and sinus cavities...
  462. Some Nutritional Supplements Use Hydrogenated Oils as Filler ...
  463. Gene-Altered Peas Scrapped in Australia After They Damaged Health of Lab Animals...
  464. Proanthocyanidins from cranberry inhibit tumor growthbad link
  465. Vitamin D Role in Prostate Cancer Prevention...bad link
  466. How Evening-Primrose Oil Fights Cancer...
  467. Vitamin D appears more important than high calcium for bones...
  468. Protein discovery could be clue to vitamin E's anti-cancer effect...
  469. Compounds in olive oil appear to protect against colon cancer...
  470. Vitamin (Biotin) can halve white line disease in dairy cows...bad link
  471. Tips for Reducing Vitamin B12 Deficiency...
  472. Why Flu Epidemics Occur in Winter ...bad link
  473. 'James Bond': Iodine deficiency life threatening...bad link
  474. Adults over 50 may have problems absorbing Vitamin B12... Stomach acid is required
  475. Daily dose of good bacteria cuts sick leave ...
  476. Older people need more vitamin D...
  477. Researchers Stop Diabetes Damage with High Doses of Vitamin Cbad link
    Researchers at the Harold Hamm Oklahoma Diabetes Center have found a way to stop the damage caused by Type 1 diabetes with the combination of insulin and a common vitamin found in most medicine cabinets.

    While neither therapy produced desired results when used alone, the combination of insulin to control blood sugar together with the use of Vitamin C, stopped blood vessel damage caused by the disease in patients with poor glucose control.

    "We had tested this theory on research models, but this is the first time anyone has shown the therapy's effectiveness in people," said Michael Ihnat, Ph.D., principal investigator and a pharmacologist at the OU College of Medicine Department of Cell Biology.

  478. 2011: Study of 232,007 Find Significantly Lower Risk of Diabetes Associated with the Use of Vitamin C Supplements
  479. Study: Vitamin C Shown to Help Type II Diabetics
  480. Nutritional Supplements (Esp. Vitamin C) Key to Preventing Diabetic Retinopathy (DR)
  481. Chinese make vitamin C Breakthrough that reportedly provides hope in preventing the onset of CVD and Type 2 diabetes.
  482. The Use of Vitamin C as an Antibiotic By Dr. Fred Klenner
  483. The Vitamin C Treatment of Whooping Cough
  484. Pharmacokinetics of vitamin C: Insights into the Oral and Intravenous Administration of Ascorbate.
    There is a strong advocacy movement for large doses of vitamin C. Some authors argue that the biological half-life for vitamin C at high plasma levels is about 30 minutes, but these reports are the subject of some controversy. NIH researchers established the current RDA based upon tests conducted 12 hours (24 half lives) after consumption. The dynamic flow model refutes the current low-dose recommendations for dietary intakes and links Pauling's mega-dose suggestions with other reported effects of massive doses of ascorbate for the treatment of disease.
  485. Efficacy of Vitamin C Vaginal Tablets in the Treatment of Bacterial Vaginosis: a Randomised, Double Blind, Placebo Controlled Clinical Trial.
  486. Rationale and impact of vitamin C in clinical nutrition...
    "In critically ill patients and after severe burns, the rapid restoration of depleted ascorbate levels with high-dose parenteral vitamin C may reduce circulatory shock, fluid requirements and oedema."
  487. A Randomized, Double-Blind, Placebo-Controlled Trial of Nutritional Supplementation During Acute Illness...
    Oral nutritional supplementation of acutely ill patients improved nutritional status and led to a statistically significant reduction in the number of non-elective readmissions.
  488. Intravenous Vitamin C Saves New Zealand Man with H1N1 Flu Damaged Lung (Story we posted last January)
  489. Segment 3: Levy's Discussion of Vitamin C Toxicity and Kidney Stones (Video)
  490. PUTTING THE "C" IN CURE: Quantity and Frequency are the Keys to Ascorbate Therapy
  491. VITAMIN C AS AN ANTIVIRAL: It's All About Dose
  492. VITAMIN C AND ACIDITY What Form is Best?
  493. Vitamin C Improves Resistant Anemia in hemodialysis (HD) Patients
  494. Vitamin C: A Life-saving Treatment for Sepsis
  495. Doctor's Report: VITAMIN C CURES SHINGLES [Herpes Zoster]
  496. Moderate Vitamin C Dose Enhances H. Pylori Eradication
  497. Intravenous Vitamin C Therapy Excellent technical reference on IVC.
  498. Ascorbic Acid Orally - Not for IV Sodium Ascorbate Only for IV Infusions.
  499. Great Article on "Swine Flu", Why We Are Hearing About it Now, and How to Protect Against it
  500. Dr. Cathcart on Great Value of High Vitamin C (ascorbate effect) Fighting Viral Infections
  501. Vitamin C deficiency increases the lung pathology of influenza virus-infected gulo-/- mice.
  502. Elevated levels of dietary ascorbic acid increase immune responses in channel catfish
  503. Vitamin C and immunity: an assessment of the evidence. (Mainstream Review)
    "The high concentration of ascorbate in leucocytes and its rapid expenditure during infection and phagocytosis suggests a role for the vitamin in the immune process. Evidence published to date shows an involvement in the migration and phagocytosis by macrophages and leucocytes, as well as the induction and expression of delayed hypersensitivity."


Hot Topics

  1. L-Carnitine Significantly Improves Patient Outcomes Following Heart Attack, Study Suggests
    Apr. 11, 2013 . L-carnitine significantly improves cardiac health in patients after a heart attack, say a multicenter team of investigators in a study published today in Mayo Clinic Proceedings. Their findings, based on analysis of key controlled trials, associate L-carnitine with significant reduction in death from all causes and a highly significant reduction in ventricular arrhythmias and anginal attacks following a heart attack, compared with placebo or control. http://www.sciencedaily.com/releases/2013/04/130412132321.htm

    In an odd coincidence, only 3 days prior to the release of the real Mayo Clinic study about carnitine, a story with the opposite information about carnitine was released, per this article in the Huffington post L-Carnitine, Nutrient In Red Meat, Linked With Heart Disease The first story was discussed by our forum at this topic

  2. Vitamin E intake significantly improve liver disease, Nonaloholic Steatohepatits (NASH), says study
  3. Adding Vitamin E to Contact Lenses "hundred times" more effective" treating glaucoma

Vitamin C Foundation

The Great Suppression

Owen's Book Volume II: The Great Suppression of American Alternative Medicine (online)

History Lesson

Pharma's Don't-Take-Vitamins Study Diametrically Opposed by Valid Study
"Ask yourself why vitamins (!) are suddenly an issue and who is behind it? As food is increasingly degraded, are you not aware how crucial supplementation for vital nutrients is? Are you aware that disease is an investment industry and this is in the service of it?

Huffington Post just published Women Who Take Vitamin Supplements May Have Increased Death Risk, at precisely the moment that the pharmaceutical industry is in health attack mode to limit access to nutritional supplements in the US. How coincidental!

The AMA, which is heavily funded by Pharma, put out a study purporting to show that vitamins are a threat to people.s lives..."

Help Fight Absurd FDA Action - Protect Your Access to Nutritional Supplements - Tell Congress to Call for Withdrawal of FDA NDI Guidance

FDA and Senator Dick Durbin(D)'s schemes to outlaw nearly all nutritional supplements created after 1994 would destroy millions of jobs and devastate economy

More:

Medical Science for Sale.

A recent study in the Journal of the American Medical Association found over 40 percent of the best designed, peer-reviewed scientific papers published in the world's top medical journals misrepresented the actual findings of the research. The "spin doctors" writing the papers found a way to show treatments worked, when in fact, they didn't.

Vitamin C Mega Dosing - Big Pharma suppresses an inexpensive powerful curea

Amazing Summary of Recent Vitamin E Research Ignored by the Media

Vitamin C research called "hog wash"

Torrential Feedback To Reader's Digest Anti-Vitamin Article

More Absurd FDA Action Against Vitamin C

In a time of budget cutting and deficits, the FDA somehow has the capacity to go after one of the safest substances known!
FDA also noted packaging materials place product names in close proximity to the words .Cold Remedy." Further, website claims at issue include .Extra boost of Vitamin C in every RapidMelt,".Extra boost of Vitamin C and Echinacea in every RapidMelt," .Reduces the duration of cold symptoms when taken at the first sign of a cold."

FDA said these statements about the RapidMelts Vitamin C products are intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in violation of section 201(g)(1)(B) of the Act (21 U.S.C. § 321(g)(1)(B)). Also, the statements say the products are intended to affect the structure or function of the body of man in violation of section 201(g)(1)(C) of the Act (21 U.S.C. § 321(g)(1)(C))

No Deaths from Vitamins - None at All in 27 Years Orthomolecular News Service

ACTION ALERT: The United States FDA versus Vitamin C

Deja vu at the FDA

"Now I find myself at odds once again with that underfunded, overworked and under appreciated defender of public safety responsible for protecting Americans from dangerous drugs. Despite all of these limitations, the FDA has somehow managed to find the resources to clamp down on vitamin C! Yes, ascorbic acid. Bottled sunshine. Probably the best studied, most researched and commonly used, plant based nutritional supplement known."
- Jonathan Barnet@resistanceisfruitful.com
FDA Position on Intravenous Vitamin C Limits Access, But Does Not Render Vitamin C-IV Unlawful Legal Opinion by Emord and Associates.

FDA Action Has Halted Trials of Vitamin C and Cancer!


Vitamin C Foundation

Other


Dr David Ayoub's Proof that Mercury Causes Autism


The Vitamin A and Vitamin D Controversy

Vitamin C Foundation The Cod Liver Oil Debate (from Weston-Price) Vitamin A is not a Vitamin D Antagonist.

Contrary to information from the Vitamin D Council, and most recently, from the Life Extension Foundation," Vitamins A and D cooperate with one another. They are not antagonists, but large doses of one may cause harm when not accompanied by the other."

Since vitamin A is required as a signaling partner with vitamin D, vitamin D will increase the turnover of vitamin A. If vitamin A is provided in excess, the results are generally beneficial. Excess vitamin A is stored in the liver. However, when the liver's storage capacity is exceeded, the overload of vitamin A causes the cells to burst, damaging the liver and releasing storage forms of vitamin A into the systemic circulation that do not belong there. By increasing the utilization of vitamin A, vitamin D can help prevent vitamin A toxicity.

If vitamin A is in short supply, on the other hand, the results can be detrimental. By .stealing. all of the vitamin A needed to use for vitamin D specific functions, the body will not have enough vitamin A left to support the many other functions for which it is needed.this may partially explain the toxic effects of excess vitamin D.



And now for something completely different

Dr. Marvin Antelman telephoned Owen frequently from Israel. During these calls, Dr. Antelman expressed interest in studying Pauling's vitamin C therapy in heart patients in Israel.

Unknown to Owen, at that time, was Dr. Antelman's history curing AIDS with the following invention.

Is patent 5,336,499 the general antidote for all bio warfare weapons? i.e. is it the cure for Lyme?

United States Patent 5,336,499
Antelman August 9, 1994
Molecular crystal device for pharmaceuticals

Abstract

A novel molecular scale device is described which is bactericidal,
fungicidal, viricidal and algicidal. The anti-pathogenic properties
of the device are attributed to electron activity indigenous to
diamagnetic semiconducting crystals of tetrasilver tetroxide (Ag.sub.4
O.sub.4) which contains two monovalent and two trivalent silver ions
in each molecular crystal. When the crystals are activated with an
oxidizing agent, they release electrons equivalent to 6.4.times.10.
sup.-19 watts per molecule which in effect electrocute pathogens.
A multitude of these devices are effective at such low concentrations
as 0.3 PPM used as preservatives in a variety of formulations ranging
from cosmetics to pharmaceuticals. Indeed, they are intended as active
ingredients for pharmaceuticals formulated to destroy such pathogens
as Staphylococcus aureus, and epidermidis, the latter of which it
completely destroys in a nutrient broth culture of about 1 million
organisms at 0.6 PPM, or Candida albercans, the vaginal yeast infection
at 2.5 PPM, and the AIDS virus at 18 PPM.
Inventors: Antelman; Marvin S. (Rehovot, IL)
Assignee:  Antelman Technologies, Ltd. (Providence, RI)
Appl. No.: 07/971,933
Filed:     November 5, 1992



Vitamin C Foundation

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